types of cbd oil for seizures

CBD Oil for Seizures & Epilepsy: How Cannabis Oil Can Stop Seizures

According to the Michigan Epilepsy Foundation, 1% of Americans suffer from some form of epilepsy — a recurring neurological disorder known for frequent, often unprovoked seizures.

Epilepsy compromises all aspects of a person’s daily life. The violent tremors caused by a seizure attack can put the individual in grave danger, not to mention that people with epilepsy are also prone to suffer from sleep issues, migraines, anxiety disorders, and depression.

Of all epilepsy forms, up to 40% is drug-resistant, meaning the patient doesn’t react to Antiepileptic Drugs (AEDs). For these patients, AEDs are simply ineffective, or the side-effects are too severe to allow for continuous treatment.

As a result, many turn to natural resources to help manage their condition. CBD oil is one promising option whose antiepileptic effects have been thoroughly studied by scientists.

In this article, I’ll cover the potential benefits of CBD oil for epilepsy and seizures — and share the top brands I trust when it comes to manufacturing high-quality CBD oil.

Best CBD Oil Brands for Epilepsy & Seizures

There are lots of different CBD companies trying to make their name in the market with their CBD oil. Some brands provide high-quality products and can back up their claims with third-party lab reports. In contrast, others tend to take advantage of unaware consumers with lots of fancy buzzwords and unrealistic promises.

If you want a clean and potent CBD oil, you need to find a manufacturer that makes organic products with proper quality assurance.

Don’t have time for that? Don’t worry — I did the research for you.

Here are my top 3 brands that make premium CBD oil for different types of consumers.

1. Royal CBD

Get 15% off all Royal CBD products. Use code “CFAH” at checkout.


  • Royal CBD comes from organic hemp grown on American farms
  • The company employs CO2 extraction so their extracts are clean and safe
  • Their CBD oil comes in three different strengths: 250 mg, 500 mg, 1000 mg, and 2500 mg
  • Up to 83.3 mg of CBD per mL
  • Hemp extract is suspended in premium MCT oil
  • Every batch of product has been tested by a third-party laboratory


  • No vapes or vape oils available (yet)
  • The price is on the higher end, although justified

My Thoughts on Royal CBD:

Royal CBD is a premium brand that uses only high-quality ingredients in their product lineup. The company’s product range includes every basic CBD format, from sublingual drops to gummies and capsules.

The oil and capsules are full-spectrum, meaning they also contain other cannabinoids and terpenes from hemp. Gummies, on the other hand, contain 99% pure isolate.

The Royal CBD oil comes in three different potencies: 250 mg, 500 mg, 1000 mg, and 2500 mg. The strongest option gives you 83 mg of CBD/mL. I would recommend this variant for stronger symptoms. Those who need noticeably higher doses of CBD may find the weaker bottles cost-prohibitive.

If you don’t want to measure out the oil each time you need CBD, you may switch to Royal capsules. Each softgel carries 25mg of full-spectrum cannabidiol in an easy-to-swallow form.

All Royal CBD products are sent to third-party laboratories for content analysis — checking the potency of CBD as well as purity levels.

2. Gold Bee (Best Organic)


  • Unique product selection
  • Non-GMO, Colorado grown hemp
  • Full-spectrum CBD
  • Extracted with CO2
  • Up tp to 1200 mg of CBD per bottle (40 mg/mL)
  • Sweetened with organic honey
  • Third-party lab tested for potency and purity


  • No high-strength oils
  • Not available in-store
My Thoughts On Gold Bee:

Gold Bee specializes in all-organic CBD products, including full-spectrum CBD oil, high-potency CBD capsules, gummies, and delicious honey sticks. The company’s CBD oil is available in one potency option, packing 1200 mg of CBD per bottle.

This concentration translates into 40 mg of CBD in each milliliter. The oil has been suspended in premium-grade MCT oil and infused with natural terpenes to enhance the synergy between CBD and other compounds in hemp. There are two flavors available: natural and kiwi. The kiwi flavor is sweetened with organic honey, which only adds to the product’s value.

I’ve been taking the Gold Bee CBD oil for 30 days, using the dosage based on the recommended serving size. At first I was skeptical because I got used to higher doses in my routine — low doses could hardly calm my nervous system.

To my surprise, 1 mL a day split into two doses was enough to boost my resistance to stress and the outside stimuli. After two weeks, I slightly decreased the dosage and was still getting pretty good results. This was the first time a potency lower 1500 mg lasted more than 1 month for me.

3. CBDPure


  • CBDPure products come from organic hemp grown in Colorado
  • The company uses CO2 extraction
  • All products are tested by 3rd-party laboratories for potency and purity
  • Available in 60 mL bottles
  • 100% Satisfaction Guaranteed program — you can send your order back within 90 days for a full refund


  • CBDPure only sells CBD oil and capsules
  • The oil is slightly less potent than Royal CBD

My Thoughts on CBDPure:

CBDPure was established in 2016 by a group of cannabis advocates from Colorado. The company has a simple mission, which is to make premium-quality CBD oils from organic hemp.

