cbd oil for women anxiety

Cbd oil for women anxiety

Context: Cannabidiol (CBD) is one of many cannabinoid compounds found in cannabis. It does not appear to alter consciousness or trigger a “high.” A recent surge in scientific publications has found preclinical and clinical evidence documenting value for CBD in some neuropsychiatric disorders, including epilepsy, anxiety, and schizophrenia. Evidence points toward a calming effect for CBD in the central nervous system. Interest in CBD as a treatment of a wide range of disorders has exploded, yet few clinical studies of CBD exist in the psychiatric literature.
Objective: To determine whether CBD helps improve sleep and/or anxiety in a clinical population.
Design: A large retrospective case series at a psychiatric clinic involving clinical application of CBD for anxiety and sleep complaints as an adjunct to usual treatment. The retrospective chart review included monthly documentation of anxiety and sleep quality in 103 adult patients.
Main Outcome Measures: Sleep and anxiety scores, using validated instruments, at baseline and after CBD treatment.
Results: The final sample consisted of 72 adults presenting with primary concerns of anxiety (n = 47) or poor sleep (n = 25). Anxiety scores decreased within the first month in 57 patients (79.2%) and remained decreased during the study duration. Sleep scores improved within the first month in 48 patients (66.7%) but fluctuated over time. In this chart review, CBD was well tolerated in all but 3 patients.
Conclusion: Cannabidiol may hold benefit for anxiety-related disorders. Controlled clinical studies are needed.


The Cannabis plant has been cultivated and used for its medicinal and industrial benefits dating back to ancient times. Cannabis sativa and Cannabis indica are the 2 main species. 1 The Cannabis plant contains more than 80 different chemicals known as cannabinoids. The most abundant cannabinoid, tetrahydrocannabinol (THC), is well known for its psychoactive properties, whereas cannabidiol (CBD) is the second-most abundant and is nonpsychoactive. Different strains of the plant are grown containing varying amounts of THC and CBD. Hemp plants are grown for their fibers and high levels of CBD that can be extracted to make oil, but marijuana plants grown for recreational use have higher concentrations of THC compared with CBD. 2 Industrial hemp must contain less than 0.3% THC to be considered legal, and it is from this plant that CBD oil is extracted. 3

Many different cultures have used the Cannabis plant to treat a plethora of ailments. Practitioners in ancient China targeted malaria, menstrual symptoms, gout, and constipation. During medieval times, cannabis was used for pain, epilepsy, nausea, and vomiting, and in Western medicine it was commonly used as an analgesic. 4,5 In the US, physicians prescribed Cannabis sativa for a multitude of illnesses until restrictions were put in place in the 1930s and then finally stopped using it in 1970 when the federal government listed marijuana as a Schedule I substance, claiming it an illegal substance with no medical value. California was the first state to go against the federal ban and legalize medical marijuana in 1996. 6 As of June 2018, 9 states and Washington, DC, have legalized recreational marijuana, and 30 states and Washington, DC, allow for use of medical marijuana. 7 The purpose of the present study is to describe the effects of CBD on anxiety and sleep among patients in a clinic presenting with anxiety or sleep as a primary concern.

CBD has demonstrated preliminary efficacy for a range of physical and mental health care problems. In the decade before 2012, there were only 9 published studies on the use of cannabinoids for medicinal treatment of pain; since then, 30 articles have been published on this topic, according to a PubMed search conducted in December 2017. Most notable was a study conducted at the University of California, San Diego’s Center for Medicinal Cannabis Research that showed cannabis cigarettes reduced pain by 34% to 40% compared with placebo (17% to 20% decrease in pain). 8 In particular, CBD appears to hold benefits for a wide range of neurologic disorders, including decreasing major seizures. A recent large, well-controlled study of pediatric epilepsy documented a beneficial effect of CBD in reducing seizure frequency by more than 50%. 9 In addition to endorphin release, the “runner’s high” experience after exercise has been shown to be induced in part by anandamide acting on CB1 receptors, eliciting anxiolytic effects on the body. 10 The activity of CBD at 5-HT1A receptors may drive its neuroprotective, antidepressive, and anxiolytic benefits, although the mechanism of action by which CBD decreases anxiety is still unclear. 11 CBD was shown to be helpful for decreasing anxiety through a simulated public speaking test at doses of 300 mg to 600 mg in single-dose studies. 12-14 Other studies suggest lower doses of 10 mg/kg having a more anxiolytic effect than higher doses of 100 mg/kg in rats. 15 A crossover study comparing CBD with nitrazepam found that high-dose CBD at 160 mg increased the duration of sleep. 16 Another crossover study showed that plasma cortisol levels decreased more significantly when given oral CBD, 300 to 600 mg, but these patients experienced a sedative effect. 17 The higher doses of CBD that studies suggest are therapeutic for anxiety, insomnia, and epilepsy may also increase mental sedation. 16 Administration of CBD via different routes and long-term use of 10 mg/d to 400 mg/d did not create a toxic effect on patients. Doses up to 1500 mg/d have been well tolerated in the literature. 18 Most of the research done has been in animal models and has shown potential benefit, but clinical data from randomized controlled experiments remain limited.

