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Can I Take Ibuprofen With CBD Oil? the Guide on Taking Both

Pain and inflammation can be a part of life for some people. If you struggle with pain often, you might take ibuprofen regularly. Recently many are turning to CBD oil as an additional form of pain relief. But can you take ibuprofen with CBD oil?

According to medical research, cannabinoids might offer significant ‘side benefits’ beyond treating chronic pain. So, we’re going to discuss whether you can take ibuprofen with CBD oil.

Can I take Ibuprofen with CBD oil? Providing you are not allergic to ibuprofen, it should be safe to take with CBD oil. There is always a potential risk of an allergic reaction, so proceed with caution and check with your doctor. There is no firm research recommending not to take cannabinoids such as CBD oil with ibuprofen.

First, let’s recap on what CBD oil is, then we’ll get into more of the details.

What is CBD oil?

CBD, a type of chemical known as a cannabinoid, is one of the hundreds of cannabinoids found in the cannabis plant.

It’s the main ingredient in hemp, which is one type of cannabis plant.

Marijuana, another type of cannabis plant, also contains CBD, but it also contains what is commonly known as THC (tetrahydrocannabinol), which is psychoactive and not used in CBD oil.

THC is responsible for providing individuals with that sense of euphoria or “high” feeling.

There are several common ways to take CBD oil. But if you are wondering whether you can combine CBD oil with over-the-counter pain relievers such as ibuprofen, let’s examine why you might take ibuprofen.

Why take ibuprofen?

  • Ibuprofen is an everyday painkiller for a range of aches and pains, including back pain, period pain, toothache. It also treats inflammation caused by strains, sprains, pain from arthritis, and other injuries.
    is a non-steroid, anti-inflammatory. Simply put, it reduces inflammation and pain in the body, and it can also be used to bring down a fever or temperature. Some common brand names of ibuprofen include Advil and Motrin.
  • Ibuprofen works by blocking the production of prostaglandins. Prostaglandins cause pain and swelling, or inflammation, and are substances that the body releases in response to illness and injury.
  • Ibuprofen’s painkilling effects begin soon after taking a dose.

Who might use CBD oil with ibuprofen?

CBD has been used for thousands of years as an alternative remedy to help with pain, inflammation, depression, and anxiety. Individuals suffering from the following conditions may be more likely to use CBD oil with ibuprofen.

  • Arthritis – Those dealing with arthritis may be looking for additional pain relief. Therefore, they may be more likely to combine CBD oil and ibuprofen to help deal with the symptoms.
  • Menstrual pain – Equally, sufferers from dysmenorrhea, which is the pain and discomfort felt during the menstrual period, may explore how the benefits of both CBD and ibuprofen may work together in reducing symptoms.
  • Anxiety and depression – Anxiety decreased within the first month of 57 patients involved in a recent CBD study. Although more research is recommended, this is promising regarding CBD oil’s ability to help relieve anxiety. Anxiety and stress have been linked to increased inflammatory markers. This can weaken the immune system, making you more susceptible to illness, leading to taking ibuprofen. Therefore, those dealing with anxiety and depression may be more likely to combine CBD oil with ibuprofen.
  • Dental pain – CBD oil can be applied or ingested for dealing with tooth pain. However, this often does not provide quick pain relief. So, patients will more than likely consider taking ibuprofen in addition to the CBD oil.

How do ibuprofen and CBD oil work?

  • CBD oil – the way CBD works is complex and is not yet as well understood as ibuprofen. It appears to offer pain relief by inhibiting the action of neurotransmitters. According to a 2018 publication in Frontiers of Pharmacology, CBD has an inhibitory effect on neurotransmitters and neuropeptides that are involved in the ‘activation of descending inhibitory pain pathways, along with the reduction of neural inflammation.’
  • Ibuprofen limits the number of enzymes produced by cyclooxygenase-2 abbreviated as COX-2. This results in decreased prostaglandin release when the body experiences injury, leading to lowered inflammation and pain.

As we can see, the main difference between CBD and ibuprofen is how they interact with pain response pathways.

How should I take ibuprofen with CBD oil?

Spacing out drug doses is a safer way to use both CBD and ibuprofen. The time at which you take both CBD and ibuprofen may influence how the two drugs interact.

For instance, depending on a drug’s dose, it has the potential to inhibit liver enzymes for a variable timeframe.

So, spacing doses out would assist liver enzymes in regaining sufficient function by the time a second drug is taken.

