what mg cbd oil is adequate for pain

What mg cbd oil is adequate for pain

The hemp plant contains cannabidiol, a natural compound with no psychoactive effects. Moreover, it is a compound from the hemp plant with many healing properties. It helps rid stress, pain, fatigue, depression, and anxiety. Unlike its counterpart, THC, it has little to no side effects. Thus, a perfect option for those looking to get the health benefits of CBD without getting high. Everyone would love to try CBD gummies but finding the best CBD gummies on the market is quite daunting. With so many businesses in the market, finding a good brand is difficult since they all claim to have the best product.

These bite-size gummies come in different colors and flavors to freshen your mood and improve everyday life. The dosage of these gummies is standardized, and they are easy to take. Take one from the bottle and pop it in your mouth. These gummies are safe to use and only contain little THC that brings a soothing effect to ease your mind. They are pre-dozed and deliver the same amount of CBD on every chew. You can eat one anytime you want, whether in a stressful meeting, in traffic, or if you wish to chill at home.

CBD gummies are getting a lot of attention after the CBD oil in the CBD industry due to their numerous advantages and ease of use. Due to that popularity, you will find hundreds of different brands selling this product. To make it easy for you, we researched and found the best CBD gummies that are safe to use and provide desirable effects.

The Top CBD Gummies On The Market

    : Overall CBD Gummies On The Market, Editor’s Choice: Most Potent Hemp Edibles Infused With CBD: Vegan CBD Gummies With Variety Of Flavors: Full Spectrum CBD Gummies In The Cannabis Market: Most Popular & Best Tasting Cannabis Gummies

#1. Exhale Wellness: Overall CBD Gummies On The Market, Editor’s Choice

Exhale Wellness is the top-rated CBD gummies brand in the market, committing to produce 100% natural hemp products. They do not use additives, and their gummies possess multiple health benefits like reducing stress, pain relief, and getting rid of anxiety. Their customers keep coming back for more since their gummies are as effective as they claim and can satisfy various needs.

One can be buying CBD gummies from their official website, which means no fake product and no chances of fraud. They also offer low and high potency levels in their gummies, making them suitable for newbies and old users. You can grab a pack of 30 or 60 gummies; a bottle will last a month if you use one gummy daily.


Low Price: Exhale Wellness CBD gummies are relatively cheaper than other brands. They also offer 25% off on your first purchase and monthly or weekly subscription for an extra discount. You can get a bottle at 50% off if you are a new customer and want to use their subscription service. It is an excellent choice for those on a tight budget.

High-Quality Gummies: This brand only opts for high-quality ingredients in their gummies to give their customers the best product. The hemp they use is organic, grown using organic farming practices that are environmentally friendly and sustainable. Their gummies are gluten-free, non-GMO, and vegan friendly.

Transparency: Exhale Wellness stays transparent by showing the ingredients they use in their product. They also publish the latest lab report with each product to ensure the customer’s safety and show proof regarding the quality of their products. Moreover, their customer support is always ready to answer your queries, a plus point for beginners to learn about the dosage and other guidelines.

Multiple Flavors In A Single Bottle: This is something you will not see in other brands. Instead of giving multiple flavors separately, Exhale Wellness provides different flavored gummies in a single bottle. An excellent option for those who are sharing a single bottle with others or who want to try different flavors before settling for one.

  • Free shipping available
  • 30-day money-back guarantee
  • Fast dispatch and delivery
  • Two potency levels are available
  • No international shipping
  • Shipping is restricted in some US states

#2. BudPop: Most Potent Hemp Edibles Infused With CBD

BudPop is the best brand for newcomers due to its moderate potencies, which will not cause undesirable effects. They also add ashwagandha to their gummies. Ashwagandha is a 3,000 years old herb famous for stress and anxiety relief. BudPop combines this herb with CBD to get the benefits of both worlds.

The result of this combination stimulates dopamine and serotonin production, which helps in reducing anxiety and stress. BudPop’s gummies are excellent for those trying to quit smoking but do not want to use a nicotine patch. Moreover, it helps manage withdrawal symptoms such as headaches and insomnia.