Finally, the most notable benefit of cannabis as a form of treatment is safety. There have been no reports of lethal overdose with either of the cannabinoids and, outside of concerns over abuse, major complications are very limited. 19 Current research indicates that cannabis has a low overall risk with short-term use, but more research is needed to clarify possible long-term risks and harms.

Given the promising biochemical, physiologic, and preclinical data on CBD, a remarkable lack of randomized clinical trials and other formal clinical studies exist in the psychiatric arena. The present study describes a series of patients using CBD for treatment of anxiety or sleep disturbances in a clinical practice setting. Given the paucity of data in this area, clinical observations can be quite useful to advance the knowledge base and to offer questions for further investigation. This study aimed to determine whether CBD is helpful for improving sleep and/or anxiety in a clinical population. Given the novel nature of this treatment, our study also focused on tolerability and safety concerns. As a part of the evolving legal status of cannabis, our investigation also looked at patient acceptance.


Design and Procedures

A retrospective chart review was conducted of adult psychiatric patients treated with CBD for anxiety or sleep as an adjunct to treatment as usual at a large psychiatric outpatient clinic. Any current psychiatric patient with a diagnosis by a mental health professional (psychiatrist, psychiatric nurse practitioner, or physician assistant) of a sleep or anxiety disorder was considered. Diagnosis was made by clinical evaluation followed by baseline psychologic measures. These measures were repeated monthly. Comorbid psychiatric illnesses were not a basis for exclusion. Accordingly, other psychiatric medications were administered as per routine patient care. Selection for the case series was contingent on informed consent to be treated with CBD for 1 of these 2 disorders and at least 1 month of active treatment with CBD. Patients treated with CBD were provided with psychiatric care and medications as usual. Most patients continued to receive their psychiatric medications. The patient population mirrored the clinic population at large with the exception that it was younger.

Nearly all patients were given CBD 25 mg/d in capsule form. If anxiety complaints predominated, the dosing was every morning, after breakfast. If sleep complaints predominated, the dosing was every evening, after dinner. A handful of patients were given CBD 50 mg/d or 75 mg/d. One patient with a trauma history and schizoaffective disorder received a CBD dosage that was gradually increased to 175 mg/d.

Often CBD was employed as a method to avoid or to reduce psychiatric medications. The CBD selection and dosing reflected the individual practitioner’s clinical preference. Informed consent was obtained for each patient who was treated and considered for this study. Monthly visits included clinical evaluation and documentation of patients’ anxiety and sleep status using validated measures. CBD was added to care, dropped from care, or refused as per individual patient and practitioner preference. The Western Institutional Review Board, Puyallup, WA, approved this retrospective chart review.

Setting and Sample

Wholeness Center is a large mental health clinic in Fort Collins, CO, that focuses on integrative medicine and psychiatry. Practitioners from a range of disciplines (psychiatry, naturopathy, acupuncture, neurofeedback, yoga, etc) work together in a collaborative and cross-disciplinary environment. CBD had been widely incorporated into clinical care at Wholeness Center a few years before this study, on the basis of existing research and patient experience.

The sampling frame consisted of 103 adult patients who were consecutively treated with CBD at our psychiatric outpatient clinic. Eighty-two (79.6%) of the 103 adult patients had a documented anxiety or sleep disorder diagnosis. Patients with sole or primary diagnoses of schizophrenia, posttraumatic stress disorder, and agitated depression were excluded. Ten patients were further excluded because they had only 1 documented visit, with no follow-up assessment. The final sample consisted of 72 adult patients presenting with primary concerns of anxiety (65.3%; n = 47) or poor sleep (34.7%; n = 25) and who had at least 1 follow-up visit after CBD was prescribed.