Although CBDPure has a very narrow product range — offering only CBD oil and capsules — they seem to have perfected these products. All extracts from CBDPure are obtained using supercritical CO2 and tested in a certified laboratory for quality assurance.

The oil isn’t as potent as the one offered by Royal CBD, but if you benefit from lower doses, their 60-mL bottles will get you supplied for months to come. Their oils are a good option for people who use CBD for general health care or to ease mild symptoms.

If you’re looking for something potent, try CBDPure capsules — each softgel is infused with 25 mg of full-spectrum CBD for easier dosing and extra convenience.

CBDPure has a Satisfaction Guarantee program, so in case you ended up unsatisfied with your purchase, you can get a full refund if you send the order back within 90 days.

4. CBDistillery


  • CBDistillery uses Colorado-grown hemp
  • Their products are available as full-spectrum or isolate
  • They have an impressive product selection
  • Each batch is sent to a 3rd-party lab for content analysis
  • Very affordable


  • Their hemp isn’t organic

My Thoughts on CBDistillery:

CBDistillery is a company founded in Denver, Colorado. They’ve been offering high-quality CBD oil products for over 5 years now. One of the driving forces behind the brand is to manufacture CBD oil for every budget and promote research and education among consumers all over the country.

CBDistillery has many different forms of CBD, from sublingual tinctures to capsules, gummies, topicals, and vapes. Their CBD oil is available as ‘full-spectrum’ or isolate.

These oils come in two different sizes — 15 mL and 30 mL

The potency of the 15 mL bottle ranges between 150–1,000 mg of CBD. The 30 mL bottle offers from 2,500–5,000 of total CBD.

With such a wide potency range, CBDistillery oils may suit both novice and experienced consumers alike. The only downside to the company’s product range is that they’re not made with organic hemp.

However, this becomes understandable once you consider the price of CBDistillery products. The company may not sell the best CBD oil on the market, but they offer the best CBD products in this price range.

What is CBD Oil?

CBD oil is a cannabis extract with high concentrations of CBD. This product can be sourced from both marijuana and hemp, two members of the cannabis plant family.

It’s worth noting that marijuana-derived CBD oil contains higher levels of THC, the psychoactive cannabinoid responsible for getting users “high.”

CBD oil from hemp has only trace amounts of THC — typically below 0.3% — and thus can’t produce any psychoactive effects.

That’s because CBD is non-psychoactive per se.

CBD oil reportedly has a plethora of health benefits. However, the best-documented evidence thus far comes from epilepsy trials.

Does CBD Oil Work for Seizures?

The earliest studies proving the effectiveness of cannabis compounds in the treatment of convulsions came from animal research from the 1970s. The researchers analyzed the anticonvulsant properties of both THC and CBD oils, concluding that both extracts had substantial effects on mice.

Early experiments reported that the seizure activity might in part, be regulated by the endocannabinoid system — an interconnected network of cannabinoid receptors and neurotransmitters called endocannabinoids.

The Mechanism Behind the Antiepileptic Effects of CBD

The endocannabinoid system works to keep the body in a state of equilibrium, maintaining chemical balance and controlling biological functioning, from appetite to motor control, sensory perception, sleep, and inflammation.

It sends signals to various bodily systems through its chemical messengers called endocannabinoids to do this. These molecules bind to the cannabinoid receptors which occur in the brain and throughout the body. By doing so, endocannabinoids help the endocannabinoid system to maintain healthy functioning of an individual.

Once endocannabinoids have done their work, they get broken down by enzymes to prevent overaccumulation.

As a cannabinoid, CBD is almost identical in its chemical structure as endocannabinoids produced by your body. When you ingest CBD, it’s able to affect cannabinoid receptors on top of acting on several other pathways.

While scientists still don’t know exactly how CBD oil works for seizures, they’ve observed the following interactions which may explain the positive effects:

  1. Endocannabinoids are neuroprotectants, lowering the risk of seizures caused by neurotoxicity. When a person ingests CBD, they introduce more cannabinoids to their system—potentially improving the performance of the endocannabinoid system with their neuroprotective properties.
  2. The endocannabinoid system also modulates neuroexcitation, a process that may trigger seizures. A properly functioning endocannabinoid system, bolstered by additional cannabinoids from CBD oil, may prevent the overexcitation of neurons.
  3. CBD is also an anti-inflammatory agent. Seizures may be triggered, or their frequency may be increased by brain inflammation. By curbing neuroinflammation, CBD may reduce both the severity and frequency of seizure attacks.

Now, let’s elaborate on the scientific findings regarding the antiepileptic properties of CBD oil.

What the Research Says

The majority of specific case studies from the late 1990s, and the early 2000s focused on the effect of THC/CBD solutions on epilepsy. Due to the psychoactive nature of THC, the eyes of modern medicine turned to CBD.

In June 2018, the FDA approved the first CBD-based drug. The oral spray, called Epidiolex, contains 99% pure CBD. It’s used for treatment-resistant forms of childhood epilepsy — such as Lennox-Gastaut syndrome and Dravet syndrome.

Both diseases begin during early childhood and often lead to delayed or poor development of the child’s motor skills, language, intellectual aptitude, and the ability to communicate with others.