Different Types of Gummies: Apart from flavors, BudPop offers different gummies for unique results. For insomnia and restlessness, you can use CBD+CBN sleep gummies. They offer CBD+CBG turmeric gummies to target chronic pain and inflammation. CBD+Ashwagandha CBD gummies are the best option to rid of stress and anxiety. Moreover, they have full-spectrum gummies in watermelon flavor.

Available in Packs: You can save money by grabbing a pack of three or five bottles on the BudPop website. It is an ideal option if you are not the only one using the gummies or do not want to order every month. CBD gummies have a shelf life of 12 months, so even if you finish one bottle in two months, you can finish five bottles before their expiry date.

Contain 0.3% THC: THC gives you a high, but since it is only minimal in these gummies, it is non-intoxicating. These gummies provide the immense relaxation you want without losing focus. Following the 2018 Farm Bill, the regulated amount of THC should be less than 0.3%. Since the high feeling is not strong, you can use these gummies to give you that sweet buzzed feeling but keep your focus and concentration intact.

Extensive Dosing Directions: On the BudPop website, you can find the correct usage and dosing directions if you are unsure of where to start. They even offer you a quiz to check what dosage is proper for you. Visit their website, wait for a few moments, and you will see the quiz pop-up.

  • Candy-like taste
  • Gluten-free
  • Vegan and organic gummies
  • Non-GMO products
  • Third-party lab tested
  • Only accepts unused products for a full refund

#3. Cheef Botanicals: Vegan CBD Gummies With Variety Of Flavors

Cheef Botanicals has partnered with Colorado hemp farms to create clean, pure, and safe CBD gummies for consumers. Their founders have a combined experience of over 25-years in the food industry. Their deep knowledge about health and creating CBD products allowed them to fill the gap in the CBD industry.

The founders ensured that the products were free from pesticides, herbicides, solvents, and other chemicals. They have lab reports on their website to prove their products’ safety. The unique formulation in their gummies is suitable for everyone, including those with strict or special diets. Moreover, their gummies are free from animal gelatin and are cruelty-free.


Full-Spectrum CBD Gummies: This brand only offers full-spectrum CBD gummies, which means they contain traces of THC. The concentration is lower than 0.3% and provides a mellow high that helps you calm and relax. It also has other essential compounds from the hemp plant to bring multiple health benefits. It can help you destress while enhancing your health.

Various Sweet Fruit Flavors: Some companies rely on artificial sweeteners to make their products tasty. Cheef Botanicals only uses organic brown rice syrup and cane sugar to sweeten their products. They also add various fruit flavors in their gummies to give your taste buds a treat. Also, they refrain from adding food color, animal by-products, or corn syrup in their products.

Double-Dosage: You can use Cheef Botanicals gummies three times a day since they are not highly potent. The company recommends that you eat gummies based on your weight, and they have a guide for this on their website. Ideally, you can take 0.25 mg/lb for regular and 0.5 mg/lb for heavy dosage.

Third-Party Testing: Cheef Botanicals undergo independent lab testing to rule out impurities and confirm their CBD levels. They go through lab tests as soon as their new products arrive or refill the stock; thus, you will get the latest lab reports on their website.

  • Interesting line of topical flavored products
  • Strong, effective CBD products
  • Organic hemp from Colorado
  • Affordable prices
  • Offers subscription and bundle options
  • No assistance programs offered

#4. Hollyweed CBD: Full Spectrum CBD Gummies In The Cannabis Market

Hollyweed CBD is well known for its quality and dedication to serving its customers by providing them with the best CBD products. They even categorized their gummies in light and strong sections and advised their customers to start with the light dosage. The brand made its way to our list by consistently delivering high-quality CBD gummies. Their broad-spectrum CBD gummies are well-loved by their customers, making them stick to this brand for all their needs. Hollyweed CBD also has the best refund and buying policy and creates a transparent relationship between the buyers and sellers.


CO2 Extraction Method: Despite this method being expensive, Hollyweed CBD sticks to it since it is the safest method that brings out the best compounds from hemp. It also removes all the toxic components from the plant, making the product safe for consumers. Their lab reports prove that they use the CO2 extraction method to extract CBD and THC from the hemp plant.