Main Outcome Measures

Sleep and anxiety were the targets of this descriptive report. Sleep concerns were tracked at monthly visits using the Pittsburg Sleep Quality Index. Anxiety levels were monitored at monthly visits using the Hamilton Anxiety Rating Scale. Both scales are nonproprietary. The Hamilton Anxiety Rating Scale is a widely used and validated anxiety measure with 14 individual questions. It was first used in 1959 and covers a wide range of anxiety-related concerns. The score ranges from 0 to 56. A score under 17 indicates mild anxiety, and a score above 25 indicates severe anxiety. The Pittsburg Sleep Quality Index is a self-report measure that assesses the quality of sleep during a 1-month period. It consists of 19 items that have been found to be reliable and valid in the assessment of a range of sleep-related problems. Each item is rated 0 to 3 and yields a total score from 0 to 21. A higher number indicates more sleep-related concerns. A score of 5 or greater indicates a “poor sleeper.”

Side effects and tolerability of CBD treatment were assessed through spontaneous patient self-reports and were documented in case records. Any other spontaneous comments or complaints of patients were also documented in case records and included in this analysis.

Data Analysis

Deidentified patient data were evaluated using descriptive statistics and plotted graphically for visual analysis and interpretation of trends.


The average age for patients with anxiety was 34 years (range = 18-70 years) and age 36.5 years for patients with sleep disorders (range = 18-72 years). Most patients with an anxiety diagnosis were men (59.6%, 28/47), whereas more sleep-disordered patients were women (64.0%, 16/25). All 72 patients completed sleep and anxiety assessments at the onset of CBD treatment and at the first monthly follow-up. By the second monthly follow-up, 41 patients (56.9%) remained on CBD treatment and completed assessments; 27 patients (37.5%) remained on CBD treatment at the third monthly assessment.

Table 1 provides means and standard deviations for sleep and anxiety scores at baseline and during the follow-up period for adults taking CBD. Figure 1 graphically displays the trend in anxiety and sleep scores over the study period. On average, anxiety and sleep improved for most patients, and these improvements were sustained over time. At the first monthly assessment after the start of CBD treatment, 79.2% (57/72) and 66.7% (48/72) of all patients experienced an improvement in anxiety and sleep, respectively; 15.3% (11/72) and 25.0% (18/72) experienced worsening symptoms in anxiety and sleep, respectively. Two months after the start of CBD treatment, 78.1% (32/41) and 56.1% (23/41) of patients reported improvement in anxiety and sleep, respectively, compared with the prior monthly visit; again, 19.5% (8/41) and 26.8% (11/41), respectively, reported worsening problems as compared with the prior month.

These results demonstrated a more sustained response to anxiety than for sleep over time. Patient records displayed a larger decrease in anxiety scores than in sleep scores. The sleep scores demonstrated mild improvement. The anxiety scores decreased within the first month and then remained decreased during the study duration.

CBD was well tolerated, with few patients reporting side effects. Two patients discontinued treatment within the first week because of fatigue. Three patients noted mild sedation initially that appeared to abate in the first few weeks. One patient with a developmental disorder (aged 21 years) had to be taken off the CBD regimen because of increased sexually inappropriate behavior. The CBD was held, and the behavior disappeared. The behavior reappeared on redosing 2 weeks later, and the CBD regimen was formally discontinued. The treating psychiatrist thought this was related to disinhibition because the patient’s anxiety responded dramatically. One patient noted dry eyes. Reasons for patients not following-up at later assessment points are largely unknown but are probably because of standard attrition experienced in usual clinical practice. There was no evidence to suggest patients discontinued care because of tolerability concerns. The attrition rates were similar in nature and size to those found in routinely scheduled visits in this clinic.

The treatment with CBD was in general well accepted, as judged by the clinicians’ and patients’ responses. Four patients declined CBD treatment because of religious or ethical concerns about the relation to cannabis. Nearly all patients easily provided informed consent once the nature of the treatment was explained. Most patients appreciated the opportunity to try something natural and avoid further or initial psychiatric medication use.


In an outpatient psychiatric population, sleep scores displayed no sustained improvements during the 3-month study. Anxiety scores decreased fairly rapidly, and this decrease was sustained during the study period. These results are consistent with the existing preclinical and clinical data on CBD. CBD was well accepted and well tolerated in our patients. Side effects were minimal (mainly fatigue) and may be related to dosing.

The doses used in this study (25 mg/d to 175 mg/d) were much lower than those reported in some of the clinical literature (300 mg/d to 600 mg/d) 12-14,17 for 2 reasons. The first is that in our experience lower doses appear to elicit an adequate clinical response. Second, the current retail cost of CBD would make the use of 600 mg/d cost prohibitive.

