which cbd oil is best for bladder cancer

Cannabis could be used to treat bladder cancer in dogs, Guelph researchers say

Sam Hocker hopes research will pave the way to a possible alternative to treat cancer in dogs

Guelph researchers hope to find out whether cannabis can be used as a possible treatment for bladder cancer in dogs as part of one of the first studies exploring the subject since legalization.

Over the next three years, Sam Hocker and a small team of researchers with the Ontario Veterinary College at the University of Guelph will look at what effects cannabidoil has on cancer cells, as well as the effects it can have on chemotherapy and radiation therapies in dogs.

"We really don't have a lot of evidence in dogs at this time to say, is this going to work? And in these different ideas of treatment in cancer or other aspects," Hocker said.

His research will look at whether potential anti-cancer properties of cannabidiol can kill cancer cells and if so, how.

Hocker said he chose to study cannabis as a potential treatment to bladder cancer in dogs because in his experience, the disease is "very frustrating" to treat.

He said bladder cancer is a very invasive disease in dogs and is also fairly resistant to most treatments. Hocker said veterinarians can't surgically remove the tumour like doctors can in human medicine.

"We don't have a lot of good therapies to provide long term outcomes for these patients," he said.

"From my stand point, if we're going to tackle a cancer, let's tackle one that's frustrating for us."

Increase to harm reduction

Kadri Uukkivi, co-owner Dunnville Veterinary Clinic (DVC), says the study is an important step in veterinary medicine and could open up more opportunities for alternative pet therapies and medicine in the near future.

"It's going to put us one step closer in getting products on the market that we can legally prescribe and recommend, which we can't do at this time," she said.

Most importantly, Carol Beauparlant, a technician at DVC and who is the clinic's cannabis counsellor, said the study would also help increase harm reduction among owners who already use cannabis products to treat other illnesses in their pets.

"We're providing harm reduction by talking about it," she said.

"We want them to be open about what they are doing and what they are choosing [to use] on their pets and we need to give them the right guidance on the safety of using it and how it could potentially benefit their pet."

Beauparlant adds there continues to be a stigma with cannabis use, even if it's used on pets, and urges owners to talk to their vets if they are using cannabis products on their pets.

CBD for Bladder Cancer in Dogs

Recently, the extent of research on cannabis’ effect on cancer cells is only growing, and new research showing the benefits continues to emerge. New research is just the start of what could be a groundbreaking connection between cannabis and cancer treatments⁴. Promising new research investigates the use of CBD for bladder cancer in dogs.

What is Bladder Cancer?

Cancer can affect all parts of the urinary tract, including kidneys, bladder, ureters, prostrate and urethra. However, bladder cancer is the most common diagnosis when dealing with cancer of the urinary tract in dogs. Although, when compared to tumors in other parts of the body, bladder cancer is still relatively uncommon, accounting for only 1-2 percent of all cancers in dogs.

Invasive transitional cell carcinoma (TCC) of intermediate to high grade is the most common bladder cancer in dogs. TCC is a cancerous tumor that invades the bladder wall’s deeper layers, including the bladder muscles. TCC in dogs can also spread to lymph nodes and other organs.

While bladder cancer can affect any breed of dog, it is more common in Scottish Terriers than in other breeds, suggesting that a hereditary predisposition may be a risk factor. It’s also most commonly diagnosed in middle-aged to senior female dogs. Although the precise cause of bladder cancer in dogs is uncertain, there appears to be a correlation between a genetic predisposition and environmental factors, such as pesticides and insecticides.

Symptoms of Bladder Cancer in Dogs

Early signs of bladder cancer include straining to urinate, painful urination, increased urination and incontinence, and blood in the urine. These symptoms increase in severity as the cancer progresses and can become life threatening if not closely monitored and staged³. In later stages of bladder cancer, some dogs experience lameness due to the cancer spreading to the dog’s bones or other organs. Definitive diagnosis is important, since things like a UTI (urinary tract infection) can mimic the early symptoms of bladder cancer, and obviously UTIs are less serious (yet still very important to address) than bladder cancer.

Common symptoms can include:

  • Frequent urination, in small amounts
  • Difficulty urinating
  • Loss of bladder control, More accidents in the house
  • Discoloration or blood in urine
  • Urinary tract infections, especially reoccurring or persistent UTIs

Generally speaking, bladder cancer is harder to diagnose early, and by the time symptoms develop, there is already disease progression. Using proactive measures to prevent this cancer, or any cancer for that measure, is important. Using full spectrum hemp extract as part of your dog’s nutrition protocol, which includes a balanced and fresh whole food diet, can help support the body as a whole and protect against many inflammatory issues, including cancer.

CBD for Bladder Cancer: New Research

In a promising study conducted in Canada², research was conducted to investigate CBD’s ability to treat canine urothelial carcinoma (bladder cancer). The study analyzed the difference in efficacy between the traditional standalone treatment, chemotherapy, versus chemotherapy and CBD together. The results showed that CBD for bladder cancer not only reduced cell viability and induced cell death in the canine urothelial cells on its own, but worked even better when combined with chemotherapy.