Return Policies: If you do not like Hollyweed CBD gummies, you have a total of 45-days to return them. They give you extra 15-days in case you change your mind and decide to use the product instead of returning it. They also ship the product within 2-3 business days, so you have a lot of time to decide whether you want to use their products or not.

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No Additives or Preservatives: Their CBD gummies are free from any food coloring artificial sweeteners; they do not even use sugar in their product. The sweetness or tanginess comes from the natural fruits. They are available in cube shape, and you can fit as many in a small container. Moreover, they also add sunflower seed oil, organic vegetables, CBD oils, and spirulina to their gummies.

Three Potency Levels: Hollyweed CBD offers CBD gummies at 10 mg, 25 mg, and 50 mg potency in each gummy. You can start from the lowest dosage if you are new; you can gradually increase your dose or potency if you find the effects lacking.

  • Light CBD gummies available for beginners
  • High-quality vegan products
  • Less than 0.3% THC
  • A complete money-back guarantee
  • On-time Delivery
  • It is only available online

#5. FAB CBD: Most Popular & Best Tasting Cannabis Gummies

FAB CBD was founded in 2017, a Pennsylvania-based company manufacturing hemp products for the average user. The main motive of the brand is to create high-quality products for customers’ relief with the best customer service. FAB CBD spends its time and resources to carefully create its supplements so its customers can enjoy them to the fullest without worry.

Instead of relying on other companies, FAB CBD professionals supervise the whole process, including sourcing the hemp and other ingredients. Their CBD even works as a post-workout supplement to get rid of body fatigue and tiredness and help recover stamina quickly.


Interest-Free Installments: If you use Sezzle, you can purchase gummies from FAB CBD in four easy installments. You do not even need to visit Sezzle to do anything; this option is available right on the FAB CBD website. The installment approval is instant, and you can pay within six weeks. It is not restricted to one product; you can split your entire order into four installments.

Terpenes: To enhance the experience of their gummies, FAB CBD adds terpenes to their products. Their users find the addition of terpenes more beneficial than using isolated CBD gummies. These terpenes enhance the effects of CBD gummies; it helps reduce chronic pain, depression, anxiety, and even nicotine and opioid addiction.

Gummies for Day and Night: FAB CBD offers gummies based on time instead of categorizing them on flavors. If you want to stay active, grab the Anytime gummy pack, and if you want a good night’s sleep, the Nightime Blend is for you. They have 25 mg of potency in each gummy for the day to keep you active and 12.5 mg of the night to help you sleep smoothly.

Informative Blog: You can find a dedicated blog section on the FAB CBD website if you are interested in learning about hemp products. Every time they launch a new product or share informative posts, you can find all about it in their blog section.

  • Have gummies for day and night use
  • Contains healthy terpenes
  • Effective against post-workout fatigue
  • 30-day return and refund policy
  • Use natural flavors
  • Vegan-friendly and cruelty-free
  • Can only be bought online
  • Free shipping only applies for purchases $99 and above

How We Made This List Of Hemp Gummies & Cannabis Edibles

Before starting this guide, we made a list of many popular CBD gummies. We made a list of criteria that serve as a standard for these gummies. After thoroughly researching the brands, we removed those that fell short of expectations until only five brands were left.

  • CBD Dosage: People utilize CBD gummies for various reasons, and some prefer varying potencies. Some may be satisfied with 5 mg low-potency gummies. Others might want stronger potency ones that reach up to 50 mg. Those brands offering different potency levels were our priority. Moreover, the price of a product varies with potency, which is a plus point for the user.
  • Hemp and CBD Source: US hemp is one of the best in the world, and we only chose those products that source their hemp locally. Any brand using imported hemp did not make it to our list. Brands that did not disclose their hemp source were also crossed out. On the other hand, full-spectrum CBD was our priority since it contains all the beneficial compounds of the hemp plant.
  • Natural Flavors: Hemp’s pure, earthy taste is not suitable for all taste buds, so companies add flavors to their product to make it more bearable. The problem is that most artificial flavorings have chemical and synthetic substances. We avoided all this and only opted for brands that use natural flavors from fruits to make their gummies worth tasting.
  • Third-Party Lab Testing: Companies who want to earn the trust of their customers by delivering healthy products must prove that they are as good as they claim. The only way to do this is via lab tests. Third-party labs do these tests and are objective to ensure no manipulation with the results. Once a brand passes these tests, the lab will release a Certificate of Analysis (COA). Seeing a lab report on the brand’s website means transparency; the brand is not hiding anything and is confident in its products. Moreover, the brands we chose frequently updated their lab reports.
  • Brand’s Reputation: A dependable brand is what we all look for, a company that is not out to make a quick buck but instead provides high-quality hemp products. The only way to learn about a brand’s reputation is through customer reviews and background checks. The top brands we chose all have above 4.5-stars ratings. It means the CBD gummies they offer have satisfied their customers and are safe to use.