Study Limitations

These results must be interpreted cautiously because this was a naturalistic study, all patients were receiving open-label treatment, and there was no comparison group. Concurrent psychiatric medications were employed as in routine clinical care. This is both a limitation and strength, as very few publications exist in this population. Other researchers have noted that the large societal notoriety about cannabis and medical marijuana probably contributes to a larger-than-normal placebo effect. 20 Any study that explores efficacy in this therapy probably will struggle with a potentially inflated placebo effect that will make these determinations more difficult. Likewise, the clinical population in this case series is skewed younger than typical for our clinic, and future studies could explore the possible selection bias inherent in this treatment option. Most patients were also taking psychiatric medications and receiving other mental health services, such as counseling, which limits the ability to make any causal links to CBD treatment. Clinical attrition is evident in the dataset. The reason for this might be related to CBD ingestion or not, so the overall component remains unclear. Furthermore, patients at our clinic often express a desire to reduce or to avoid use of psychiatric medications, which may contribute to an enhanced placebo effect or additional bias. The length of clinical monitoring may help to decrease this concern. However, the clinical data in this analysis show a trend toward clinically significant relief of anxiety upon the start of CBD treatment.

Legality of Cannabidiol

The legality of CBD is not clear. Like the issues surrounding the legality of cannabis in general, CBD presents the clinician with a confusing state vs federal legal quandary, and this keeps the issue in question. CBD is legal in the 33 states that have legalized medical or recreational use of marijuana and in 17 other states that have legalized some form of CBD, according to the National Organization for the Reform of Marijuana Laws (NORML). 21 But like marijuana, it is still not legal at the federal level. The federal government has announced that it is not focused on this compound in terms of enforcement or interdiction. 22 However, CBD is interpreted by the Drug Enforcement Administration, Food and Drug Administration, and Congress to be a Schedule I substance, and therefore it is illegal in all 50 states. 23 Pragmatically, CBD is widely available on the Internet, with sales expected to reach $1 billion by 2020. Pending federal legislation to redefine the legal status of cannabis would clarify this complex issue. Canada’s move to legalize cannabis in October 2018 further highlights the need for a speedy resolution to this question. 24


Formal studies on efficacy and dose finding are much needed. Some urgency exists, given the explosion of lay interest in this topic and the rush to market these compounds. Current understanding of the physiology and neurologic pathways points to a benefit with anxiety-related issues. The results of our clinical report support the existing scientific evidence. In our study, we saw no evidence of a safety issue that would limit future studies. In this evaluation, CBD appears to be better tolerated than routine psychiatric medications. Furthermore, CBD displays promise as a tool for reducing anxiety in clinical populations, but given the open-label and nonrandomized nature of this large case series, all results must be interpreted very cautiously. Randomized and controlled trials are needed to provide definitive clinical guidance.

Disclosure Statement

Dr Shannon has published several professional books on integrative mental health. Dr Shannon is a Principal Investigator for a Phase 3 study of 3,4-methylenedioxy-methamphetamine (MDMA)-assisted psychotherapy for severe posttraumatic stress disorder and receives compensation for his clinical work from the Multidisciplinary Association for Psychedelic Studies, Santa Cruz, CA. The other authors have no conflicts of interests to disclose.


CV Sciences Inc, Las Vegas, NV, provided cannabidiol products for the study. CV Sciences was not involved in the data collection, data interpretation, preparation of the report, or decision to submit the report for publication. No other financial support was provided. The authors would like to express their deep appreciation to the staff and clinicians at Wholeness Center for their professionalism.

Kathleen Louden, ELS, of Louden Health Communications provided editorial assistance.

How to Cite this Article

Shannon S, Lewis N, Lee H, Hughes S. Cannabidiol in anxiety and sleep: A large case series. Perm J 2019;23:18-041. DOI: https://doi.org/10.7812/TPP/18-041

Author Affiliations

1 Department of Psychiatry, University of Colorado, Denver

2 Department of Naturopathic Medicine, Wholeness Center, Fort Collins, CO

3 North Range Behavioral Health, Greeley, CO

4 School of Social Work, Colorado State University College of Health and Human Sciences, Fort Collins

Anxiety Relief Without The High? New Studies On CBD, A Cannabis Extract

As more states legalize marijuana, there’s growing interest in a cannabis extract — cannabidiol, also known as CBD.

It’s marketed as a compound that can help relieve anxiety — and, perhaps, help ease aches and pains, too.

Part of the appeal, at least for people who don’t want to get high, is that CBD doesn’t have the same mind-altering effects as marijuana, since it does not contain THC, the psychoactive component of the plant.