Before receiving the FDA’s approval, Epidiolex went through three randomized, double-blind, placebo-controlled clinical trials examining 516 patients with either syndrome. When administered along with other medications, Epidiolex successfully reduced the participant’s frequency of seizures compared to the placebo group. Besides, CBD improved other associated symptoms for the participants, such as sleep and anxiety.

Currently, Epidiolex can be officially used to treat these two types of epilepsy. However, recent research suggests that CBD may help relieve other forms of this disease as well.

For instance, a 2015 study analyzing the reports from Epidiolex patients from 11 epilepsy centers across the country showed that the frequency of seizures decreased by 36.5% after a 13-week treatment.

All subjects had severe, childhood-onset forms of epilepsy, including Lennox-Gastaut syndrome and Dravet Syndrome. The researchers started with a dose of 2–5 mg/kg per day and gradually increased it to 25–50 mg/kg per day.

Can You Develop a Tolerance to CBD Oil for Seizures?

People who have treatment-resistant epilepsy tend to experience a “honeymoon” period upon switching to a new therapy. In other words, they stop feeling the effects of their new treatment after a few months. In late 2018, scientists observed that the same pattern might apply to CBD treatment.

The study examined nearly 100 patients, of which about one-third developed a tolerance to CBD. The tolerance showed up about seven months after they began the therapy. From then on, they had to increase the dose to maintain the effects. When the dose was higher, nearly half of the examined sample experienced their previous response level.

The good news, though, is that for two-thirds of participants, the CBD proved effective in the long run.

How to Use CBD Oil for Epilepsy

CBD can take many forms. Epidiolex, the only approved CBD treatment for epilepsy, is an oral solution containing 99% pure CBD.

If you want to use CBD in a more natural form to see how it works for your symptoms, you may try the following formats:

  • Sublingual drops: The most common form of CBD. The drops are administered via a dropper under the tongue, where they get absorbed through special membranes into the bloodstream. Sublingual drops provide the most consistent blood absorption rates according to studies.
  • Capsules: CBD capsules are sold as pills and softgels. You just swallow them like any other pill. They offer a fixed dose of CBD in each serving, which makes dosing easier than sublingual drops, not to mention you can avoid any natural hemp taste.
  • Vape oils: this form of CBD is inhaled through a vaporizer or vape pen. Many people prefer vape oils over other products because they find the act of inhalation relaxing, and they like the flavoring of vape oils. But most importantly, vape oils deliver more CBD to your system than any other consumption method.

CBD Oil Dosage for Epilepsy & Seizures

The dose-finding process will vary between patients. As with every new substance, a conservative approach and slow dosage increase will minimize the chance of severe side effects and leave room for adjusting the dose from the starting point.

For each individual, the optimal CBD dosage will depend on the following:

  • CBD concentration
  • Cannabinoid spectrum
  • Route of administration
  • Weight
  • Age
  • Metabolism
  • Lifestyle choices
  • Medications the patient is already taking

Dr. Karen Keough, Chief Medical Officer at Compassionate Cultivation, created general dosage guidelines for dosing CBD oil to both adults and children who have epilepsy.

Dosing Recommendations for Children

Depending on the severity of symptoms, children may go through low-dose initiation and high-dose initiation.

Low-Dose Initiation instructions:

  • Start with 0.25 mg/lb/day
  • The minimum dose is 10 mg
  • Target dose ranges between 1–5 mg/lb/day. Higher doses are tolerated but at the cost of some mild side effects, such as dry mouth, dry eyes, low blood pressure, sedation, and dizziness.
  • Average dose is 1–3 mg/lb/day
  • Increase the dose every 1–2 weeks by 0.5 mg/lb/day, topping to the nearest 10 mg as long as there are no side effects.

High-Dose Initiation in Children:

  • Start with 0.5mg/lbs/day
  • Target dose ranges between 1–5 mg/lb/day
  • Average dose is 1-3 mg/lb/day
  • Increase the dose every 1–2 weeks by 0.5 mg/lb/day and monitor the effects
  • If side-effects occur, leave more time between dose increases and go up more gradually

Dosing Recommendations for Adults

Considering the factors above, such as body weight and metabolism, adults with epilepsy need more CBD in their regime than children. Use the following guidelines to reach an effective dose:

Low CBD dose in adults:

  • Start with 25 mg twice daily
  • Go up by 25 mg per dose every 1–2 weeks
  • Target dose ranges between 100–300 mg twice a day if no side effects are observed. Clinical trials have utilized doses as high as 1,500 mg of CBD daily, but such high doses might not be necessary to achieve seizure relief in most patients

High CBD dose in adults:

  • Start with 50 mg twice daily
  • Go up every 1–2 weeks by 50 mg/dose
  • Target dose ranges between 200–500 mg twice a day if tolerated. You may stop sooner if seizures are gone to prevent further dosage increase and possible side effects.

