cbd oil for ovarian cancer

Cbd oil for ovarian cancer

Published: 23:10 GMT, 3 September 2019 | Updated: 03:31 GMT, 4 September 2019

Doctors claim a woman has been virtually ‘cured’ her ovarian cancer – after shunning traditional treatment and taking CBD oil and apricot extract instead.

The ‘dramatic response’ has been documented by surgeons at the University of California, San Diego.

Most doctors warn against eschewing traditional treatments for alternative therapies, but are open to complementary alternative medicine, often referred to as CAM.

But after being diagnosed with a rare form of ovarian cancer that responds poorly to treatment, one 81-year-old woman elected to have surgery, but forego standard chemo.

Instead she started on a regimen of cannabidiol (CBD) and amygdaline, a bitter substance found in fruits that turns to a form of cyanide thought to kill cancer cells.

By November 2018, to the doctors’ amazement, the unnamed woman’s tumors had all but disappeared, they reported last month in the journal Gynecologic Oncology Reports.

For most patients with most cancers, it would be ill-advised to use alternative therapies in the place of standard treatment, but this unique scenario could provide unique insights into potentials for CBD in oncology.

A CT scan of the woman’s pelvis reveals the unidentified woman’s series of tumors after she’d had surgery, but before she’s started her experimental treatment regimen

Over the next year, while taking CBD and a toxic nut oil, the woman’s tumors shrunk considerably, raising questions about alternative treatments among her doctors

UNIQUE CIRCUMSTANCES MEANT CHEMO WAS UNLIKELY TO HELP

The woman went to see her GP in March 2017, initially suspecting a hernia.

By April 2017 she’d been diagnosed with ‘low grade serous ovarian cancer’, aka LGSOC, a relatively rare form of ovarian cancer that often doesn’t respond well to chemotherapy.

She had ‘multiple’ tumors, ranging from 7 mm to 7cm in size and referred to the UC San Diego School of Medicine.

But Dr Ramez Eskander says: ‘After extensive counseling, the patient declined all interventions due to concerns regarding quality of life and treatment toxicity.’

Instead she, ‘elected to pursue alternative therapy’ and started taking CBD oil – aka ‘cannabidiol’ – each evening, as well as ‘Laetrile’ or amygdalin tablets – which contain a compound found in the seeds of certain fruits, such as apricots, and thought by some to have cancer-fighting properties.

And what happened next stunned the medics.

SCANS SHOW REMARKABLE TUMOR SHRINKAGE IN A MATTER OF MONTHS

By July 2017, CT scans showed a decrease in the size of the tumors.

The scans were repeated in September and November of the same year, and ‘continued to show a dramatic reduction in her disease burden, with near complete resolution of all previously identified lesions’.

‘On her most recent interval assessment in December 2018 she continues to show a response to therapy,’ Dr Eskander says.

Surgeons also monitored the cancer through what’s known as ‘CA125’ blood tests, which are also common for patients in the UK.

A high level of CA125 in your blood could be a sign of ovarian cancer.

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At the start of the woman’s treatment journey, her CA125 score was almost 80. By November 2018, it had ‘normalized’ to around 10.

BOTH ALTERNATIVE COMPOUNDS HAVE SHOWN PROMISE – BUT HAVE NOT BEEN PROVEN

Dr Eskander adds: ‘In this case report, we present the case of a female patient who demonstrated disease response after declining standard therapy and taking a combination of Laetrile and CBD oil.

‘Previous clinical trials in humans have demonstrated no therapeutic effect in cancer patients taking Laetrile,’ he said.

In petri dish experiements, amygdalin has appeared to have some properties that could kill cancer cells, but that hasn’t proven to be the case in animal experiments – though there has been renewed interest in the compound in recent years.

‘However, basic science studies have identified cannabinoid receptors in ovarian cancer as potential therapeutic targets for cannabinoid use in treating malignancy,’ says Dr Eskander.

Lab and animal experiments have indeed shown some promise, but scientists caution that these aren’t enough o say that CBD has antitumor effects in humans.

However her improvements may be explained, the size of the woman’d tumors nose-dived after surgery and alternative therapy reaching ‘normalized’ levels in a matter of months, a graph of her tumor volume shows

‘This area remains under study, and this case highlights the importance of communication between physicians and their patients regarding use of alternative therapies.’

CBD oil is extracted from cannabis plants but contains only trace amounts of the high-giving chemical ‘tetrahydrocannabinol’, resulting in a legal product.

It’s sold in the UK and US as a super-food supplement and powerful antioxidant said to promote health and wellbeing.

Of course the case report is welcome news to the the CBD industry – which is worth $813 million in the US alone – and to UK CBD oil brand CBD Armour.

He says: ‘Until we have a wealth of thorough, robust and peer-reviewed scientific studies into CBD oil, it’s impossible for us to know definitively what health benefits it might have.

‘But what we do know for sure is that many of our customers report improvements to things such as pain relief, or for anxiety and sleep promotion.

While CBD oil is legal, Laetrile is mired in controversy and banned from being sold in the UK and US.

Laetrile contains cyanide, a poison and can cause serious side effects.

Surgery had rid the woman of some of her cancer, but the mysterious shrinking of her tumors thereafter suggest that the very experimental treatment might have helped her overcome the disease after sugery.