Currently, not much is known about how CBD could interact with other medications, including ibuprofen. More research needs to be done, but current research has shown that CBD poses inhibitory action on some enzymes that galvanize drug metabolism.

When examining CBD drug interactions, it seems that ibuprofen falls into the second of two categories: caution must be exercised when combining with CBD oil.

Is there any medication not safe to take with CBD oil?

According to some medical journals, as CBD is often used by different kinds of patients, often with complex conditions and treatment plans, it’s important to know any potential safety issues when combining CBD oil with prescription drugs.

Therefore, it is crucial that you consult your doctor if you are planning on combing CBD with any other medication.

Is CBD oil safe?

When combining CBD oil with ibuprofen, you should also ensure that it is safe to do so.

According to recent medical research, potential uses of CBD alone, or in combination with THC, include reducing pain and inflammation, both important qualities of Ibuprofen.

CBD may also be used for the following conditions:

  • Epilepsy
  • Cancer
  • Anxiety
  • Neurodegeneration
  • Multiple sclerosis,
  • Psychotic disorders
  • Depression

In terms of safety, using CBD alone is considered safe. Any side effects are generally mild. However, this does not consider possible drug interactions, which is why it is crucial that you consult your doctor beforehand.

Is CBD legal?

Purchasing CBD is federally legal as long as it doesn’t contain more than 0.3 percent THC. However, some state laws have put restrictions on buyers. For example, Virginians can only buy and possess CBD if they have a certification.

Closing thoughts

Combining drugs can often have varying effects for each individual, and it also largely depends on the state of your health. This is why seeking your doctor’s advice before proceeding is important so that the right course of action can be taken, and any drug usage or combination of drugs can be properly monitored.

If you’re having trouble affording any of your medications, enroll with us and see if you qualify to pay only $50 a month for each of your medications.

CBD Is A Safer Option Than Ibuprofen For Pain And Inflammation Relief

Ibuprofen and cannabidiol are both capable of treating pain and inflammation in the human body. However, ibuprofen’s long list of nasty side effects makes it a much more dangerous treatment option. By comparison, CBD is not only much safer to regularly consume, but can also help improve your general mental and physical well-being.

When it comes to pain and inflammation, most people rely on over-the-counter medicines like Advil and Motrin. But should they? Despite the public perception that these drugs are safe, many individuals experience complications or adverse effects that can lead to hospitalisation, or even death. As such, using naturally-derived alternatives is advised whenever possible.

One promising alternative is CBD, a cannabinoid derived from the cannabis plant. CBD has been clinically proven to reduce pain and eliminate inflammation, with minimal side effects. Moreover, CBD provides numerous other benefits that can improve your mental and physical health. Not only is it safer, it’s a more convenient alternative to over-the-counter painkillers like ibuprofen.


Ibuprofen is a synthetic compound that is widely used in anti-inflammatory and pain-killing drugs. It is the main ingredient in many over-the-counter non-steroidal anti-inflammatory drugs, or NSAIDs, like Advil and Motrin. Ibuprofen-based NSAIDs are some of the most accessible and commonly consumed drugs on the planet. This is largely because of NSAIDs’ wide range of uses. They are commonly used to treat pain, reduce inflammation and fever, eliminate headaches, and prevent blood clots, among other uses.


When the human body suffers from trauma or physical injury, compounds called prostanoids are produced by cyclooxygenase enzymes called COX-1 and COX-2. Prostanoids generated by COX-2 enzymes are responsible for regulating pain and inflammation. Ibuprofen works to constrain and inhibit these enzymes and the prostanoids that they produce. As a result, pain and inflammation are significantly reduced or eliminated altogether.

Ibuprofen is a non-selective COX inhibitor, meaning that it blocks both the COX-1 and COX-2 enzymes. This makes it suitable for a wider range of uses. However, it also results in more side effects when compared to selective COX inhibitors that only block one or the other.


Cannabidiol, otherwise known as CBD, is a cannabinoid found in the cannabis plant. It is a non-psychoactive cannabinoid that does not have mind-altering effects. It does, however, have plenty of medicinal value. Preclinical and clinical research have shown CBD to be effective in the treatment of a vast range of medical conditions, including inflammation and inflammation-related pain. CBD is very well-tolerated, even at high doses, and poses no risk of overdose. Cannabidiol can conveniently be consumed in a number of forms such as capsules, tinctures, e-liquids, or edibles.

