what do they mix with cannabis for cbd oil


The word cannabinoid refers to every chemical substance, regardless of structure or origin, that joins the cannabinoid receptors of the body and brain and that have similar effects to those produced by the Cannabis Sativa plant. 1 The three types of cannabinoids that people use are recreational, medicinal and synthetic.

Research has found that the cannabis plant produces between 80 and 100 cannabinoids and about 300 non-cannabinoid chemicals. 1 The two main cannabinoids are delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). The most commonly known of the two is delta-9-tetrahydrocannabinol (THC), which is the chemical that is responsible for the psychoactive effects of cannabis. 2

The main difference between the two cannabinoids is that THC has strong psychoactive effects, meaning it makes a person ‘high’, whereas CBD is thought to have an anti-psychoactive effect that controls or moderates the ‘high’ caused by the THC. CBD is also thought to reduce some of the other negative effects that people can experience from THC, such as anxiety. 3

Commonly used cannabinoids

  • Butane hash oil
  • Cannabidiol
  • Cannabis
  • Medicinal cannabis
  • Synthetic cannabinoids

Explore cannabinoids on the Drug Wheel

The endocannabinoid system

The endocannabinoid system is a unique communications system found in the brain and body that affects many important functions. 5 It is made up of natural molecules known as cannabinoids, and the pathways they interact with. Together, these parts work to regulate a number of activities, including mood, memory, sleep and appetite. 3

What do cannabinoids do?

Similar to opioids, cannabinoids produce their effects by interacting with specific receptors, located within different parts of the central nervous system. Simply put, cannabinoids regulate how cells communicate – how they send, receive, or process messages. 4

Types of cannabinoids

    – the dried leaves and flowers (buds) of the cannabis plant that are smoked in a joint or a bong. This is the most common form.
  • Hemp – the fibre of the cannabis plant, extracted from the stem and used to make rope, strong fabrics, fibreboard, and paper. including pharmaceutical cannabis products that are approved by an organisation such as the Therapeutic Goods Administration (TGA), including nabiximols (Sativex®) and synthetic cannabinoids such as Dronabinol®. 5
  • HU-210 – a synthetic analogue of THC, first synthesised in Israel in 1988 and considered to have a potency of at least 100 times that of THC. 5
  • UR-144 – similar effects to THC, though slightly less potent than THC. 6
  • JWH – a series of synthetic cannabinoids created in 1994 by Dr John W. Huffman for studies of the cannabinoid receptors. 7
  • 5F-ADB – a synthetic cannabinoid that was first identified in late 2014 from post-mortem samples taken from an individual who had died after using a product containing this substance. 8
  • CUMYL-PEGACLONE emerged in late 2016 on the German drug market. 9 Anecdotal reports suggest that there are a number of adverse effects associated with CUML-PEGACLONE.

How are they used?

Illicit and synthetic cannabinoids are usually smoked, vaporised or eaten. Pharmaceutical or medicinal cannabinoids come in a variety of products including raw (botanical) cannabis which may be vaporised for medicinal purposes, as well as oils, liquids and oral sprays. Gels have also been developed for direct application to the skin. 5

Effects of cannabinoids

The effects of cannabis may be felt immediately if smoked or vaporised, or within an hour or two if eaten. General effects may include:

  • euphoria
  • feelings of well being
  • spontaneous laughter and excitement
  • increased appetite
  • dry mouth
  • quiet and reflective mood. 10

What are synthetic cannabinoids?

Over the years a number of synthetic cannabinoid products have been produced. They are similar to those of natural cannabis, yet, these drugs can be more potent and have been associated with a number of adverse effects.

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Synthetic cannabinoids are molecules designed to mimic the effects of THC. Like THC, these synthetic cannabinoids target the cannabinoid type 1 receptor (CB1R) in the brain, which is responsible for the psychoactive effects of THC in cannabis. 11

Many of these substances have developed to the extent that they no longer fit with the traditional cannabinoid classification system.

Cannabinoids and other drugs

The effects of mixing cannabis with other drugs, including alcohol, prescription medications and over-the-counter medicines, are often unpredictable.

Using alcohol and cannabis at the same time can increase the unpleasant effects, including nausea, vomiting and feelings of panic, anxiety and paranoia.

