topical cbd oil for arthritis


Cannabidiol (CBD) oil is extracted from the leaves, stems, and flower of the hemp plant. In addition to the CBD oil itself, this extract includes minor cannabinoids, flavonoids and terpenes that work together to provide additional health benefits. This is referred to as the “entourage effect.” The entourage effect of full-spectrum CBD oil allows each compound to work better together.

But how does it work?

The endocannabinoid system is the largest system in the body. It functions as a feedback or adaptive system through cellular signaling or communication. This system has two primary types of receptors (CB1 and CB2) that connect to the brain, peripheral nervous system, and immune system, Research has revealed there are a lot more receptors that are modulated by plant cannabinoids too, like TRPV1 and 2, PPARS, GPC55, GPR18, GPC119, CBD is an agonist of the 5-HT1A receptor also. Your CB1 receptors affect things like mood, appetite, and memory. CB2 receptors in the immune system govern your pain and inflammation response. CBD oil supports these receptors not only to control pain and inflammation, but also to prompt the body to release more natural cannabinoids.

Unlike THC, which works on the CB1 receptors, CBD oil is non-intoxicating and does not produce the stereotypical “high.”


CBD capitalizes on many potential health benefits. To start the properties of CBD may help relieve inflammation and pain due to the following conditions:

  • Arthritis
  • Fibromyalgia
  • Osteoarthritis
  • Rheumatoid arthritis

The compounds in the hemp plant and a full spectrum CBD oil like Seed2System’s have strong antioxidant properties, anti-inflammatory and neuroprotective properties. This could be why people report so many anecdotal successes.


Research is discovering that CBD works on pain and inflammation in a variety of ways. The latest research suggests that:

  • CBD oil suppresses chronic pain and inflammation by supporting better function in the alpha-3 glycine receptors
  • Absorption of anandamide, a natural cannabinoid, may relieve pain
  • CBD for arthritis pain controls inflammation and the perception of pain by activating the vanilloid receptor TRPV1
  • Osteoarthritis joint pain and inflammation was decreased when pain sensory neurons signaling was reduced
  • Transdermal CBD oil for joint pain decreased swelling and pain in the knee joint in animal models
  • CBD oil lowers glutamate levels in the brain, a chemical associated with pain and inflammation

You may take CBD oil for joint pain in a number of ways, including tinctures, capsules and topical salves. This is how each delivery method works. With each of these, work with your doctor to find the best dosage and method.


Tinctures are concentrated forms of CBD oil usually found in one- or two-ounce bottles. The most common delivery systems are a spray or dropper that you may use as needed.

Seed2System offers two flavors of our tinctures, mint or a natural flavor. Our 600 mg bottle is good for those just beginning to explore the potential benefits of CBD oil for joint pain, and our 1500 mg tincture may help with ongoing management of chronic pain conditions.


Topical CBD salves are applied directly to skin. This type of application works well not only for inflammation that is contributing to pain but also for sore muscles and recovery. Massage into the skin or sore joint. Apply frequently or as needed.

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Many topicals, like our cayenne peppermint and lavender CBD slaves , also contain other beneficial herbs and extracts, including:

  • Arnica—works on inflammation
  • Peppermint—soothes fatigued or inflamed muscles
  • Cayenne—contains capsaicin which may alleviate joint pain
  • Lavender—provides relaxing relief to reduce pain

WHAT’S THE BEST CBD SERVING SIZE? Many people using CBD oil wonder what the correct serving is for them. At Seed2System, we know that the best serving is the one that works for each individual person. Everyone’s body responds to plants differently, and CBD for joint pain is no exception.

If they occur at all, CBD side effects are minimal. It’s important to work closely with your doctor to find the right serving for you. In addition to helping you find the best serving, your doctor may evaluate any potential adverse interactions with other medications you may be taking. It’s always best to start with a lower serving and then work your way up, if unsure.

It’s also crucial to discuss using CBD oil with your employer. Although CBD oil with very low amounts of THC is legal, it is possible that it will show up on a drug test. If you work in an occupation that has regular and required drug testing, make sure your employer is aware of your treatment plan and responds accordingly.


At Seed2System , we craft our CBD oil from the seeds we grow all the way to the final product in your hand.

It’s important to us that you get the best, full-spectrum CBD oil to support your health, and that includes the way we extract our oils. We use the vapor distillation process, which means that no chemicals or solvents ever enter our products. This results in a clean, nutty-tasting oil that contains no additional sweeteners or artificial flavors. It also captures the natural flavonoids and terpenes of the hemp plant.

If you are looking for the best full-spectrum CBD oil but don’t know which is right for you, get in touch today. At Seed2System, we love to help our customers find the best product for their needs.

I Tried a Bunch of CBD Topicals to Find the Best Solution for My Creaky Ass

My feet are bad. Really bad. I blame my grandfather, whose feet were so flat that he wasn’t able to join the army in World War II, and was instead rerouted to the Merchant Marines, where he was stationed as a radio officer. While I didn’t inherit his desire to enlist, I did receive his cursed flatness, which, combined with various injuries over the course of my reckless life, including falling down the stairs years ago and breaking my ankle while in an altered state (ironic, considering where this is going), means that I’ve dealt with a lot of pain. Across my years of inflammation, arthritis, and even sporadic episodes of gout, I’ve sought a breadth of solutions, including visits to orthopedic surgeons and physicians, X-rays, physical therapy, excessive use of various kinds of herbal gels and creams (like arnica), industrial-level anti-inflammatory pharmaceuticals, ankle braces, orthotics, boots, and more. The amount of time and money I’ve spent on my feet is honestly staggering, and I’ve basically lost faith that the medical establishment can do anything for me at all. 