Buying Guide for Hemp Edibles

  • Type of CBD
  • CBD Potency
  • THC Potency
  • Price
  • Ingredients

What is inside a CBD product matters a lot; additives and preservatives can be a big problem if you want to use CBD products daily. So, do not just settle for a cheap or potent product, instead read the entire ingredients list before buying it.

The best CBD gummies are made from pure, organic, and simple ingredients. You might find food coloring in some brands since it is common in CBD products, but that will not reduce the potency or affect the flavor. You will still get to enjoy your gummies as you want. Also,, if you wish to enhance the effect of CBD in your system, then you can try them with the best testosterone booster as suggested by the top health experts.

Frequently Asked Questions On The Best Hemp Edibles On The Market

Q1. Which brand has the best CBD gummies?

There is no proper answer to that; every brand offers something unique. It depends on your taste, what effects you want, and the product’s potency. Exhale Wellness is on top of our list since it has the best CBD edibles overall. BudPop offers the highest potency levels if you want more potent gummies, but they do not ship outside the USA. FAB CBD has the widest variety of flavors; this might become your favorite brand if you try different flavors. If you are a vegan, Cheef Botanicals has vegan CBD-infused gummies that provide you with the same effects.

Q2. How to use CBD gummies for pain?

CBD affects the pain receptors in the body; it also offers anti-inflammation and analgesic effects. Eat the gummy like usual and wait for at least 20 minutes for the effects to kick in. If you want to engage in an activity like visiting someone or going to the office, you better take a gummy at least one hour before to get the optimum results. For high pain levels, you need to increase the dosage.

Q3. Are CBD gummies legal?

After 2018, all hemp-based products are legal in most states of the USA, though there are some restrictions. Only US-based hemp is allowed since it is the safest one. The THC concentration in products should not be more than 0.3%. Plus, the product must go through third-party lab testing to prove its safety. With all that said, CBD products are still illegal in some states, while some allow them strictly for medical use. Also, you might need to check your relevant authorities if you live outside the US.

Q4. How many CBD gummies should I eat?

If the dosage is correct, then only gummy would be enough. If you find that the effects are not enough, you will have to experiment a little to find out. You might need to cut it in half in case of a more potent dosage or take two if one CBD gummy does not provide satisfactory results. For a beginner, it is better to take one or two organic CBD gummies and wait at least an hour to find out the results. Getting a headache and a rumbling tummy means the doze is strong, and feeling no effect means the dose is low.

Q5. Can I overdose on CBD gummies?

It is impossible to overdose on CBD gummies since THC is very low on them. You might get some side effects like extreme fatigue, nausea, diarrhea, dry mouth, or vomiting. Since these effects will wear off when THC is out of your system, there is nothing to worry about. However, if any of these side effects become worse or still linger for more than a day, contact your doctor immediately. CBD does not have any significant side effects, but still, it is better to be safe and consult your doctor in case of such issues.

Q6. How long will you feel the effects of CBD gummies?

Most people take CBD gummies for sleep, and the effects stay for almost six hours. CBD gummies are gentle and do not cause any intoxicating or psychoactive effects, and they tend to work for a long time. Depending on your body, the effects may last up to six hours, and you might get on with it for eight hours or more. If you want to endure the whole day, you will have to take more than one gummy. Outside factors can also come into play; in the case of highly stressful environments and movement, the relaxing effect wears off quickly.

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Q7. Will CBD show on a drug test?

Cannabidiol (CBD) will not show on a drug test as long as you use THC-free CBD. Any product containing THC traces will be caught in a drug test, even if the concentration is low. It means, in rare cases, using a CBD product might lead to a failure in the drug test. If you plan to have a drug test, stay away from CBD for at least a couple of weeks to ensure that it is out of your system entirely.