Some people use cannabinoids to ‘come down’ from stimulants such as amphetamines and ecstasy. The mixing of cannabis and ecstasy has been linked to reduced motivation, impaired memory and mental health problems. 12,13

Health and safety

Use of cannabinoids is likely to be more dangerous when:

  • taken in combination with alcohol or other drugs, particularly stimulants such as crystal methamphetamine (‘ice’) or ecstasy
  • driving or operating heavy machinery
  • judgement or motor coordination is required
  • alone (in case medical assistance is required)
  • the person has a mental health problem
  • the person has an existing heart problem. 14

There is no safe level of drug use. Use of any drug always carries some risk. It’s important to be careful when taking any type of drug.

Dependence and tolerance

Regular cannabinoid use, particularly when started in adolescence, is associated with dependence and lasting cognitive impairment (e.g. lower IQ), poor educational outcome, diminished life satisfaction and achievement, and an increased risk of psychotic disorders. 15


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  1. Fundacion Canna (n.d.) What are cannabinoids? Where can cannabinoids be found?
  2. Victorian Law Reform Commission (2015). Medicinal Cannabis. Retrieved from the Victorian Law Reform Commission.
  3. Cannabis Information and Support. (2017) Weeding out the differences between THC vs CBD.
  4. National Institute on Drug Abuse. (2012) How THC affects the brain.
  5. Therapeutic Goods Administration. (2018). Medicinal cannabis products: Patient information.
  6. United Nations Office of Drug Control. (2018). UNODOC Laboratory & Scientific Section Portals. Synthetic cannabinoids
  7. World Health Organisation. Expert Committee on Drug Dependence (2014). UR-144 Critical-Review Report.
  8. A Train Education. (n.d.) Synthetic Cannabinoids (Spice, K2).
  9. Mogler et al. (2017). Phase metabolism of the recently emerged synthetic cannabinoid CUMYL-PEGACLONE and detection in human urine samples. Drug Testing Analysis: Germany
  10. Brands, B. Sproule, B. & Marshman, J. (Eds.). (1998). Drugs & drug abuse (3rd ed.). Ontario: Addiction Research Foundation.
  11. NSW Parliament. (2000) Report of the Working Party on the Use of Cannabis for Medical Purposes. Sydney: NSW Parliament.
  12. Banister, S., McGregor, I. & Gerona, R. (2015). Labs make new, dangerous synthetic cannabinoid drugs faster than we can ban them.
  13. Klugman, A. & Gruzelier, J. (2003). Chronic cognitive impairment in users of ‘ecstasy’ and cannabis.
  14. KFx Drugs Consultancy (n.d.) Drug facts: Synthetic cannabinoids.
  15. Panlilio, L., Goldberg, S. & Zuzana, J. (2015), Cannabinoid abuse and addiction: Clinical and preclinical findings.

Last updated: 10 Nov 2021

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What Happens When You Mix Cannabis And Kratom?

It’s no secret that people are as likely to kick back on a lazy Sunday afternoon with a joint in hand as they are to reach for a cold beer. Just about half the US population from age 17 and up reported using marijuana during their lifetime in a 2019 survey. However, for some, it’s a simple and natural pain relief method, with none of the serious side effects of prescription drugs.

There’s been a new player in town in recent years, though – the Southeast Asian herb called Kratom. It’s a nifty little supplement that promises to reduce pain and elevate the mood, among other things. Naturally, many die-hard weed aficionados got wind of this, and a growing number of them are now interested in combining the two to get the best of both worlds.

However, before you experiment, we need to go over some of the basics.

You Can’t Just Jump in and Use Random Doses!

Weed is readily available worldwide, and it’s easy enough to find Kratom for sale on various sites, but we have to advise against going into this blind and winging it.

While these are both naturally occurring herbs, don’t fall for the naturalistic logical fallacy of believing that if it came from the ground, you could just put it in your body all willy-nilly without any consequences. There’s a right way to go about things, and a lot you need to know before trying to combine cannabis and Kratom.

How Does Cannabis Affect the Body?

We all know that familiar marijuana buzz, but let’s just go over the basics real quick, so we can get a better idea of how these effects will stack with Kratom use.