Where to Find CBD Oil for Sale for Epilepsy & Seizures

CBD oil is available both in cannabis dispensaries and online retail stores. Dispensaries give you access to a wide range of cannabis products, including CBD oil from hemp. However, these places may not always carry the best products, and the bottles have probably spent some time on the shelves before being sold so that they may lose potency over time due to poor storage.

That’s why I buy my CBD oil online. The majority of CBD stuff is sold this way, so you have more options to choose from. Also, you can verify the reputation of your potential vendor with the help of online research. Read user reviews, check for third-party lab reports, and learn how your company sources its CBD to make sure you’re getting a clean and potent product.

The delivery time for CBD oil is usually 2–3 business days. But in my opinion, it’s worth it to wait a few days more to get a high-quality product for a good price — CBD oil ordered online is usually less expensive than what you see in a dispensary.

Using CBD Oil for Seizures: Will It Help?

Cannabinoids have many proven beneficial effects on health, particularly in the treatment and management of epileptic seizures. Epilepsy is currently the only FDA-approved condition for treatment with CBD — although this approval doesn’t apply to hemp-derived CBD oil.

Still, if you want to try CBD oil for better management of your symptoms, I hope this guide has helped you understand how to use it to get the most out of its benefits. Just remember to start low and slow with the dosage.

But above all, consult with your doctor before purchasing any CBD product — just to make sure it won’t negatively interfere with any medications you’re taking.

Do you know any examples of people who successfully reduced the frequency of their seizures with CBD oil? Share your stories in the comments below!


  1. Filloux, F. M. (2016). Cannabinoids for Pediatric Epilepsy? Up in Smoke or Real Science? Translational Pediatrics, 4(4), 271–282.
  2. Perucca, E. (2017). Cannabinoids in the Treatment of Epilepsy: Hard Evidence at Last? Journal of Epilepsy Research, 7(2), 61–76.
  3. Devinsky, O. et al. (2016). Cannabidiol in Patients With Treatment-Resistant Epilepsy: An Open-Label Interventional Trial. The Lancet: Neurology, 15(3), 270–278.
  4. Mannila, J., Jarvinen, T., Jarvinen, K., Jarho, P. (2007). Precipitation Complexation Method Produces Cannabidiol/Beta-Cyclodextrin Inclusion Complex Suitable for Sublingual Administration of Cannabidiol. Journal of Pharmaceutical Sciences, 96(2), 312–9.
  5. Millar, S.A., Stone, N.L., Yates, A.S. & O’Sullivan, S.E. (2018) A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans. Frontiers in Pharmacology, 9, 1365.
Nina Julia

Nina created CFAH.org following the birth of her second child. She was a science and math teacher for 6 years prior to becoming a parent — teaching in schools in White Plains, New York and later in Paterson, New Jersey.

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13 Best CBD Oils for Seizures

This article contains affiliate links to products. We may receive a commission for purchases made through these links.

If you or someone you know has epilepsy, it’s likely that you have been looking for a natural way to control seizures. In this article, we will explore some of the best CBD oils available right now for treating epilepsy and seizure disorders.

CBD (cannabidiol) is one of many chemical compounds found in cannabis plants. It does not produce any psychoactive effects so it can be safely used by children, adults, and pets without fear of getting high or experiencing side effects.

These benefits aside, there are also numerous studies that show that CBD oil may help with anxiety and depression as well as chronic pain relief without the side effects associated with prescription medications like opioids.

As such, CBD oil is quickly becoming an ideal supplement for those who want to live a healthier and happier life.

What is CBD?

CBD, or cannabidiol, is one of the many active compounds found in cannabis plants. Although it is not psychoactive like THC (tetrahydrocannabinol), CBD has valuable health benefits that have recently attracted the attention of medical professionals around the world for treating conditions that were once deemed untreatable.

The reason why CBD is non-intoxicating is because it does not affect the same pathways as THC. This makes it a much better option for those who are looking to achieve therapeutic benefits without experiencing mind-altering effects that may interfere with their day-to-day tasks.

While research has not yet fully determined all of the health benefits of CBD, studies have shown that this compound is extremely safe, even at high dosages. Even so, most people who are looking for the benefits of CBD oil may not be aware of the best ways to use it for maximum therapeutic benefits.

Does CBD Oil Work for Seizures?

For those who are not aware, there are actually several types of seizures, all of which can be treated using CBD oil. The most well-known form is epilepsy, which occurs in the brain.

Based on some studies, we've learned that CBD does not act on the same pathways as THC, it is actually one of the most ideal options for treating seizures. CBD helps calm electrical and chemical activity in the brain to promote healthy neurological development, which helps prevent seizure attacks.

Of course, you should always talk to your doctor before adding CBD to your regimen. But whether you are looking for a safe alternative option or need relief from epilepsy, CBD oil has been found to be extremely effective as a treatment option with little to no side effects.

Are There Side Effects of CBD Oils?

CBD is no longer viewed as a dangerous and addictive drug like it once was many years ago. Today's CBD products are non-intoxicating and comprised of natural ingredients that actually work with your endocannabinoid system instead of against it.

Even so, some people who are new to CBD oil may experience mild side effects like fatigue, dry mouth, and changes in appetite. If you notice any of these side effects when using CBD for seizures, it is best to only use the recommended dosage on your product's packaging so you can adjust accordingly.