Q8. Do CBD gummies stay in your system?

Yes, CBD gummies stay in your system for two to five days, but that does not apply to everyone. The CBD gummies will not remain in their system for more than two days if a person is active. It will take more time for a person who spends more time sitting on a chair or has a sedentary lifestyle. It is better to do light exercise if you use CBD gummies to get the best results.

Conclusion: Buy Weed Edibles & CBD Gummies

If you ever want to try a CBD product but worry about the adverse reactions, give these CBD gummies a try. They are easy to consume and available in the lowest possible dosage, free from psychoactive effects. Moreover, they are also more affordable compared to other CBD products.

We presented the best CBD gummies in the CBD market, each brand offering something unique. Now, you have an easy option to grab the best CBD gummies on the market and spend your day and night in peace.

If you want the best overall package, Exhale Wellness is the best brand. For saving money but getting a valuable product, Hollyweed CBD is the best. If you are unsure what to decide, any of these brands will provide you with the desirable results you want. Make sure to consult your doctor before using any of these products if you have pre-existing conditions or using medications as it can cause an undesired drug interaction.

The news and editorial staff of Sound Publishing, Inc. had no role in the preparation of this post. The views and opinions expressed in this sponsored post are those of the advertiser and do not reflect those of Sound Publishing, Inc.

Sound Publishing, Inc. does not accept liability for any loss or damages caused by the use of any products, nor do we endorse any products posted in our Marketplace.

CBD & CANNABIS DOSAGE GUIDE – Project CBD Interview with Dr. Sulak

It can be relatively easy to experience medical benefits from cannabis. A puff or two of tetrahydrocannabinol ( THC )-rich flower can do the trick for a lot of people.

Smoking marijuana, however, is not the be-all and end-all of cannabis therapeutics. There are many ways to experience the medical benefits of cannabis, and some of them are even non-intoxicating.

In recent years, the advent of potent cannabis oil concentrates, non-intoxicating cannabidiol ( CBD ) products, and innovative, smokeless delivery systems have transformed the therapeutic landscape and changed the national conversation about cannabis.

It’s no longer a question of whether marijuana has medical value. Now it’s about figuring out how to optimize your therapeutic use of cannabis to suit your lifestyle and situation.


Optimizing therapeutic cannabis use can be a challenge – for doctors as well as patients. Most physicians never learned about cannabis in medical school and, according to a 2017 survey, few feel they are qualified to counsel patients about dosage, CBD : THC ratios, different modes of administration, and potential side effects.

“Dosing cannabis is unlike any therapeutic agent to which I was exposed in my medical training,” says Dustin Sulak, D.O., the director of Integr8 Health, which serves patients at offices in Maine and Massachusetts. “Some patients effectively use tiny amounts of cannabis, while others use incredibly high doses. I’ve seen adult patients achieve therapeutic effects at 1 mg of total cannabinoids daily, while others consume over 2000mg daily without adverse effects.”

Cannabis comes in many different forms with a wide range of potencies, and its production and distribution have yet to be standardized in states where cannabis is legal for therapeutic use. So what’s the best way to proceed when it seems like cannabis dosage is all over the map?


“Most people are surprised to learn that the therapeutic effects of cannabis can be achieved at dosages lower than those required to produce euphoria or impairment,” says Dr. Sulak, who asserts that “ultra-low doses can be extremely effective, sometimes even more so than the other extreme.”

Preclinical science lends credence to the notion that a small amount of THC can confer health benefits. Oral administration of a low dose of THC (1 mg/day) resulted in significant inhibition of disease progression” in an animal model of heart atherosclerosis (hardening of the arteries), according to a 2005 report in Nature, which noted: “This effective dose is lower than the dose usually associated with psychotropic effects of THC.”

Because of federal cannabis prohibition and consequent research restrictions, clinical data is lacking to determine if low-dose THC therapy can protect against atherosclerosis in humans. But this much is certain: The practice of micro-dosing – which entails the consumption of a sub-psychoactive or slightly psychoactive dose of cannabis – is gaining popularity among those who want the medical benefits of cannabis without the buzz.