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I Tried a CBD Sports Drink That Promises to Make Exercising Suck Less

In spite of all this, I try to stay athletic, and have found that a healthy mix of pilates, cycling, and strength training helps me stay strong and maximally resistant to injury and pain… though those things still do happen. Most recently, a change in cycling cleats led to a wild foot cramp that turned into a massive gout explosion, sidelining me for over two weeks. After finally RICE-ing it away (with the addition of a ton of ibuprofen), I was left with a serious knot in my foot that would not disappear. Let’s pause here and back up a bit. 

I’ve recently been awakened to the divine power of CBD, a.k.a. cannabidiol, the chemical compound extracted from cannabis that’s currently experiencing skyrocketing popularity as well as scientific curiosity (and skepticism). After swearing off weed (and basically everything else) more than half a decade ago, I figured I had left the thrills of youth behind, settling into a mellow, grown-up life of simply drinking a lot of wine. However, one night last summer, a friend convinced me to try CBD. He said it could make me feel relaxed and not high (because it's isolated from THC, it's non-psychoactive), but that most likely I wouldn't feel it at all, and for some reason that would be a good thing. He insisted I take two 5-milligram gummies, which together consituted one “dose.” The baby that I am, I haggled it down to half of one gummy for my first outing and indeed felt nothing after taking it. But I later experimented with higher doses and different forms of delivery (like oils), and became a believer in CBD’s power to help me chill out without feeling stoned. In addition to its purported success with anxiety, I was also vaguely aware of its other legacy as an alleged magical cure-all for local pain. One of my friends told me that her parents had become obsessed with CBD for its anti-inflammatory properties, while another took it daily to stave off aches and pains from working out. Online, I’d frequently seen celebs and athletes like plant-based Ironman and esteemed hardcore legend John Joseph of Cro-Mags preaching CBD as a mighty recovery tool. If he was into it, I thought it may be worth a try.

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So when my most recent inflammation attack wouldn’t go away, I was quick to add some CBD cream into my healing regimen, and I’ll be damned if it didn’t eradicate that hellish knot basically overnight. I was thrilled, but also left with questions. Why did this work when nothing else did? Was I treating the injury and inflammation, or just the pain? Was there a difference? Unable to find answers online, I went to one of the country’s esteemed experts on CBD and its medical uses, Dr. Peter Grinspoon, instructor at Harvard Medical School and physician at Massachusetts General Hospital. 

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According to Dr. Grinspoon, there isn’t really a divide between pain and inflammation—they’re two sides of the same coin. And, he says, CBD can be very successful at managing both for many patients. “CBD has a very potent anti-inflammatory effect,” he explained. “It suppresses cytokines and interleukins, and so it helps turn off the body’s hyperreactive response to the injury that helps perpetuate the inflammatory response, which contributes to pain.” So a reduction in inflammation can also promote healing of the injury.

When one has determined that an injury is nothing serious like a bone break or a torn meniscus, Dr. Grinspoon actually recommends starting with CBD topicals to treat mild-to-moderate pain; in his view, Tylenol or ibuprofen should be thought of as secondary and always short-term options. “If people have, like, chronic back strain, it would be great if they tried some CBD cream before they reached for the ibuprofen. It’s just safer,” he said. “People are so quick to reach for these pharmaceuticals, ones we’ve been taking for decades. People just assume that if it’s over-the-counter, it’s safe, but some of them aren’t safe.” He added that every year, there are actually tens of thousands of injuries (like kidney damage and stomach ulcerations) caused by non-steroidals like naprosyn, naproxen, and ibuprofen (found in over-the-counter drugs including Aleve and Advil). “I’m guessing that ten years from now, people are going to be reaching for cannabis cream and CBD cream first,” he mused. 

Dr. Grinspoon prefers not to recommend specific brands and products, instead wanting to give people the tools to become savvy CBD shoppers on their own. He is also quick to warn that the current lack of regulation in the industry means that efficacy can be inconsistent, and many brands and products remain unreliable. “Don’t just go to the gas station and buy CBD,” he told me. “One of the problems is that it’s not regulated. You just have to read everything about CBD with a bit of grain of salt.” He pointed out that, at the very least, one should always aim for CBD that has been independently tested and has received a Certificate of Analysis.

With all of this new knowledge, I let his wisdom guide me as I went deeper down the rabbit hole, searching for the ultimate CBD topical. 

One product I can definitely vouch for is the one that healed my foot: Charlotte’s Web/CBDMedic Arthritis Aches & Pain Relief Ointment. (I love Charlotte’s Web and have also had great experiences with their recovery gummies, which I like to take after a demanding ride). With 200 milligrams of CBD hemp extract per tube and plenty of good herbal additions like eucalyptus, lavender, and jojoba oils—Dr. Grinspoon confirmed that people have been using herbal medicines like these to some effect for hundreds of years—as well as 10-percent menthol for a dope-feeling and quick-acting cooling sensation, this one is solid.