Today we're sharing more about CBD oils for seizures to help you find maximum relief with a more natural product.

Best CBD Oil for Seizures

We have gathered the best cannabidiol (CBD) oils you can try to reduce seizures. Find out how you can choose the right CBD product for your condition.

Spruce 750mg Lab Grade CBD Oil
  1. Peppermint flavor masks any unpleasant taste
  2. Contains 25mg of CBD per dropper full
  3. Bottle includes a graduated dropper for correct serving measurement

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Best CBD Purity

NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
  1. Natural remedy for various illnesses
  2. Product is full-spectrum whole-plant extract
  3. Contains naturally occurring synergistic cannabinoids and terpenes

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Best High Potency

Spruce 2400mg Lab Grade CBD Oil
  1. Maximum possible potency
  2. Each dropper full contains 80mg of CBD
  3. Conveniently fits in a 30mL bottle

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Avida Full Spectrum CBD Oil Tincture 500mg
  1. Proprietary full-spectrum
  2. Developed using advanced AVIDA CORE Spectrum Technology
  3. Highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3)

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cbdMD CBD Oil Tincture Natural 1500mg
  1. Made using only CBD sourced from medical hemp
  2. Available in many flavours
  3. Safe for daily use

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CBDistillery THC Free CBD Oil Tinctures
  1. Do not contain THC
  2. Available in different potencies and sizes
  3. Brand has special deals and offers

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Best Customer Rated

cbdMD CBD Oil Tincture Natural 750mg
  1. THC-free
  2. Has plenty of flavours to choose from
  3. Totally vegan

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Best For Beginners

NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
  1. Lowest concentration for CBD beginners
  2. Fully organic and lab-tested
  3. Full-spectrum

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Best Flavor Range

Hemp Bombs 750mg CBD Oil
  1. Has a wide range of flavours
  2. Safe to intake
  3. Get 20% off when you avail of their subscription

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Best CBD Oil For Seizures 2022

    Editor’s Pick Best Organic Editor’s Pick Best Seller Best Natural Alternative Best THC-Free Best Customer Rated Best Starter Best Flavor Range

Compare the Best CBD Oil for Seizures in 2021

Best CBD Oil for Seizures

1. Spruce 750mg Lab Grade CBD Oil
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Each bottle of the 750mg CBD oil tincture contains 25mg of CBD per dropper full. The oil is peppermint flavor to mask any unpleasant tastes related to CBD.

2. NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
cbdc overall score
CBDC Evaluation Table/Score

Natural remedy for various illnesses. NuLeaf Naturals’ CBD oil is a whole-plant extract containing a full spectrum of naturally occurring synergistic cannabinoids and terpenes.

3. Spruce 2400mg Lab Grade CBD Oil
cbdc overall score
CBDC Evaluation Table/Score

The largest bottle of CBD oil that Spruce offers contains 2,400mg of CBD. This is full-spectrum CBD oil, which is the maximum possible potency. Each high potency dropper full contains 80mg of CBD. There are no flavorings in it, which allows for the most CBD to fit in the 30ml bottle.

4. Avida Full Spectrum CBD Oil Tincture 500mg
cbdc overall score
CBDC Evaluation Table/Score

Avida Extracts Full Spectrum CBD oil is the latest iteration of the brand’s advanced Avida CORE Spectrum technology. They use a proprietary full spectrum blend, resulting in the highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3) to support your health.

5. cbdMD CBD Oil Tincture Natural 1500mg
cbdc overall score
CBDC Evaluation Table/Score

cbdMD’s CBD oil tinctures are made using only CBD sourced from medical hemp and MCT oil as a carrier oil. Tinctures are offered in orange, mint, natural, and berry flavors. Safe for daily use, the oil tinctures are packaged with a built-in rubber dropper to adjust CBD dosage easily. The packaging is made to be easy to transport and discreet to use.

6. CBDistillery THC Free CBD Oil Tinctures
cbdc overall score
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CBDistillery’s Isolate CBD Oil Tinctures harness the power of pure CBD. CBD Isolate Oil Tinctures include 0.0% THC. When you use CBDistillery CBD Isolate Oil Tinctures, you can be assured you’re using the highest quality CBD on the market.

7. NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
cbdc overall score
CBDC Evaluation Table/Score

This is one of several concentrations from NuLeaf Naturals. As the lowest concentration, it is the company’s best option for those new to CBD oil. The product is lab-tested and fully organic. It is full-spectrum, so it contains THC in small quantities.

8. cbdMD CBD Oil Tincture Natural 750mg
cbdc overall score
CBDC Evaluation Table/Score

A 750mg bottle of cbdMD’s Broad Spectrum Oil Tincture does not contain THC. It also has a fairly wide flavor range which is perfect for those who prefer other taste. Vegan consumers are considered since cbdMD offers Vegan products. Aside from all of that, another reason why people love cbdMD is because it’s free from harmful chemicals.