Although banned by federal law, cannabis medicine is currently accessible in the form of concentrated oil extracts, infused sublingual sprays, tinctures, edibles, gel caps, topical salves, and other products.


The successful use of cannabis as a medicine largely depends on managing its intoxicating properties. Many people enjoy the cannabis high; for others it’s unpleasant. A person’s sensitivity to THC, the main intoxicating component of cannabis, is key to implementing an effective treatment regimen.

“The practice of micro-dosing – which entails the consumption of a sub-psychoactive or slightly psychoactive dose of cannabis – is gaining popularity among those who want the medical benefits of cannabis without the buzz.”

Cannabidiol (CBD) does not cause an intoxicating high like THC. CBD can actually lessen or neutralize the THC high, depending on how much of each compound is present in a particular product. A greater ratio of CBD-to-THC means less of high. Today cannabis patients have the option of healing without feeling high.

Broadly speaking, there are three types of resin-rich cannabis and cannabis products:

  • Type 1 (THC-dominant) – High THC, low CBD (famously intoxicating cannabis varietals)
  • Type 2 (THC & CBD) – Mixed THC and CBD cultivars (intoxicating, but not as edgy as THC-dominant varietals)
  • Type 3 (CBD-dominant) – High CBD, low THC (non-euphoric marijuana or hemp)

There’s also a fourth type – those rare cannabis cultivars that prominently express a so-called minor cannabinoid (like CBG or THCV). But in terms of what’s currently available for patients, the THC: CBD ratio is paramount and must be considered when formulating dosage strategies.

So, what’s the appropriate dosage for each of the three main types of cannabis?


The adage “start low and go slow” is apropos for cannabis therapy, in general, and THC titration in particular, as discussed by Caroline MacCallum and Ethan Russo in a January 2018 article in the European Journal of Internal Medicine. The authors, who are both physicians, provide sensible guidelines for health professionals and patients regarding the judicious administration of (Type 1) THC-dominant medicinal preparations.

If a new patient is going to smoke or vape THC-rich cannabis, Russo and MacCallum suggest they start with a single inhalation and wait 15 minutes before inhaling again. The effects of inhaled cannabis usually can be felt within a few minutes, thereby providing quick relief of acute distress. If need be, one can inhale an additional puff every 15 to 30 minutes “until desired symptom control is achieved.”

As for oral administration, one should keep in mind that it can take 60 to 90 minutes before the effects of a single dose are felt.

MacCallum and Russo suggest a carefully titrated regimen for consumption of ingestible THC-rich cannabis products. They recommend that patients with little or no experience using cannabis should start by ingesting the equivalent of 1.25 to 2.5 mg of THC shortly before bedtime for two days. If there are no unwanted side effects, increase the bedtime dose of THC by another 1.25 to 2.5 mg for the next two days. Continue to increase the dose of THC by an additional 1.25 to 2.5 mg every other day until the desired effects are achieved.

If there are adverse side effects, reduce the dose of THC to the prior amount that was well tolerated.



For adequate symptom relief, some patients may need to ingest a cannabis preparation two or three times during daylight hours in addition to their night-time regimen. Cautious titration is urged: On days 1 and 2, start with one dose of the equivalent of 2.5 mg THC; on days 3 and 4, increase to 2.5 mg THC twice a day; and, if well tolerated, up the dose incrementally to a total of 15 mg THC (divided equally throughout the day).

“Doses exceeding 20-30 mg/day may increase adverse events or induce tolerance without improving efficacy,” MacCallum and Russo warn.

Adverse events mainly pertain to THC and are dose-dependent. Very high doses are more likely to cause unwanted side effects.

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For most medications, a higher dose will pack a stronger therapeutic punch. With cannabis, however, it’s not so simple. THC and other cannabis components have biphasic properties, meaning that low and high doses generate opposite effects. Small doses of cannabis tend to stimulate; large doses sedate.

In practical terms, this means that starting low and gradually upping the dose of cannabis will produce stronger effects at first. But, after a certain point, “dosage increases can result in weaker therapeutic effects,” according to Dr. Sulak, “and an increase in side effects.” It is important to note that everybody responds to THC differently and builds tolerance at different rates. Check-in with yourself often while consuming cannabis to gauge the effects and side effects.

