what does cbd oil do for alzheimer’s

CBD for Alzheimer’s: Treatment reduces plaque buildups in the brain that cause disease

AUGUSTA, Ga. — Cannabidiol, or CBD, continues to gain support as a remedy for everything from stress to bacterial infections. A new study reveals marijuana’s non-psychoactive ingredient may also be the key to stopping the triggers for Alzheimer’s disease. Researchers from the Medical College of Georgia at Augusta University say high doses of CBD restores the function of key proteins that clean up beta-amyloid plaque buildups in the brain. These clumps are one of the major causes of Alzheimer’s, the most common form of dementia.

Their study finds a two-week treatment course in mice boosted the proteins TREM2 and IL-33. Both contribute to the brain’s immune cells being able to clean out dead cells and other debris in the body. When plaques pile up in the brain, they start interfering with the communication between neurons and lead to brain cell death. Levels of both proteins decrease in patients with Alzheimer’s.

For the first time, investigators report that CBD treatments normalized the levels of these proteins. CBD also helped to improve cognitive function in mice with a form of early onset familial Alzheimer’s. Dr. Babak Baban, an immunologist and associate dean for research in the Dental College of Georgia, says CBD helped to reduce levels of IL-6. Researchers believe this particular immune protein has a link to high levels of inflammation in Alzheimer’s patients.

“Right now we have two classes of drugs to treat Alzheimer’s,” neurologist Dr. John Morgan explains in a university release. “But we have nothing that gets to the pathophysiology of the disease.”

Currently, one class of Alzheimer’s medications increases the levels of the neurotransmitter acetylcholine, which the disease also reduces. The other class targets NMDA receptors that handle communication between the neurons and are vital for memory functions.

Tremendous cognitive boosts due to CBD

In the case of IL-33, the study finds CBD helps the protein sound the alarm that there are “invaders” in the brain that need sweeping out. Researchers add that IL-33 expression is highest in the brain, which is why it’s so important for fighting beta-amyloid plaque accumulation. Dr. Baban says IL-33 helps to turn down inflammation tied to Alzheimer’s and restores immune balance.

For TREM2, CBD allowed this protein to combine with other proteins on the surface of cells to transmit signals which activate immune cells. In the brain, TREM2 helps to activate microglial cells. These cells are exclusive to the brain and help eliminate invading viruses and damaged neurons.

The results of the mice treatments show their levels of IL-33 and TREM2 increased by seven and ten times, respectively.

Along with higher protein levels, mice performed better in cognitive assessment tests. The animals were better able to differentiate between familiar items and new ones and also displayed improved movement as well.

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Study first author Dr. Hesam Khodadadi notes that people with Alzheimer’s may experience movement problems like stiffness or an impaired gait. In mice, the disease causes them to move in an endless circle. However, Khodadadi reports this disorder stopped after treatment with CBD.

Can CBD help prevent Alzheimer’s in its early stages?

The study worked with mice experiencing the late stages of early onset Alzheimer’s; giving the subjects high doses every other day for two weeks. Khodadadi says the next step will be to determine the best doses for patients and experiment with CBD treatments administered earlier in the disease’s progression.

Researchers are also exploring if they can administer these CBD doses using an inhaler, which would improve the delivery of CBD to the brain. Currently, researchers gave the mice CBD doses in their stomachs and allowed it to filter throughout the body from there.

Study authors are also hopeful CBD will have the same impact on other versions of Alzheimer’s. Familial Alzheimer’s is an inherited, genetic version of the disease that typically surfaces in a person’s 30s or 40s. About 10 to 15 percent of patients have early onset familial Alzheimer’s.

Dr. Baban says the team is already looking to establish CBD’s effectiveness on the more common forms or Alzheimer’s in clinical trials. In these cases, plaques and neurofibrillary tangles both contribute to brain cell death. The study author notes that beta-amyloid plaques usually start to form in the brain 15 to 20 years before dementia symptoms even appear.

Can CBD Oil Help In Easing Symptoms of Dementia?

With the legalization of medicinal cannabis in recent times, experts’ attention has been riveted to the study of how cannabis compounds can help in the treatment of certain diseases. One of these compounds is cannabidiol, which you can purchase from an authorized retail pharmacy in Gastonia, North Carolina.

Cannabidiol, also known as CBD, is currently being studied by scientists to see if it has any positive effects on dementia. While clinical trials continue as of the time of writing, authorities in the subject have already found possible benefits of CBD for patients with dementia, particularly Alzheimer’s Disease.

One positive effect of CBD, for example, is that it improves the brain’s ability to remove dead cells and prevent them from accumulating. Now, it is a fact that the brains of dementia patients suffer damage from protein clumps and nerve tangles that gather on top of healthy cells.

It is the immune system’s job to remove these dead cells from the brain, or else the brain unleashes an inflammatory response. This inflammatory response starves the healthy cells of oxygen, damaging them in the long run. In patients with AD, these protein clumps tend to congregate on parts that govern memory and cognitive processes.