9. Hemp Bombs 750mg CBD Oil
cbdc overall score
CBDC Evaluation Table/Score

Hemp Bombs offer CBD Oil Tinctures that come in a 30ml bottle containing 750mg of CBD. They provide a wide range of flavors perfect for those that have a knack for sweets. Consumers can safely intake this because it’s free of chemicals and pesticides. Hemp Bombs also offer a 20% off on products upon subscription.

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How CBD Helps With Seizures

CBD has been gaining interest as a potential treatment for the medical condition .

In a 2014 study published in Epilepsy and Behavior , CBD reduced the frequency of seizures among patients dealing with treatment-resistant epilepsy (1) .

Treatment-resistant epilepsy is associated with a low quality of life (QOL) (2) . It was suggested that CBD may improve patients’ QOL through effective seizure control (3) .

Seizures are bursts of uncontrolled electrical activity between neurons (brain cells) that cause temporary abnormalities in movements, behaviors, consciousness, or sensations. Meanwhile, epilepsy occurs when an individual has recurring seizures (4) .

The two types of seizures are focal and generalized seizures. Focal or partial seizures start with an electrical discharge in one area of the brain, while generalized seizures can spread to both sides of the brain (5) .

The therapeutic effects of CBD on seizures are realized by CBD’s interaction with the body’s endocannabinoid system (ECS) and its cannabinoid receptors .

The ECS regulates various functions in the body, including immune response, pain sensation, mood, memory processing, metabolism, appetite, anxiety, and sleep.

CB1 and CB2 are the two main types of receptors of the ECS. Each receptor has specific roles and is located in different parts of the body.

CB1 receptors are prevalently expressed in the central nervous system, including the brain. These receptors are also found in the liver, lungs, retina, gastrointestinal and urinary tracts, and reproductive organs (6) .

CB1 receptors ’ activation in the body has been linked to neuroprotective responses (7) .

This mechanism suggests that cannabinoids with a high affinity for CB1 receptors , like CBD, may help prevent and treat neurodegenerative conditions (8) .

Cannabinoids are naturally occurring compounds that may come from the cannabis plant.

Meanwhile, CB2 receptors are mainly situated on the immune system’s cells and their associated structures. When activated, these receptors stimulate a response that reduces pain, fights inflammation, and minimizes tissue damage.

According to a study, CBD compounds have a weak affinity for CB1 and CB2 receptors . CBD’s anti-seizure activity at certain concentrations is brought about by other mechanisms (9) .

The blocking of GPR55 receptors and the reabsorption of adenosine in the brain have been suggested to play a vital role in CBD’s anti-seizure activity (10) .

Adenosine is a neurotransmitter that may stop seizures and convulsions (11) . A 2017 study in the Neuropharmacology journal noted that the therapeutic increase of adenosine prevents epileptic seizures (12) .

GPR55 (G protein-coupled receptor ) is a type of protein found in the brain. A study found that the function of GPR55 receptors was enhanced by epilepsy that made seizures worse (13) .

However, CBD remained adequately potent in epileptic brains, which suggests the anticonvulsant properties of CBD. These anticonvulsant characteristics may be related in part to CBD-mediated modulation of the ECS (14) .

The modulation is done through inhibiting anandamide degradation or decline, resulting in reduced excess brain activity (15) .

Anandamide is an endocannabinoid ( cannabinoids produced within the body) that acts as a neurotransmitter and regulates emotional behavior.

Research noted that endocannabinoids are released by bursts of action potentials, such as seizures or events resembling spikes (16) .

Benefits of Using CBD for Seizures

Studies indicated CBD’s antiepileptic efficacy in acute and chronic seizure rodent models. However, the exact mechanisms of action remain unclear (17) .

In various animal studies, pure CBD used on partial and generalized epilepsy models showed anticonvulsant effects (18) . These studies were conducted on mice, rats, and gerbils.

Meanwhile, open-label studies and small randomized controlled trials of purified CBD in humans with treatment-resistant epilepsy demonstrated mixed results (19) .

A study in the New England Journal of Medicine indicated that CBD use resulted in a significant reduction in convulsive-seizure frequency than placebo among people with Dravet syndrome (20) .

Dravet syndrome is one of the types of epilepsy syndromes that begins in infancy or early childhood. This condition is characterized by frequent or prolonged seizures (21) .

Many of these clinical trials used a product that combines a one-to-one ratio of CBD and tetrahydrocannabinol ( THC ), a compound with known psychoactive effects .

The results of the 2017 study were promising. On average, CBD decreased convulsive seizures from nearly 13 seizures to about six seizures per month (22) .

Meanwhile, the average change with the placebo was from 15 to about 14 seizures per month. A minority of about 5% of patients became seizure-free.

In another randomized, double-blind, placebo -controlled trial in 2018, researchers investigated CBD’s efficacy on the treatment-resistant Lennox-Gastaut syndrome (LGS).

Findings stated that CBD proved efficacious in treating patients (aged 2 to 55 years old) with drop seizures associated with LGS (23) .

Drop seizures, also known as atonic seizures or drop attacks, are characterized by a sudden loss of muscle strength. This type of seizure causes an individual to fall to the ground (24) .