There are some negative side effects that can result from over-consumption. Sulak observes that “symptoms of cannabis overdose closely mirror the symptoms one would expect cannabis to relieve at appropriate doses: nausea, vomiting, diarrhea, sweating, spasms, tremors, anxiety, panic attacks, paranoia, dis-coordination, and disturbed sleep. Extreme overdoses can lead to hallucinations and even acute psychosis.”

By introducing small amounts of THC into your system, and increasing the dosage slowly, you minimize the risk of negative side effects. The goal is to take a large enough dose of THC to achieve therapeutic effects and a small enough dose to minimize negative side effects.


CBD and THC are the power couple of cannabis therapeutics. Both compounds have remarkable medicinal attributes, and they work better in combination than as isolates. CBD can synergistically enhance THC’s anti-inflammatory and pain-killing properties while reducing unwanted side effects.

A 2010 report in the British Journal of Pharmacologyanalyzed the effects of THC and CBD alone and in combination in an animal model of colitis. This preclinical study concluded that “CBD increased some effects of an ineffective THC dose to the level of an effective one.”

This is one of the many gifts of CBD: It can magnify the medicinal impact of a small amount of THC so that one need not consume an intoxicating dose to experience THC’s therapeutic benefits.

A clinical study published in the Journal of Pain examined the efficacy of different dosage levels of Sativex, a cannabis-derived sublingual spray with a 1:1 CBD: THC ratio, which is an approved medication in two dozen countries (but not in the United States). Of 263 cancer patients who were not finding pain relief with opiates, the group that received 21 mg of Sativex each day experienced significant improvements in pain levels, more so than the group that received 52 mg Sativex daily. And those given even higher doses (83 mg daily) reduced their pain no better than a placebo, but they experienced more adverse effects.

Although many patients do well at the lowest effective dose, some benefit from a high-dose cannabis oil regimen. Often these patients engage in a regimen that includes a substantial amount of CBD as well as THC. By reducing THC’s intoxicating effects, CBD makes high potency cannabis oil treatment easier to manage. If high doses are necessary, steady titration over several weeks will help build a tolerance to THC’s tricky intoxicating effects.

Cannabis therapeutics is personalized medicine. There is no single CBD:THC ratio or dosage that’s optimal for everyone. As little as 2.5 mg of CBD combined with a small amount of THC can have a therapeutic effect. If necessary, much higher doses of good quality CBD-rich formulations are safe and well-tolerated.

For patients new to cannabis, it may be best to start with low doses of a CBD-rich remedy (with little THC) and increase the dosage (and, if necessary, the amount of THC) step-by-step. Take a few small doses over the course of the day, rather than one big dose.

But a low-THC product is not always the best treatment option. A more balanced combination of CBD and THC could have a greater impact than CBD or THC alone.

In essence, the goal is to administer consistent, measurable doses of a CBD-rich remedy with as much THC as a person is comfortable with. Experiment, observe the effects and adjust the amount of CBD and THC until one finds the sweet spot with the right combination of both compounds.


Microdosing cannabis is a feasible option for those who prefer not to leap over the intoxicating threshold. High-dose CBD therapy is another way of healing without the high.

As a general rule, Type 3 CBD-dominant cannabis (with little THC) won’t make a person feel stoned. Nor will a pure CBD isolate (with no THC). But CBD isolates lack critical aromatic terpenes and other cannabinoids, which interact synergistically to enhance CBD’s therapeutic benefits. Single-molecule cannabinoids are simply not as versatile or as efficacious as whole plant formulations.

Preclinical research indicates that full-spectrum CBD-rich cannabis oil is effective at much lower doses and has a wider therapeutic window than a CBD isolate. “The therapeutic synergy observed with plant extracts results in the requirement for a lower amount of active components, with consequent reduced adverse side effects,” a 2015 Israeli study concluded. In animal studies, CBD isolates require very high – and precise – doses to be effective. Problematic drug interactions are also more likely with a high-dose CBD isolate than with whole-plant cannabis.