“My customers are buying CBD [for] stress relief,” says Richard Ferry, the retail manager of Home Grown Apothecary in Portland, Ore., where recreational marijuana use is legal under state law, with some restrictions.

Another rationale Ferry’s heard from clients about their CBD use: “Their mother-in-law is in town, and they just want to chill out!”

“CBD has gotten a lot of buzz,” Ferry says, as he displays an array of CBD products, including capsules and bottles of liquid CBD oil that users dispense under the tongue with a dropper.

By one estimate , the CBD industry has doubled in size over the last two years, and is now worth $200 million. But with this popularity the hype may have gotten ahead of the science.

“There’s a lot of confusion about how it [CBD] works and what it does exactly,” Ferry says.

Researchers now are trying to nail down CBD’s effects.

“I think there’s good evidence to suggest that CBD could be an effective treatment of anxiety and addiction” and other disorders, says Dr. Esther Blessing, a psychiatrist and researcher at New York University. “But we need clinical trials to find out.”

So far, evidence of the substance’s anti-anxiety effect comes from animal research and from very small, short-term human studies that suggest CBD exhibits anti-inflammatory and anti-anxiety properties.

These preliminary findings piqued Blessing’s interest. For instance, she points to a 2011 study of a few dozen people, some of whom had social anxiety disorder, who were asked to speak in front of a large audience. Researchers compared anxiety levels in people after they took CBD, compared to those who got the placebo or nothing at all. (The participants didn’t know if they’d been given the drug or the placebo.)

And what did the scientists find? “People who took CBD reported significantly less anxiety” compared to those who got the placebo, Blessing says. “It’s really interesting.”

Now, with funding from the National Institutes of Health, Blessing and group of collaborators are about to begin a clinical trial to test whether CBD can help people with post-traumatic stress disorder who also have moderate or severe alcohol use disorder.

During the study, 50 participants with PTSD coexisting with alcohol use disorder will be given either 400 milligrams of CBD daily, or a placebo. The goal is to see if the participants who take CBD end up drinking less and whether this leads to an improvement in PTSD symptoms. The participants will be given a pharmaceutical-grade CBD, which is more reliable in strength and purity than the supplements that are currently available for sale to the public.

Another Phase 2 clinical trial (to test efficacy and side effects) is exploring whether CBD might help prevent relapse in opioid abusers by reducing craving for the drug. The study’s led by Yasmin Hurd, a neuroscientist who directs the Addiction Institute at the Mount Sinai School of Medicine.

Hurd has been trying to rally other top scientists to study CBD’s effects and potential benefits in the treatment of substance abuse.

It may seem counterintuitive that a component of marijuana could be useful in treating addiction to another drug. But Blessing says using CBD is very different from using marijuana. Though CBD is extracted from cannabis, it does not lead to altered perception and cognition.

“Drugs can be non-psychoactive and still have an effect on the brain,” Blessing says. “CBD does have an effect on the brain, but it seems to affect the brain in possibly medicinal ways.”

Results from Blessing study are a few years off. But in the meantime, just last week, a panel of advisors to the Food and Drug Administration recommended approval of the first pharmaceutical grade CBD, called Epidiolex, to treat severe seizure disorders in children. This could open the door to more research to approve its use in other disorders.

Dr. Robert Carson is a pediatric neurologist at Vanderbilt University who has evaluated the effectiveness of CBD supplements in kids with seizures. He says the supplements can be beneficial for these children. However, he says, if the FDA follows its advisory panel’s advice and approves a pharmaceutical-grade CBD drug, that would open up a new treatment option by delivering a high-quality, consistent dose of CBD.

“One of the main caveats I tell my patients who use a CBD supplement is that we cannot guarantee what’s in it,” Carson explains. “We can’t guarantee the consistency.”

Supplements aren’t regulated as strictly as pharmaceuticals, and can vary widely from bottle to bottle or brand to brand.

And there’s another issue would-be users face: Though CBD supplements are widely available for sale, a legal murkiness surrounds marijuana extracts.

Even if you live in a state where marijuana use is legal, the federal Drug Enforcement Administration still classifies the CBD extract as a Schedule 1 substance — the DEA’s most restricted category. According to the agency, “Schedule I drugs, substances or chemicals are defined as drugs with no currently accepted medical use and a high potential for abuse.”

Proponents of CBD’s use in treating medical conditions and ailments hope the findings of studies now underway will help change that thinking about its legal classification — and its potential benefits.