This study was done in vitro, which means it was done outside of a living organism. Further studies in vivo (within a living organism) are warranted, so that we can investigate how exactly this combination will be most successfully implemented in a clinical setting, and also to be able to transfer this into the human clinical setting. However, due to the nature of cannabis, in terms of its continued vilification by governments domestically and across the globe, researchers are limited in their scope. Until cannabis is de/rescheduled on the federal level, research cannot be done on living organisms (such as clinical trials on people). For now, as much preclinical work is being done as possible to create the foundation for clinical research when cannabis is descheduled federally.

The extent of the research being done on cannabis’ effect on cancer cells is only growing, and new research showing the benefits continues to emerge. As time goes on, and the demonization of cannabis lessens, more research is done proving cannabis (CBD, CBN, THC, and its other compounds) has a huge effect on cancer cells, and improving existing cancer treatments. We already know that CBD triggers apoptosis, stops metastasis, and has a positive effect when used with chemotherapy, but new research is constantly emerging regarding specific cancers and cannabis therapy.

References
  • ¹Hamad, Hussein, and Birgitte Brinkmann Olsen. “Cannabidiol Induces Cell Death in Human Lung Cancer Cells and Cancer Stem Cells.”MDPI , 17 November 2021
  • ²Inkol, Jodan M., et al. “Combination therapy with cannabidiol and chemotherapeutics in canine urothelial carcinoma cells.”PLOS , 5 August 2021
  • ³NC State Veterinary Hospital. “Canine Urothelial Carcinoma.”NC State College of Veterinary Medicine
  • ⁴Seltenrich, Nate. “Encouraging Cancer Research.”Project CBD , 1 January 2022
Krysta Fox

Krysta Fox is an experienced Veterinary Technician, a career inspired by her own beloved pug’s medical issues. With her years of experience working in traditional, holistic, and integrative practices, working alongside some of the most gifted practitioners in the industry, her varied experiences have played a key part in expanding her knowledge of veterinary medicine. She has also previously taken on several roles within the industry, including the manufacture and sales of raw pet food as well as consulting on animal health and nutrition. With her combined veterinary and pet industry knowledge, she can effectively help almost anyone she comes across in some way regarding their pets’ health.

Bladder Cancer & Cannabis

Medical cannabis is often recommended as a way to treat the side effects of cancer treatments, such as nausea, fatigue, and pain. However, there has been resistance and lack of research connecting the actual treatment of cancer to medical marijuana.

One of the reasons smoking cannabis has been resisted as a treatment is that ingesting anything into your lungs may damage it. However, studies indicate that ingesting cannabis may correlate with lower rates of one specific type of cancer.

Of all the cancers diagnosed in the United States each year, about 5% are cancers of the bladder. Unfortunately, it also claims over 16,000 lives annually.

The Urinary System & Bladder Cancer

The bladder is a part of the urinary system, which also includes the kidneys, renal pelvis, ureters, and urethra.

As blood flows through the body, it is filtered by the kidneys. The waste product created by the filtering process is urine, which is stored in the bladder until it can be expelled.

The bladder is a hollow, balloon-shaped organ in the lower part of the abdomen. It has a muscular wall that expands or contracts in order to store the urine produced by the kidneys.

Bladder cancer occurs when malignant cancer cells form in the tissue lining of the bladder. There are three types of bladder cancer: Transitional Cell Carcinoma, Low-Grade Transitional Cell Carcinoma, and High-Grade Transitional Cell Carcinoma.

The most significant risk factor involved in the appearance of bladder cancer is genetic history – as with many diseases – cigarette smoking dramatically increases the risk, as does aging. Tobacco smokers and non-smokers alike, however, have experienced lower rates of bladder cancer if they also ingest cannabis.

The Studies

In 2013, Dr. Anil Thomas and his team from the Kaiser Permanente Los Angeles Medical Center presented their findings regarding bladder cancer and cannabis use to the American Urological Association conference. The results of their work showed that individuals who used cannabis in some form were 45% less likely to be diagnosed with bladder cancer than patients who never used the substance. The medical professionals did not assert that marijuana smoking prevents bladder cancer. However, the research opened the door to ask the question about the efficacy of marijuana in treating disease. While there was a clear correlation, further research was required.

In 2017, Scientific Reports published a study that reported that the cannabinoid system played a role in bladder cancer becoming malignant. Results indicated that cannabinoids lessened the tumor’s growth.

Of course, natural homeopaths have long contended that cannabis can cleanse and detoxify the body, flushing out the harmful elements and protecting the good. Medical cannabis has also been proven to have positive effects when dealing with anxiety, inflammation, nausea, and a host of other ailments.

Although more research is still needed, studies are pointing to the fact that cannabis may also play a role in the actual treatment of cancer. As medical cannabis becomes more mainstream in the medical community, we expect to see more studies and research on this topic. If indeed cannabis is one day proven to reduce cancer risk, this will be a huge step forward in our understanding of how to effectively treat the disease.

If you are living with a disease or illness and would like to learn more about using medical cannabis as a possible treatment, call Neurology of Cannabis in Sarasota.

Click here to read more about the Florida list of qualifying conditions for medical cannabis.

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