Clinical trials for cbd oil and pain
The Lambert Initiative is researching the application of phytocannabinoids to assist in the treatment and management of chronic and neuropathic pain.
Cannabidiol for chronic pain caused by spinal cord injury
This research project will investigate the chronic pain that commonly occurs after spinal cord injury.
The first part of the study will compare brain images of individuals who develop chronic pain after spinal cord injury to those who do not. This will help determine underlying brain changes responsible for the chronic neuropathic pain. In the second part of the study, a randomised, double-blind placebo-controlled study will be used to investigate cannabidiol’s ability to reduce pain.
This is a collaboration between the Lambert Initiative for Cannabinoid Therapeutics, the Brain and Mind Centre and the School of Medical Sciences at the University of Sydney.
Chief Investigator: Professor Luke Henderson (Brain and Mind Centre, School of Medical Sciences, University of Sydney)
Research Team: Professor Iain McGregor (Lambert Initiative, University of Sydney), Dr Elizabeth Cairns (Lambert Initiative, University of Sydney), and Dr Sachin Shetty (Prince of Wales hospital).
If you are interested in participating in this study, register your interest by contacting Professor Henderson by phone (02 9351 7063) or email ([email protected]).
Cannabis in a mouse neuropathic pain model (completed, 2018)
Cannabis and THC have efficacy against neuropathic pain, however, this is hampered by their side effects. It has been suggested that co-administration with CBD might enhance the analgesic actions of THC and minimise its deleterious side effects. We examined the basis for this phytocannabinoid interaction in a mouse model of neuropathic pain.
Results: We found that THC and CBD reduced neuropathic pain. CBD had no adverse side effects. The 1:1 combination of THC and CBD synergistically reduced neuropathic pain with 100-fold greater efficacy than predicted from an additive interaction. THC also synergistically enhanced the efficacy of current first-line neuropathic pain treatments gabapentin and duloxetine.
This was a collaboration between the Lambert Initiative for Cannabinoid Therapeutics at the University of Sydney; the Kolling Institute; Royal North Shore Hospital; the Pain Management Research Institute at the University of Sydney, and the Northern Clinical School at the University of Sydney.
Research Team: Dr Chris Vaughan (University of Sydney); Professor Iain McGregor, Associate Professor Jonathon Arnold (Lambert Initiative, University of Sydney)
A Guide To Cannabidiol (CBD) Clinical Trials
BD is the second most common active compound within the marijuana plant. It can be derived in relatively large quantities from hemp to be used for medical treatment. CBD has many potential applications for sufferers of chronic disease.
CBD has rapidly become a popular area of medical study for several reasons. First, it does not produce a high in patients who use it. Second, it does not appear to cause any symptoms of chemical dependency. A low potential for abuse or addiction makes it highly promising.
Match to Cannabidiol Clinical Trials
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What Conditions Can CBD Treat or Cure?
CBD has a very long history as a treatment for those suffering from intense chronic pain. In particular, it is valuable for patients who cannot benefit from traditional medications as a result of damaged organs or a compromised immune system.
Doctors have been prescribing CBD for patients with advanced cancer or AIDS for many years. CBD can be helpful in reducing pain related to anti-cancer treatments such as chemotherapy. It may also temporarily improve or restore patients’ appetite.
More recently, CBD has been shown to have powerful effects on some patients suffering from seizure disorders. CBD-based treatments have been accepted as highly safe and effective for some younger patients whose epilepsy is resistant to conventional treatment.
The positive effects of CBD on individuals with other conditions is also being studied. These studies include psoriasis, multiple sclerosis, Parkinson’s disease, and as a potential treatment to preventing cancer cell growth.
What Research Currently Exists Around CBD?
Because CBD has only recently entered the medical mainstream, there are still many unanswered questions to be explored. Early research focused on the role of cannabinoid receptors in the brain in perceiving and processing CBD, as well as its effect on the brain’s production of dopamine.
Over the last few years, doctors have launched small-scale CBD studies and CBD clinical trials to find other potential uses for the compound. CBD is gaining notoriety as a potential treatment for a variety of mood disorders, especially generalized anxiety. It may even help PTSD sufferers.