7 Best CBD Oil for Anxiety

For many people, anxiety may seem like any other mental health issue. However, in reality, it is one of the most difficult conditions to live with. Anxiety, if left untreated, may hinder one’s life, causing them so much trauma in their day-to-day life. In the US alone, about 18% of the population suffers from anxiety disorders.

Apart from how difficult it is to live with untreated anxiety, another ravaging issue is the lack of prescription medications that work effectively. However, over the recent years, many people have found CBD oil for anxiety to be a working solution. Some HealthCanal’s articles have already shown that CBD oils for anxiety do work.

If you are suffering from anxiety and depression, and are tired of trying different types of conventional medications, you should consider using CBD oils for treating your anxiety disorder. To help you further, this article discusses some of the best CBD oils for anxiety along with how to take CBD oils for anxiety.

Editor’s Choice


  • Huge product catalog
  • 100% organic products
  • Free shipping
  • Third-party lab tests

Best CBD Oil for Anxiety – 2021 Top 7 Brands

    – Editor’s Choice – Best Value – Best for Beginners

1. CBDfx – Editor’s Choice

  • Wide range of products
  • 100% organic and non-GMO
  • Compliant with cGMP guidelines
  • 3rd party lab testing
  • A+ BBB rating
  • Free shipping
  • Inexpensive pricing
  • Confusing website design
  • Doesn’t ship out of the USA

CBDfx was founded back in 2014, and ever since then, they have focused on manufacturing and selling high-quality CBD products to the masses. Even though it started as a small CBD company in San Fernando Valley, within no time, they have grown to be one of the top CBD sellers currently. CBDfx focuses on selling premium quality full-spectrum CBD products.

CBDfx sources its hemp from California. They claim that their hemp is 100% organic, grown without using any kind of pesticides or GMOs. Moreover, this company uses CO2 extraction, which helps in obtaining high-quality and potent output. As a result of this extraction method, their CBD oil is solvent-free. Also, their manufacturing facilities comply with cGMP guidelines as well.

Not only does CBDfx uses high-quality organic hemp, but they also make sure that their products undergo rigorous third-party lab testing as well. Anyone on the internet can easily access these lab testing results on their website. These tests look for the presence of any pesticides, contaminants, and toxins. They put their products under these tests to showcase the quality of their products, which also helps customers to go ahead without any hesitations.

CBDfx specializes in not only selling premium quality CBD products, but they also offer a wide variety of products as well. One can find many types of CBD products including topicals, salts, bathing bombs, tinctures, drinks, salts, creams, and even pet treats. Moreover, they ship products very quickly and their customer support is helpful and fast.

2. Spruce CBD

  • 100% organic products free of pesticides, GMOs
  • Moonshine extraction method
  • 3rd party lab tests
  • Offers sleep-inducing CBD products
  • Lack of flavor options
  • No free shipping

Spruce CBD has quite a popular reputation for their high-potent CBD products. Even though it started in 2018, the company has built a strong and positive reputation, thanks to their superior line of CBD products. Moreover, they have garnered tons of positive reviews and ratings across the internet. Their quality products, premium extraction methods, and excellent customer support system has helped them grow further and faster.

Spruce CBD owns two family farms in North Carolina and Kentucky. They source their hemp from these farms that they manage. Their hemp is grown without the usage of harmful chemicals, pesticides, or GMOs. By doing so, they ensure that their hemp is of very high quality, which helps them make premium CBD products.

Also, Spruce CBD uses one of the best extraction methods, “Moonshine”, where they use ethanol to extract, rather than the traditional CO2 mechanism. Many experts believe that the Moonshine extraction method is superior to the CO2 method.

They not only use organic hemp, but they also make sure that their final products are tested thoroughly by 3rd party labs. And, they also make the lab test results available to the public. You can simply visit their website to access these lab test results. These 3rd party lab tests look for the presence of any harmful or contaminating substances such as pesticides, toxins, GMOs, or heavy metals.

Spruce CBD has a decent range of products that span across CBD oils, salves, and creams. However, they also offer CBD products that are sleep-inducing. This makes them one of the best sellers that offer products to anyone who is suffering from sleep disorders such as insomnia.

The Peninsula Daily News and Seattle Weekly websites also provide information for those just getting started with CBD. They also have blogs and articles on CBD for anxiety that you may find helpful.

3. CBD Pure

  • US-grown hemp
  • CO2 extraction method
  • 3rd party lab tests
  • Compliant with GMP guidelines
  • 100% organic products
  • 90-day money-back guarantee
  • Only 4 product categories
  • No flavor options

CBDPure is a Washington-based CBD company that offers a lot of high-quality CBD products. The company is very well-known for their customer-centric business model. They currently sell only four categories of CBD products, but they are of superior quality. Their meticulous business approach coupled with the quality of their products has earned them an A + rating on BBB.