Hemp-derived CBD isolates and distillates are already available via numerous internet storefronts. If you’re shopping for hemp-derived products online, there can be some quality issues to address before purchasing. Drug companies are also eyeing single-molecule CBD as a treatment for intractable epilepsy, psychosis, and other diseases.

In a 2012 clinical trial involving 39 schizophrenics at a German hospital, 800 mg of pure pharmaceutical-grade CBD proved to be as effective as standard pharmaceutical treatments without causing the harsh side effects typically associated with antipsychotic drugs. But a follow-up study at Yale University found little cognitive improvement in schizophrenics who were given a CBD isolate.


Bereft of the THC stigma (and its therapeutic moxy), single-molecule CBD recently became an FDA-approved pharmaceutical for pediatric seizure disorders. This is good news for families with epileptic children that have health insurance. Anyone without health insurance won’t be able to afford Epidiolex, a nearly pure CBD remedy developed by GW Pharmaceuticals as an anti-seizure medication.

Consider the dosage range utilized in clinical trials of epidiolex. Children with catastrophic seizure disorders were given up to 20 mg of epidiolex per kg of body weight. Such high doses caused interactions with other anticonvulsant medications, requiring adjustments of the latter to avoid a toxic overdose.

By comparison, Dr. Bonni Goldstein, author of Cannabis Revealed, typically starts with a much lower dose of full-spectrum CBD-rich oil (1 mg CBD/kg of body weight) for epileptic children – with the understanding that the dose may have to be lowered or raised depending on the initial response. If necessary, Goldstein will increase the dose of CBD by increments of 0.5 mg/kg until a threshold of 5 mg/kg of body weight is reached. And that amount also may need to be adjusted.

Kids and adults metabolize drugs differently. It may seem counterintuitive, but young children can tolerate high doses of cannabis oil concentrates, including THC-rich formulations, which might be daunting for an adult. Thus, it’s not a good idea to calculate the dosage for an adult based on what works for a child.

If 1 mg/kg of CBD is an appropriate starting dose for a child, and an adult weighs 15 times more than the child, one should not assume that the correct CBD starting dose for the grown-up is 15mg/kg of body weight. That could be way too high a dose. While CBD has no known adverse effects at any dose, an excessive amount of CBD may be less effective therapeutically than a moderate dose. Similarly, it’s not a good idea to devise a dosage regimen based on data from preclinical animal studies, which usually involve high doses of single-molecule cannabinoids. Human metabolism differs from mice and rats, and data from animal models doesn’t always translate to human experience.


For people as well as pets, cannabis dosage must be individually determined. Several factors come into play, including one’s overall health and endocannabinoid tone, which are influenced by diet, exercise, sleep patterns, day-to-day stress, and genetics. Cannabis is best used as part of a healthy lifestyle.

Here are some dosage variables to consider:

  • Cannabis experience. Has the patient used cannabis before? Or are they a stoner who already uses cannabis every day but isn’t getting the best results? A veteran user may need a higher dose than a new user. Or a chronic user might need a break from getting high to reboot his or her sensitivity to cannabis (see Dr. Dustin Sulak’s cannabis “sensitization protocol” on Healer.com).
  • Time of day. Optimizing one’s therapeutic use of cannabis may entail using products with different CBD: THC ratios at different times of the day – more CBD for daylight hours, more THC at night.
  • Preventive dosing. Prolonged low-dose therapy may be advantageous for managing chronic symptoms or to prevent disease recurrence. Preclinical studies indicate that cannabinoids have neuroprotective and cardioprotective properties that could limit the damage of a traumatic brain injury or a heart attack.
  • Cannabinoid acids. Raw, unheated cannabis contains CBD and THC in their “acid” form, CBDA and THCA, which are not intoxicating. Consumed orally over several months, cannabinoid acids can be effective in very small amounts, but precise dosing is difficult when juicing raw cannabis. Other delivery systems are becoming available for CBDA-rich and THCA-rich products.

Cannabis is a safe and forgiving medicine. Figuring out how to make the most of its health-enhancing properties may involve some trial and error. No worries! At least cannabis isn’t harmful like so many FDA-approved pharmaceuticals.

So if you’re new to cannabis medicine or if you’re seeking to improve your therapeutic routine, remember this advice from Dr. Sulak: “Start low, go slow, and don’t be afraid to go all the way!”