cbd oil for leg ulcers

CBD for Venous Leg Ulcers: Complete Wound Closure in 81% Chronic Cases

A new study shows that a combination of CBD, terpenes, and flavonoids improves the results of compression therapy in venous leg ulcers. With the application of the topical solution containing molecules naturally present in cannabis, the wounds rapidly healed in patients with chronic conditions. The scientists believe in the efficiency of CBD for venous leg ulcers as a promising novel supportive therapy.

Venous leg ulcers are a chronic problem in many countries, especially in Northern Europe and the US. The overall prevalence of this condition is 1% rising to 3% in patients over 65 years of age. The venous leg ulcers are formed in the skin over the ankles and often are painful. Their treatment includes standardized care, which relies on a reliable diagnosis, compression, and local wound care. The healing of these wounds is variable, with common recurrence.

A recent analysis of 1323 patients reported that the proportion of patients who achieved complete closure using compression therapy at three and six months was 42.2% and 48.6%, respectively.

A new study published in May 2021 in Experimental Dermatology shows that a combination of cannabidiol, terpenes, and flavonoids leads to rapid wound closure of previously non-healing venous leg ulcers among elderly and highly complex patients.

This prospective open-label cohort trial recruited 14 patients with 16 chronic and non-healing leg ulcers referred to a regional consultative wound management clinic in Toronto, Canada.

The median age of the patients was 75.8 years, all with chronic wounds. One 81-year old patient with a surgically fused ankle was affected by his wound for 12.2 years. More than half of the patients had moderate to severe lipodermatosclerosis, edema, and peripheral arterial disease, all of which are significant factors against wound closure.

All patients had venous leg ulcers for longer than six months that failed to close despite at least four weeks of compression therapy. All patients underwent duplex venous dopplers that confirmed the presence of venous incompetency, and wound biopsies were carried out to rule out neoplasm, vasculitis, and rare vasculopathy. All patients provided informed consent for treatment using cannabis-based medicines – VS-12 and VS-14.

The cannabis-based medicines in this trial were composed of mixtures of cannabinoids, terpenes, and flavonoids applied topically to the wound beds and peri-wound tissues. VS-12 and VS-14 were chemically equivalent but compounded in separate vehicles. Formula VS-12, applied to wound bed consisted of CBD 3.8 mg/ml, THC <1 mg/ml, Quercetin 31.3 mg/ml, Diosmin 25.3 mg/ml, Hesperidin 2.5 mg/ml and Beta-Caryophyllene 152.7 mg/ml in the base carrier containing Hyaluronic acid + Aloe Vera Gel (1/1 v/v). Formula VS-14, applied to peri-wound, consisted of the same components but in liposomal base.

CBD for venous leg ulcers: The treatment

Great results obtained in this study on CBD for venous leg ulcers resulted with the following methodology:

Treatments were carried out every second day and continued until complete wound closure,
defined as the wound bed being 100% epithelialized. On their initial visits, all patients’ degrees of global medical complexity was calculated using both the M3 multimorbidity index tool and the Palliative Performance Scale score (PPS). Qualitative clinical assessments of their degrees of lipodermatosclerosis, edema, and peripheral arterial disease were also scored and documented. Following gentle cleansing with sterile normal saline, each patient underwent application of evenly applied thin layers of VS-12 to the wound beds, and VS-14 to a 4-6 cm radial cuff of peri-wound integument every second day. Tissues were then covered with one layer each of Jelonet and Mesorb. This was followed by the application of inelastic compression bandages, chosen based upon patient preferences, using a spiral technique, between the level of the metatarsal phalangeal joints and the infra-popliteal space.

Two-dimensional wound measurements, namely, widest width and longest length, were documented at each visit after debridement was carried out. Given the irregular and eclectic wound bed contours, the wound area calculations were approximated by matching them to various geometric shapes and applying their respective mathematical formulae. Data was also fitted to a linear regression model to report the general trend and the estimated time to complete wound closure. The observed time to complete wound closure, defined as the number of days since treatment onset to observe complete wound closure since the start of treatment, was calculated. The wound area data points were also fitted using a least-squares linear regression model. The slope was extracted to report both the absolute (cm² per 30 days) and relative (% of original wound area per 30 days) rates of wound healing. The estimated time to achieve wound healing, defined as the number of days since treatment onset for the linear fit line to reach zero was reported.