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CBD, being an antioxidant, reduces inflammation and boosts the brain’s immune system to remove these dead cells. Furthermore, Australian scientists have found that CBD can also stimulate cell growth and regeneration in the brain during trials.

For now, studies continue into cannabidiol’s potential benefits for dementia. It is still within doctors’ discretion to provide treatment to recommend that the patient’s family buy CBD oil from a trusted neighborhood pharmacy.

If you’re looking for a pharmacy in North Carolina for your medicinal needs, don’t hesitate to call us or drop by at You 1st Pharmacy . Let us know how we can help you.

La Jolla scientists study cannabis components as treatments for Alzheimer’s disease and sports injury pain

Scientific studies by two La Jolla institutions are focusing on components of cannabis as treatments for ailments including Alzheimer’s disease and pain from sports injuries.

Salk Institute for Biological Studies

Decades of research on medical cannabis has focused on the compounds THC and CBD in clinical applications. But less is known about the therapeutic properties of cannabinol (CBN). But a new study by scientists at the Salk Institute for Biological Studies indicates that CBN can protect nerve cells from oxidative damage, a major pathway to cell death.

The findings, published online last month by the journal Free Radical Biology and Medicine, suggest CBN has the potential for treating age-related neurodegenerative diseases such as Alzheimer’s.

“We’ve found that cannabinol protects neurons from oxidative stress and cell death, two of the major contributors to Alzheimer’s,” said study senior author Pamela Maher, a research professor and head of Salk’s Cellular Neurobiology Laboratory. “This discovery could one day lead to the development of new therapeutics for treating this disease and
other neurodegenerative disorders, like Parkinson’s disease.”

CBN is a compound of the cannabis plant that is molecularly similar to tetrahydrocannabinol (THC), but unlike THC, it is not psychoactive. It’s also less heavily regulated by the U.S. Food and Drug Administration.

Previous research by Maher’s lab determined that CBN had neuroprotective properties, but it wasn’t clear how it worked. The new study explains the mechanism through which CBN protects brain cells from damage and death.

Maher’s team looked at the process of oxytosis, which is thought to occur in the aging brain. Growing evidence suggests that oxytosis may be a cause of Alzheimer’s disease. In the study, the scientists treated nerve cells with CBN and then introduced an agent to stimulate oxidative damage.

They further found that the CBN worked by protecting mitochondria, the cell’s powerhouses, within the neurons. In damaged cells, oxidation caused the mitochondria to curl up — a change that also has been seen in aging cells taken from the brains of people with Alzheimer’s. Treating cells with CBN prevented the mitochondria from curling up and kept them functioning well, according to the study.

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To confirm the interaction between CBN and mitochondria, researchers replicated the experiment in nerve cells that had the mitochondria removed. In those cells, CBN no longer demonstrated its protective effect.

“We were able to directly show that maintenance of mitochondrial function was specifically required for the protective
effects of the compound,” Maher said.

In another key finding, researchers reported that CBN did not activate cannabinoid receptors, which are required for cannabinoids (compounds found in cannabis) to produce a psychoactive response. Thus, CBN therapeutics would work without causing the person to become “high.”

“CBN is not a controlled substance like THC . and evidence has shown that CBN is safe in animals and humans. And because CBN works independently of cannabinoid receptors, CBN could also work in a wide variety of cells with ample therapeutic potential,” said first author Zhibin Liang, a postdoctoral fellow in the Maher lab.

As a next step, Maher’s team is working to see if it can reproduce its results in a preclinical mouse model.

UC San Diego

The National Football League has awarded $1 million to two medical research teams — including one at UC San Diego — to study the impact of the non-intoxicating cannabis component cannabidiol (CBD) on pain management and recovery from sports-related injuries.

UCSD and the University of Regina in Canada were selected from among 106 submissions for research proposals executed by the NFL-NFLPA Joint Pain Management Committee, with UCSD’s team assessing the therapeutic potential of
cannabis for “relief of post-competition soft-tissue injury pain in elite athletes.”

According to an NFL statement, athletes outside the NFL will use vaporized treatments following game-related injuries, with the outcomes monitored via phone apps. Participating athletes will receive treatments of either 4 percent THC, 12 percent CBD, a combination of CBD and THC, or a placebo, according to UCSD. The university said that while no conclusions can be drawn until the study is completed, investigators believe the THC and THC/CBD combinations will prove to be the superior treatments.

According to a UC San Diego Health statement, professional rugby players were chosen for the initial trial, which not only will evaluate pain relief and recovery but also any effects on physical function, sleep, cognition and mood.

“An innovation of this research is using a real-world model of the NFL’s competitive injury burden with a group of elite athletes who experience similar injuries,” said Thomas Marcotte, a professor of psychiatry at the UCSD School of Medicine. “It’s a first-of-its-kind randomized trial to examine the possible practical efficacy of cannabinoids on post-competition pain.” ◆