‘Cannabis is letting me live longer’

Michelle Kendall’s journey as a medical marijuana patient was “an accident” as she puts it, and it came after she went all the way through high school and college without ever coming into contact with cannabis.

“I’m from the era of (former US First Lady and anti-drug advocate) Nancy Reagan and I was very scared of this stuff,” she told The Cannigma in a phone interview. “I thought this was crazy but when you’re up against the wall you know you’ll try anything.”

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Kendall, a 47-year-old former biologist, has terminal ovarian cancer, and her cell type is high-Grade Serous Carcinoma, with BRCA1/2-, and P53+. She was diagnosed four years ago and in the time since, has gone through eighteen rounds of chemotherapy and two major surgeries.

“I’m pretty much out of treatment options at this point,” she said.

A recent five-week round of physician-guided cannabis therapy, which saw her taking 80mg of THC per day, “worked as well as any round of chemo I’ve had,” she said.

Kendall says she won’t do any more rounds of chemotherapy. “I’m now just going with the cannabis because I know cannabis is a better option,” she said, adding that she believes it helped shrink her tumor.

According to the American Cancer Society, “there have been some early clinical trials of cannabinoids for cancer in humans and more studies are planned. While the studies so far have shown that cannabinoids can be safe in treating cancer, they do not show that they help cure the disease.”

Tests carried out on rodents and in labs have found that THC and other cannabinoids can potentially have a positive effect on tumor size. One study on rodents from 1996 found that THC could have a protective effect on tumor development, while a 2003 study on mice found that cannabinoid-treatment could induce “a considerable growth inhibition of malignant tumors” and increase cell death in tumors. More recently, a study published in 2014 found that direct targeting of cannabinoid receptors in cancer cells “via appropriate doses of THC may be an effective approach to reducing tumor growth.”

Also, researchers from the Israel Institute of Technology have said that they have found that “specific cannabis extracts impaired the survival and proliferation of cancer cell lines as well as induced apoptosis (cancer cell death).” The tests were not carried out on live animal or human models at the time of that study’s publication.

Kendall has tracked her treatment and tumor growth herself at her home in Santa Barbara over the past year using blood tests to track her CA-125 levels, which are sometimes used to indicate the progression of some ovarian cancers, and then seeing how those levels correspond to her THC regiment.

Her current regimen consists of a 5mg THC gummy in the morning, another one at 3pm, and then a 15-20 mg THC tincture dosage at bedtime.

She said that it does have some side effects, but describes THC as “incredibly forgiving.”

“I certainly have had short-term memory issues, and it’s been more difficult to focus. It’s easier to get lost in my head than it used to be,” she said. “Those are issues that are easy to deal with. I sleep great and I have some days where I feel high before I go to bed but it’s nothing worse than a big glass of wine.”

Kendall captured her experience with medical cannabis in the short documentary “Schedule 1,” which she released online this year on April 20 (“my new favorite holiday,” as she puts it).

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The film opens with Kendall’s voice narrating “my name is Michelle and I have a crazy story to share. I have incurable cancer and I’m treating myself with a substance that’s been banned around the world for 80 years.”

In the movie, she interviews her neighbor, retired general practitioner and cannabinoid researcher William Black, who was the first to recommend to her cannabis as a way to help relieve her anxiety and help her sleep. He also gave her some of his homemade THC chocolates, which was her introduction to cannabis as medicine.

In the documentary, which was selected for the 2020 Los Angeles Shorts Film Festival, she describes her own tracking of her disease progression, saying “I’m just going to have to do my own science because I’m not going to have time to wait for real clinical trials.”

Kendall is careful to note that cannabis “is not a magic bullet,” and when asked if she would recommend other cancer patients try cannabis as a treatment, she replied “it’s not a magic cure all.”

“There’s very complex biochemistry going on and if you have the type of cancer that is very easily treated on a regimen that’s already been documented I would say please don’t abandon the traditional treatment,” Kendall said.

She also said that cannabis treatment should be done with the guidance of a trained physician.

“There is nothing in the pharmacopoeia that is going to save me,” Kendall said, adding that cannabis “may not be curative but I know that’s allowed me to live longer.”

Ovarian cancer and CBD oil

Cbd is only any good as a pain killer, some people have been using it for years me included..

As far as any body knows no tests have been done to check on anything else. Thares also a risk of different side effects maybe some of them bad. Check with oncologist before trying.

Good luck with your treatment and best wishes for the future.

1474 posts since

Ovarian cancer and CBD oil

I have no personal experience but I know that anyone who is thinking of trying it MUST check with their consultant first. This is to ensure it doesn’t contradict any treatment that the patient is on.

Ovarian cancer and CBD oil

Hi Paul, Are you meaning to treat the cancer, or manage symptoms? Some people certainly swear by CBD for pain or chemotherapy induced nausea. Others I’ve spoken to don’t find it effective at all. It also has a huge variability in what dose can be effective and needs to be slowly increased over a few weeks. There are a few potential interactions with other medications so you would need to discuss with treating oncologist.

My wife is using it for nausea management after still having nausea with domperidone, ondansetron, haloperidol and olanzapine. It hasn’t been a magic bullet but has helped to some degree.