In a 2018 study, the high-dose CBD group experienced an average reduction in the drop-seizure frequency of nearly 42% during the treatment period.

Meanwhile, the low-dose CBD group experienced about 37% reduction while only 17% in the placebo group reported drop seizure reduction .

The researchers also suggested that CBD is generally well-tolerated. However, 74 out of 86 patients reported adverse effects, such as drowsiness , fever, decreased appetite, diarrhea, and vomiting.

The studies on CBD as an additional anticonvulsant in patients with LGS and Dravet syndrome contributed to the decision regarding Epidiolex ’s approval.

Epidiolex is a pharmaceutical-grade purified CBD approved by the US Food and Drug Administration ( FDA ) as an evidence-based remedy for treatment-resistant epileptic syndromes (25) .

Medical professionals’ attitudes regarding the use of CBD for epilepsy treatment appear to be divided (26) . However, d ata about CBD’s benefits in the daily is not available.

CBD Dosage and Delivery Methods for Seizures


CBD dosage for seizures may depend on several factors, such as the patient’s age, seizure type, cause of seizure or epilepsy , and other medications currently taken (27) .

You may start with small amounts of CBD at first, then gradually increase the dosing if there are no adverse effects. Get medical advice from your physician to determine the right CBD dosage for seizures.

A study stated that doses of up to 50 mg CBD are safe. However, a higher permissible amount for CBD treatment cannot be defined due to a lack of data (28) .

  • Starting dosage: 2.5mg CBD per kilogram of the body weight by mouth twice daily
  • Maintenance dosage: 5mg CBD per kilogram of the body weight by mouth twice daily
  • Maximum maintenance dosage: 10mg CBD per kilogram of the body weight by mouth twice daily

Methods of Delivery

Oral administration is recommended for people with seizures, especially those with Dravet and Lennox-Gastaut syndrome . Epidiolex is an oral solution that involves placing the liquid in the mouth (30) .

Tinctures may be applied through sublingual administration by placing a few drops of CBD oil under your tongue with a dropper. This method allows CBD to be absorbed into the bloodstream.

According to a review published in the International Journal of Pharmacy and Pharmaceutical Sciences , most substances administered sublingually achieve peak blood levels ( the drug’s highest level of concentration in the bloodstream) within 10 to 15 minutes, which is faster than oral ingestion (31) .

Additionally, the sublingual method is an efficient way to take CBD oil. Studies report that the sublingual form has a bioavailability of 13% to 19% and 35% (32) .

Bioavailability is known as the rate and degree at which the body absorbs a drug.

CBD oil may be ingested through edibles, gummies , or added to other food and beverages. This method allows CBD to be absorbed through the digestive tract.

CBD-infused topicals may also be used in massage therapies. However, this method provides limited absorption through the skin (33) .

The Epilepsy Society in the United Kingdom stated that complementary therapies, like massages and herbal remedies, may reduce stress, promote well – being, and be used with any antiepileptic drugs taken by an individual (34) .

Vaping provides a quick way of getting CBD into the body (35) . After inhaling CBD, it enters the bloodstream by passing through the lungs.

The effects of CBD may be felt within minutes and may last up to four hours (36) . However, it may be challenging to determine the exact amount of CBD in each draw of vape .

The use of vape should be done with caution , especially for patients with seizures. Experts believe that vaping may cause lung problems due to allergic or immune reactions and chemical irritation to various substances in the inhaled vapors (37) .

CBD vs. Other Treatment Options for Seizures

Prescribed medications and surgical techniques may control seizures in 70% of individuals with epilepsy – seizure disorders . However, there is no available treatment of seizures in some forms of epilepsy (38) .

  • Getting seven to eight hours of sleep.
  • Keeping a well-balanced diet and maintaining a healthy weight.
  • Finding outlets to relieve stress and seeking professional help for mental health issues.

Multiple studies highlighted CBD’s potential therapeutic properties that may help with these self-management techniques for seizures.

A 2017 study noted that CBD may induce restful sleep and hold promise in the treatment of insomnia (40) .

Full-spectrum CBD derived from hemp contains omega-3 fatty acids. A study observed that administering supplements with omega-3 and omega-6 fatty acids resulted in reduced seizures in patients with refractory epilepsy (41) .

Another study indicated that CBD ha d anti-anxiety and antiepileptic effects on the brain that may help with anxiety and depression (42) .

Risks and Side Effects of CBD for Seizures

The World Health Organization (WHO) indicated that CBD is generally safe to use (43) . However, the possible side effects of CBD may include nausea, dry mouth, fatigue, diarrhea, changes in weight or appetite, and gastrointestinal problems (44) .

The FDA -approved CBD drug for epilepsy , Epidiolex , may also come with mild or severe side effects . Some of the adverse reactions to Epidiolex include malaise (feeling of weakness), skin rash, insomnia, and viral or fungal infections (45) .

In clinical studies, liver damage occurred in people who took Epidiolex . It was noted that between 8% and 25% of people had high levels of liver enzymes (46) .

Studies also showed that CBD may interact with certain seizure medications , including clobazam (Sympazan and Onfi), diazepam (Diastat and Valium), valproate or valproic acid, and phenytoin (Dilantin and Phenytek) (47) .