  • Feeling of euphoria
  • Decreased stress
  • Pain relief

And some of the potential side effects include:

  • Dry mouth
  • Feeling anxious
  • Nausea
  • Bloodshot eyes
  • Hunger and random food cravings
  • Forgetfulness
  • Slower reaction time

When people take larger doses of marijuana, a more potent variety, or are new to it, they might experience some adverse side effects. Now, let’s move on to Kratom, where you’ll see a degree of overlap, as well as some unique effects that may complement those of marijuana.

How Does Kratom Affect the Body?

Kratom is fascinating in that the effects are dose-dependent. Taken in lower doses, below 5 grams, it leads to:

  • Improved situational awareness and focus;
  • Feeling perky and animated;
  • Becoming chattier and friendlier;
  • Feeling a sex drive;
  • Loss of appetite;

However, in higher doses, from 5 to 15 grams, it begins to act similarly to an opiate, but with much milder side-effects:

  • Pain relief;
  • Feeling of serenity;
  • Slower reaction times;
  • Sleepiness;
  • Calming down coughing;
  • Reducing symptoms of withdrawal in opioid addicts;

The potential negative side-effects involve:

  • Redness in the face and constricted pupils;
  • Itchiness and increased sweating;
  • Lightheadedness and nausea;
  • Deteriorated motor skills and shaking;
  • Stomach ache and constipation;

As you can see, it’s vital to get the dose right if you want the desired effects. Low doses kick in fast, and the effects last about an hour, while higher doses take a bit more time to kick in but last for a few hours.

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What Happens When You Combine Them?

Because there are several different types of Kratom, and God knows how many strains of marijuana, you’ll have to look closely and the effects of the specific strain you choose. You can then mix and match the appropriate MJ strain, and you can play around with the dose. There is another option of getting benefits of cannabis without smoking it by using CBD oil capsules instead. However, there are generally four basic combos for specific outcomes:

  1. Small dose Kratom + high energy marijuana strain = maximum alertness and energy;
  2. Higher dose Kratom + downer marijuana strain = blissful contemplation, sleepiness, and pain relief;
  3. Small dose Kratom + downer marijuana strain = a short relaxing high, followed by an alertness kick;
  4. Higher dose Kratom + high energy marijuana strain = a nice bit of focus giving way to calmness;

You can go all out with upper effects, full downer effects, or time your ups and downs, using one herb to lull you in and another as an “Inception” style kick to wake you up from your dream-like stupor.

Proper Timing and Food are Essential

Kratom leaves are traditionally either chewed or brewed into a tea, but we now have it in pill form as a supplement. Either way, it needs to get digested first, and any food you eat a couple of hours before taking it can limit its effects. On the plus side, a full stomach will help rein in the effects, so when the weed kicks in, you won’t go overboard and risk getting nauseous.

It’s generally best to smoke a joint first, wait 30-60 minutes, then take Kratom, and have a snack shortly afterward.

To Recap

Yes, weed and Kratom can go well together, as long as you choose your strains carefully for the desired effect and time things right. Always start slow, with low doses, and take notes, so you can determine which combo gives you the best results.

Written By: Tammy Taylor


Total of 6 gs of white Marengo da, broken into 3 dose between 7am and 5pm, then at 6pm took 125mg of delta 8. Holy shite I’m on cloud nine like small dose mdma. It’s all about perfectly balancing the kratom over time!

I just heard someone else say it but I think repetition may be important:: I an pretty sure you are only supposed to take one THC gummy at a time.
I also read in this informative post we should: Take. It. Slow. 3 gummies + mixing Kratim the 1st time?! Seems unwise.
I an interested in this topic and appreciate everyone’s honest share, I am not trying to dis anyone. Actually I’m grateful b/c it helps me to move forward responsibly when I hear what not to do. So, thanks for sharing and for the article. I wish yo learn about the different kinds of kratum?

Well, I had 3 50mg delta 8 lifesaver gummies and 2 capsules about 2gms.and iam just very chill. I could do some marijuana thc but I don’t think I need to. It’s only been about 2 hours…I’ll wait for the effects to increase. But iam very glad IDO NOTt feel like I need to go to the hospital!.

I mixed keratom tea and smoke MJ and got really sick. I thought I needed to be in emergency room since my head start turinng and nausea and all that. just be careful like this article say.