Naturally, there is still much to learn about CBD. No long-term (“longitudinal”) study has shown the effects of CBD on brain structure or quality of life. It will be some time before a large enough patient community exists for a multi-decade CBD clinical study to be completed.
Why Are Further CBD Clinical Trials Important?
CBD is a substance humans have been in contact with for centuries. However, we know relatively little about its potential applications in modern medicine. Much of the data that exists is for older patients and those who have suffered chronic conditions for many years.
Promising CBD medical discoveries point to the possibility that it might be useful for a wide range of conditions throughout life. The better doctors come to understand how CBD affects the perception of pain, the easier it will be to prescribe effective and safe doses.
CBD can be refined to be very mild or very potent. It can also be introduced into the body in a whole spectrum of ways. Further CBD clinical trials are needed to gain a full understanding of the best way for patients to use CBD based on their health situation.
Current CBD Clinical Trials
The following CBD trials are the most up to date known to ClinicalTrials.gov. If you would like to showcase a clinical study on this page, contact our team.
ClinicalTrials.gov: Recruiting Studies | Cannabidiol | Last update posted in the last 300 days Studies found on ClinicalTrials.gov by a search of: Recruiting Studies | Cannabidiol | Last update posted in the last 300 days
Condition: InsomniaInterventions: Drug: Defined CBD; Drug: PlaceboSponsor: Defined ResearchRecruiting
Conditions: Healthy; Safety IssuesInterventions: Dietary Supplement: Cannabinol; Other: PlaceboSponsors: University of South Carolina; CBD Industries, LLCRecruiting
Condition: Opioid Use DisorderIntervention: Drug: Morphine SulfateSponsor: National Institute on Drug Abuse (NIDA)Recruiting
Conditions: Posttraumatic Stress Disorder; Stress Disorders, Post-TraumaticInterventions: Drug: Cannabidiol (CBD) oral solution; Drug: Placebo; Behavioral: Massed Prolonged Exposure (mPE)Sponsor: The University of Texas Health Science Center at San AntonioRecruiting
Conditions: Bladder, Overactive; Parkinson DiseaseIntervention: Drug: Medical CannabisSponsor: Sheba Medical CenterRecruiting
Condition: AddictionInterventions: Drug: CBD Day 1; Drug: CBD Day 2; Drug: CBD Day 3Sponsor: Yale UniversityRecruiting
Conditions: Back Pain; Depressive SymptomsInterventions: Drug: CBD; Other: PlaceboSponsor: Massachusetts General HospitalRecruiting
Conditions: Lennox Gastaut Syndrome; Dravet Syndrome; Tuberous Sclerosis ComplexIntervention: Drug: CannabidiolSponsor: Jazz PharmaceuticalsRecruiting
Condition: Mild Cognitive ImpairmentInterventions: Drug: Cannabidiol Oil; Drug: HomotaurineSponsors: Aristotle University Of Thessaloniki; Greek Alzheimer’s Association and Related DisordersRecruiting
Condition: HealthyIntervention: Drug: CannabidiolSponsor: Hurd,Yasmin, Ph.D.Recruiting
Condition: Osteoarthritis, KneeInterventions: Drug: CBD/CBN; Drug: CBD/THC; Drug: PlaceboSponsor: Pure GreenRecruiting
Conditions: Osteoarthritis, Knee; Osteoarthritis of the KneeInterventions: Drug: Placebo; Drug: Cannabidiol (CBD); Drug: Tetrahydrocannabinol (Marinol® or generic equivalent (e.g., dronabinol)Sponsors: Richard Harris; National Center for Complementary and Integrative Health (NCCIH); National Institute on Drug Abuse (NIDA)Recruiting
As time goes on, medical research into CBD is uncovering how to reduce side effects and ensure safety when CBD is used alongside conventional medication. In years to come, CBD may take a place as one of the most valuable treatments for childhood epilepsy, chronic pain, and even many treatment-resistant mood disorders experienced by millions of Americans.