Data suggested that CBD may reduce the effects of the said medications and increase some side effects (48) .

If you are considering CBD oil for seizures, talk to your doctor to know if CBD can be taken with your prescribed medications.

How to Choose the Best CBD Oil for Seizures

Before purchasing CBD oil for seizures, you should know the three types: full-spectrum, broad-spectrum , and CBD isolates .

Full-spectrum CBD contains all nutrients from the Cannabis sativa plant, including trace amounts of THC , terpenes , fatty acids, flavonoids, and essential oils. The combination of these compounds synergizes to create an entourage effect .

This phenomenon occurs when all components work together to achieve more than the sum of what the same components could achieve individually (49) . The entourage effect is believed to enhance CBD’s health benefits (50) .

For individuals with seizures who do not prefer trace amounts of THC in their system, broad-spectrum CBD may be used. This type of CBD oil is similar to full-spectrum CBD without the THC compound.

If you are allergic to certain compounds of the cannabis plant , you may opt for CBD isolates . This type of CBD oil carries pure, isolated cannabidiol only.

You should also know the differences between hempseed oil and hemp oil . Hempseed oil is obtained from hemp seeds and may have little to no THC content, while hemp oil is extracted from the oil of the hemp plant .

  • Choose quality products made from non- GMO , organic hemp, and manufactured by legitimate CBD brands.
  • Some CBD companies grow their hemp or source it from licensed hemp producers. The most common sources of hemp are Colorado and Oregon.
  • Know the method of extraction used in the CBD product . According to a study, the FDA recognizes supercritical CO 2 extraction as a safe process in pharmaceutical manufacturing (51) .
  • The standard carrier oils used in CBD oil include hemp seed oil, MCT (medium-chain triglycerides), and extra-virgin olive oil.
  • CBD oil products should be tested by an accredited third-party laboratory. Companies should provide the results on their website to ensure the absence of pesticides , heavy metals, bacteria, and residual solvents.
  • See if the third-party lab results match the CBD company’s claims about the potency of its products.
  • You may also look for certification codes in CBD products . These codes determine if the product is screened and approved by the authorities.
  • Get advice from a healthcare professional regarding the proper dosage and recommended form of CBD to use for your condition.
  • Research on the brand and read customer reviews when buying from an online store.
  • If you are buying from a dispensary or local retailer, make sure that the store is authorized by the government to sell CBD products .
  • Know the laws regarding CBD in the state where you will purchase and use it.

Legality of CBD

Hemp and hemp-derived CBD products with less than 0.3 % THC are federally legal under the United States 2018 Farm Bill (52) .

Industrial hemp is removed as a Schedule I drug from the Controlled Substances Act. Drugs under this category have no acceptable medical use and have a high potential for abuse (53) .

The Farm Bill of 2018 also lifted federal restrictions surrounding CBD to allow the cultivation, manufactur e , and sale of CBD products . However, state laws may vary regarding CBD with high THC content (54) .

Individuals are required to follow the requirements outlined in a state’s medical marijuana program.

Qualifying patients may purchase and use medical cannabis if they have an official diagnosis and recommendation from their physician (55) .

Product Frequently
Asked Questions

Research suggested that CBD has anticonvulsant properties that work with the body’s endocannabinoid system . This mechanism helps with CBD’s anti-seizure activity (56) .

According to studies, CBD showed efficacy in the treatment of epilepsy with its anti-seizure, antipsychotic, and neuroprotective properties. The study’s r esearchers also noted that CBD possessed anxiolytic and antidepressant characteristics (57) .

In a study published in Neurology , refractory pediatric epilepsy patients who took artisanal or store-bought CBD reported a 70% increase in seizures and side effects (58) .

Unlike pharmaceutical-grade CBD ( Epidiolex ), artisanal CBD may have varying THC levels and may not have undergone testing. These factors could contribute to the increase in seizure activity (59) .

CBD has the potential to interact with seizure medications , such as clobazam (Sympazan and Onfi), diazepam (Diastat and Valium), phenytoin (Dilantin and Phenytek), and valproate or valproic acid (60) .

Aside from taking CBD, you may consider different self-management techniques to help with seizures. These techniques include getting enough hours of sleep, following a well-balanced diet, and reducing your stress levels.

CBD products with high amounts of THC may show up in a drug test. It is also important to note that even if your CBD oil contains trace amounts of THC only , the compound may accumulate in your body over time with frequent use (61) .

The general rule for CBD dosage is to begin with a low dose of CBD and slowly increase the amount. It is advisable to consult a physician to determine a suitable dosage for your needs.

Epidiolex , an FDA -approved CBD drug for rare forms of epilepsy , may be purchased from pharmacies with a doctor’s prescription (62) . You may also find CBD oil products for seizures in local dispensaries, retailers, and official online stores.

There are different requirements regarding the purchase of medical cannabis , depending on the state’s law.

In most states, you need a diagnosis from a licensed physician indicating that you have a qualifying medical condition and a recommendation to use CBD-rich oils (63) .