CBD is commonly used to treat a variety of ailments including anxiety, depression, substance withdrawal, inflammation, arthritis, certain forms of epilepsy, skin conditions, physical pain, neurological pain, and cancer-related symptoms, among others.


At one point, researchers believed that CBD worked by interacting directly with CB1 and CB2 receptors in the body and brain. However, more recent research indicates that this is not true. Instead, CBD works through multiple processes.

CBD has been clinically shown to reduce inflammation by causing immune cells to cease their production of cytokines. Research has also shown that CBD has the ability to influence receptors responsible for pain modulation, thereby reducing pain. It does this by limiting the body’s absorption of anandamide, a compound associated with regulating pain. Through this process, CBD reduces both the amount of pain being felt and the underlying inflammation causing it.

Furthermore, CBD stimulates the body’s endocannabinoid system to help it better maintain the level of endogenous cannabinoids in the body. In turn, the endocannabinoid system is better able to perform its role in the regulation of things like mood, appetite, and sleep.


Ibuprofen and CBD are both suitable options for the treatment of pain and inflammation. However, they differ in certain key aspects that can affect your experience using them, and your overall health.


The most important difference between these two compounds are the side effects they produce. NSAIDs like ibuprofen have a nasty reputation for causing a plethora of adverse and unwanted side effects.

Serious side effects and complications from the use of NSAIDs are common, and can sometimes be severe. The broad spectrum of side effects caused by NSAIDs include ulcers, gastrointestinal bleeding, tinnitus, headaches, dizziness, liver problems, kidney problems, swelling of the legs, high blood pressure, stroke, heart attacks, and death. The risk of experiencing side effects from the use of NSAIDs is estimated to be as high as 25%.

By comparison, the risk of experiencing side effects from CBD is much lower. In addition, much larger quantities of CBD can be safely consumed in one day. A 2011 study found that huge daily doses of up to 1,500mg were well-tolerated by the human body. Because it is non-toxic, CBD is also a much safer choice for your kidneys and liver. When it comes to cardiovascular health, research has shown that, unlike ibuprofen, CBD will not affect your blood pressure, heart rate, or body temperature.

When CBD’s side effects are experienced, they are typically very mild. A 2017 study on the safety of CBD use found the most common side effects to be tiredness, diarrhoea, and changes in appetite or weight. All side effects ceased immediately after ingestion of CBD was stopped.


The regular use or overuse of NSAIDs has the potential to lead to hospitalisation or death. Most of ibuprofen’s adverse side effects are typically experienced after prolonged or regular use. As such, those who regularly need to medicate for pain or inflammation would be better off choosing cannabidiol. CBD is both a better short-term and long-term solution than ibuprofen since much more of it can be ingested in one day, and since its long-term side effects are mild in nature.


Another advantage of using CBD is how quickly its effects kick in. If taken orally, ibuprofen’s effects can typically be felt within 20 to 30 minutes. For certain types of long-term pain, ibuprofen requires up to 3 weeks of regular use to work properly. By comparison, if vaped, smoked, or consumed sublingually, CBD’s effects can be felt within minutes, if not seconds.


CBD provides you with many more flexible dosing options than over-the-counter NSAIDs. CBD can be consumed in the form of capsules, edibles, tinctures, oils, e-liquids, isolate powder, salves, and lotions. High-CBD marijuana strains can also be smoked or vaped to similar effect.


CBD has been quickly gaining popularity among athletes for its ability to improve both their workouts and their recovery. Because it is non-psychoactive, it can be conveniently used before and after workouts. Moreover, because side effects are so rare, it can be safely taken as part of a stack with other supplements. When taken before a workout, CBD can provide an energy boost and a calm sense of focus. When taken after a workout, CBD will immediately get to work relaxing your muscles and relieving pain, tension, and inflammation.

Many athletes find that when taking CBD, they are able to benefit from multiple effects at once. CBD’s clinically proven anxiolytic properties reduce anxiety, which in turn improves sleep. Furthermore, researchers have speculated that the neuroprotective qualities of CBD may actually help to protect the brain from concussion or other injury.


Research shows that CBD and THC both have antioxidant properties. A 1998 study found that the two cannabinoids were powerful neuroprotective antioxidants. Moreover, the study concluded that CBD may be a potential treatment for oxidative neurological disorders. Next time you use CBD for pain or inflammation, consider the potential improvement on your overall health as an added bonus.