CBDPure sources their hemp from farms that are based in Washington and Colorado. Their hemp is grown organically, without ever using pesticides, insecticides, and GMOs. They use the CO2 extraction method, which is a great sign. Furthermore, they use full-spectrum CBD hemp seed oil as the carrier oil. By doing so, they ensure that their full-spectrum CBD products are of top quality.

CBDPure also puts their products through multiple 3rd party tests. Some of these tests include Cannabinoid Profiling, Microbiological Screening, Pesticide Testing, Residual Solvent Testing, and Heavy Metal Testing. Through these tests, they ensure that their products do not contain any contaminants, pesticides, toxins, or heavy metals. You can access these test results right on their website.

This brand currently offers four categories of CBD products. You can buy CBD oils, Softgels, Creams, and CBD for pets. Their CBD creams are especially popular among customers who suffer from joint and muscle pains. CBDPure is so confident about the purity and potency of their products, they even offer a 90-day money-back policy. Finally, their customer support is also excellent, as they are available to help you 24/7.

4. Joy Organics

  • US-grown hemp
  • CO2 extraction method
  • USDA-certified products
  • 30-day money-back guarantee
  • Pesticide-free products
  • Free shipping on all orders above $50
  • Pricey products
  • Clumsy website

Started in 2018, Joy Organics has been rapidly growing to be one of the highly popular CBD retailers in the industry. It all started when the founder, Joy Smith herself began using CBD for her sleep disorder. When it worked wonders for herself, she kickstarted a mission to manufacture and sell high-quality broad-spectrum CBD products to the people. Ever since then, Joy Organics has been evolving as a great CBD brand.

Joy Organics are currently not in the business of growing their own hemp. However, they get their hemp from different farms located in Oregon, Montana, and Colorado. All these farms follow the stringent guidelines of GMP to ensure the quality of hemp. The hemp is grown in the absence of pesticides, GMOs, and insecticides, and any other contaminants. Moreover, all the broad spectrum CBD products of Joy Organics are USDA-certified.

Joy Organics uses the CO2 extraction method, which is considered one of the best in the industry. Furthermore, this company also gets their products tested by 3rd party labs. These tests are conducted to make sure that the products do not contain any types of contaminants, pesticides, heavy metals, and other forms of toxins. The results of these tests are available for everyone to access on their website.

This CBD oil brand offers free shipping on any order that exceeds $50. They also offer a 30-day money-back guarantee on their products. By the way, Joy Organics is a member of the Board of Directors for the US Hemp Roundtable, a highly respected organization in the industry.

5. Royal CBD

  • Hemp source – California
  • Verified by third party testing
  • Compliant with GMP guidelines
  • Pesticide-free and GMO-free
  • Several flavor options
  • Free shipping
  • 30-day money-back guarantee
  • Not many oil strength options
  • Confusing website layout

For those of you who are looking to purchase full-spectrum CBD oil and other CBD products, Royal CBD is an excellent choice. This California-based company is very well-known for its consistency and transparency in delivering top-notch CBD products. Ever since its inception in 2018, Royal CBD has been successful in manufacturing and selling safe and potent products.

Royal CBD sources their hemp from farms based in California. They claim that their farming methods are truly organic, without the usage of pesticides or GMOs. They use the CO2 extraction method to make sure that the output does not contain any form of impurities or contaminants such as heavy metals, pesticides, bacteria, or insecticides.

Apart from that, their products are sent to 3rd party labs for rigorous testing. These tests help them determine whether their products are free of pesticides, GMOs, heavy metals, and other forms of toxins. Any user can access these test results on their website. Moreover, their products contain less than 0.3 THC, which makes them safe and legal.

Royal CBD is famous for their extensive product catalog. They sell a wide range of products such as CBD oils, capsules, CBD gummies, honey sticks, and topicals. Moreover, you can also buy CBD for pets as well. Also, their CBD oils come in different flavors such as berry, vanilla, and mint.

This brand not only sells quality products, but they also sell them at affordable prices. Moreover, they offer a 30-day money-back guarantee too. Furthermore, they also offer free shipping on all orders as well.

6. Penguin CBD

  • THC-free products
  • American-grown hemp
  • 3rd party lab tests
  • Shipping is free
  • Many flavor options
  • Excellent customer service
  • Not many high-potency options
  • Limited product categories

The journey of Penguin CBD started recently in 2019. However, they have made giant leaps ever since then, thanks to their high-quality product lineup and their transparent business model. The team at Penguin CBD consists of several CBD enthusiasts and scientists. It helped them grow rapidly while manufacturing products of excellent quality.