Rapid wound closure in 34 days

Complete wound closure, defined as being fully epithelialized, was achieved among 11 patients (79%) and 13 wounds (81%) within a median of 34 days. The three remaining patients were unavailable for follow-up because one of them moved out of the country, and two died of unrelated reasons. However, those three wounds also demonstrated progressive healing when last seen. There were no significant adverse reactions in any patients.

These positive outcomes are the result of potentiation and synergy between cannabinoids, terpenes, and flavonoids, the scientists conclude.

The rapid wound closure of previously non-healing venous leg ulcers among elderly and highly complex patients suggests that topical cannabis-based medicines may become effective adjuvants in conjunction with compression therapy. It may also indicate that they may have an even broader role within the skin and wound management.

Cbd oil for leg ulcers

Venous leg ulcers – also called “open leg” – are deep, poorly healing wounds on the lower leg. Older, chronically ill patients suffer most often from this disease. An additional therapy with topical cannabis-based medicines accelerates wound healing. A Canadian research team recently found this out in an open study. One reason for this is the cannabinoids tetrahydrocannabinol (THC) and cannabidiol (CBD), as well as flavonoids and terpenes, which are contained in the cannabis plant.

Why do patients get venous leg ulcers?

The disease occurs as a result of circulatory problems in the legs. Most often due to weakness of the leg veins. Here, the return transport of the blood to the heart is impaired. The ulcers are usually treated with compression bandages, which support the return transport of the blood. In addition, medicines applied externally to the skin, so-called topical medicines, are used to heal the wounds.

With these methods, however, the chances of complete wound healing are only 50 to 75 percent after six months of optimal treatment. The chance of the ulcers coming back within a year is 40 to 70 per cent. For this reason, patients must wear compression stockings as a preventive measure.

Some risk factors for venous leg ulcers are:

  • Chronic venous insufficiency (weakness of the leg veins)
  • Peripheral arterial occlusive disease
  • Reduced walking ability
  • Advanced age
  • Obesity
  • diabetes mellitus
  • High blood pressure

Complete wound closure in 79% of patients

The open study at a wound centre in Toronto involved 14 patients with a total of 16 wounds. The usual therapies such as compression stockings had not helped the study participants and the ulcers were on average older than six months. One patient had even been suffering from a wound for more than twelve years. The average age of the participants was 75.8 years and they had more complex concomitant diseases. In addition, most patients had risk factors for reduced wound healing such as oedema (water retention) and peripheral arterial circulatory problems.

Treatment was with compression bandages and topical cannabis-based medicines. The cannabis preparation was applied to the wounds and the adjacent area every two days by the patients themselves. The cannabis formulation contained the cannabinoids THC and CBD, the flavonoids quercetin, diosmin and hesperdin, and the terpene beta-caryophyllene.

The outcome of the treatment was very encouraging. Complete wound closure was observed in 11 patients (79 %) and 13 ulcers (81 %) after an average of 34 days of treatment. In the other subjects, advanced wound healing was observed. Side effects did not occur.

Interaction of cannabinoids, flavonoids and terpenes

The endocannabinoid system (ECS) plays an important role in wound healing. The anti-inflammatory effects of THC and CBD are mediated via the CB1 and CB2 receptors. These receptors are abundant in our skin. Cannabinoids also lead to a widening of the blood vessels, which improves tissue perfusion as well as oxygen supply.

The terpene beta-caryophyllene binds to CB2 receptors and also has an anti-inflammatory effect. The flavonoid quercetin can also accelerate wound healing and diosmin, hesperidin as well as flavonoids strengthen the veins.

Simple and safe wound treatment with topical cannabis medicines

The study shows that cannabis preparations for external use accelerate wound healing in venous leg ulcers. Even in wounds where conventional therapies no longer help properly, healing was accelerated significantly. Another advantage is the uncomplicated application, which patients can carry out independently at home. In the future, there will be further studies investigating topical cannabis preparations against other types of wounds.

Source:

Maida V, Shi RB, Fazzari FGT, Zomparelli L. Topical Cannabis-Based Medicines – A Novel Adjuvant Treatment for Venous Leg Ulcers: An Open-Label Trial. Exp Dermatol. 2021 May 19. doi: 10.1111/exd.14395. Epub ahead of print. PMID: 34013652.