They grow their hemp in Oregon-based farms with a completely organic approach without pesticides and GMOs. They use the CO2 extraction method which helps them make THC-free products. Moreover, they use both broad-spectrum CBD oil extract and also CBD isolate as well.

Right now, they are offering four categories of CBD products which include CBD oil, gummies, capsules, and creams.

And, all of their products are rigorously tested by 3rd party labs to ensure quality, safety, and potency. Also, Penguin CBD doesn’t charge an extra fee for shipping. Moreover, they also offer a 30-day money-back guarantee too.

7. Sol CBD

  • Wide range of products
  • 3rd party lab tests
  • US-grown hemp
  • Education website
  • No shipping fee on orders above $75
  • 60-day money-back guarantee
  • Ships only within the USA
  • Some products are a bit expensive

Sol CBD was started by two life coaches who also happen to be a couple, Oksana and Larry Ostrovsky. Their passion for natural healing has led them towards CBD, which ultimately resulted in the birth of Sol CBD.

The company uses US-grown hemp, and they make sure that it is grown in a completely organic way without the involvement of GMOs and pesticides. Also, their products are vetted and verified by 3rd party lab tests. They use the CO2 extraction method for better quality and efficiency. They use MCT oil as their carrier oil.

Sol CBD has tons of product categories on offer. They sell a wide variety of CBD products such as CBD oil, capsules, tinctures, CBD for dogs and cats, CBD skincare products, and even CBD for sleep. They do not charge a shipping fee on orders above $75. Also, they offer a 60-day money-back guarantee too.

How To Use CBD Oil For Anxiety

If you are tired of trying different medications for your anxiety disorders, you must try using CBD oil to alleviate symptoms of anxiety. We all know how difficult it is to live with anxiety and depression. And, it gets worse without proper medication that helps with anxiety.

CBD oil is known to help with different mental health conditions such as Generalized Anxiety Disorder, Post Traumatic Stress Disorder, Social Anxiety Disorder, and many more.

If you are wondering how you can use CBD oil to manage anxiety disorders, you must first know how CBD interacts with your central nervous system and how it helps in treating anxiety depression. So, let us learn about it:

How Does CBD Oil Help With Anxiety and Depression?

CBD works by binding with the CB1 receptors of your Endocannabinoid system. This is the largest system in the human body, which plays a vital role in regulating your mood, while also playing a part in several functions of your body.

CBD also helps manage optimum Serotonin levels in your body. Serotonin is a hormone that regulates your mood. CBD oil also plays a crucial role in modulating a brain chemical called GABA, which tells your body when to relax and sleep. When your body gets enough rest, it becomes much easier to bring down your anxiety.

Here is How You Can Use CBD Oil For Anxiety

Before taking CBD to treat your anxiety, you need to know the effective ways of consuming a CBD product, especially if you are new to CBD. Also, try opting for full-spectrum CBD oil that contains all the fundamental cannabinoids and terpenes.

When you are trying to take CBD as a treatment for anxiety, you would want to go with the fast-acting consumption method. For that purpose, taking CBD oil orally is the way to go, as it helps your body absorb the CBD swiftly. Alternatively, you can also try vaping CBD for your anxiety and depression.

Apart from that, you also need to determine the appropriate dosage as well. To be honest, there is no perfect CBD dosage, as different people react to different doses of CBD.

Risks and Side Effects of CBD

CBD is usually a very safe substance, especially when taken by mouth. However, there are still a few risks and side effects of CBD you need to keep in mind. Dry mouth, drowsiness, low blood pressure, diarrhea, and decreased appetite are some of the commonly known side effects of CBD. However, do not worry, as the benefits of CBD far outweigh these side effects.

Also, keep an eye on the number of mg of CBD per day you are consuming. Overdose should be avoided at any cost. Also, if you are either pregnant or breastfeeding, try not to consume CBD. People with liver diseases and Parkinson’s disease should be careful while trying CBD.


CBD oil works very well for people with anxiety and depression. Also, there is quite an amount of research on CBD that proved the significance of CBD and its role in treating anxiety. However, before taking it, talk to your doctor for proper guidance on dosage.

Also, make sure that you also follow a healthy diet and lifestyle, since they also play a major role in managing your anxiety. Try meditating for a few minutes every day. All these practices will complement CBD in helping you manage your anxiety and other mental health issues.