cbd oil for interstitial cystitis pain

Cannabis Research for Interstitial Cystitis (Painful Bladder Syndrome)


Interstitial Cystitis (IC), also called bladder pain syndrome, is a chronic, or long-lasting, condition that causes painful urinary symptoms. Symptoms of IC may be different from person to person.
For example, some people feel mild discomfort, pressure, or tenderness in the pelvic area. Other people may have intense pain in the bladder or struggle with urinary urgency, the sudden need to urinate, or frequency, the need to urinate more often.

Health care professionals diagnose Interstitial Cystitis (IC) by ruling out other conditions with similar symptoms.

Researchers don’t know the exact cause of IC. Some researchers believe Interstitial Cystitis (IC) may result from conditions that cause inflammation in various organs and parts of the body.

Severe IC symptoms can affect your quality of life. You may feel like you can’t exercise or leave your home because you have to use the bathroom too often, or perhaps your relationship is suffering because sex is painful. — National Institute of Diabetes and Digestive and Kidney Diseases

Below is a Library of Cannabis Research Studies for Interstitial Cystitis (IC).

Functional Role of Cannabinoid Receptors in Urinary Bladder

A Case of Cannabinoid Rotation in a Young Woman with Chronic Cystitis

Because of the satisfactory effect on pain , we attempted rotation of the cannabinoid. Therapy was switched to dronabinol (Marinol, Banner Gelatin Products Corp., Chatsworth, CA) 2.5 mg orally daily. Pain perception was further reduced (VAS 30) and side effects were greatly diminished. The patient only reported a `strange feeling`. She was able to sleep well and was not impeded in daily life. When the dronabinol dosage was reduced to 2.5 mg every second day, pain perception remained low and side effects almost vanished. The patient was able to again take up her profession.

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This clinical picture has remained stable for six month. This case represents the first report of a successful cannabinoid rotation in an effort to maintain analgesia while reducing side effects. Whereas the analgesic effect of cannabis is still controversial, a multitude of case studies report a high efficiency of this substance for pain therapy. Following other ineffectual medications and therapies, cannabinoids are often tried. A positive effect is often counterbalanced by severe side effects, however, which may necessitate a discontinuation of therapy. In the case described, we report severe psychotic side effects, despite an improvement of pain perception. The symptoms were so severe that the patient was unable to fulfill her professional duties and even could not use an elevator.

Similar problems are well known for opioid therapy. With these drugs excellent analgesic effects can be counterbalanced by severe side effects, which can necessitate a disruption of therapy. In such cases, rotation from one opioid to another has proven to be successful. While the exact cause for the success of such a rotation remains unknown, the different affinity of opioids to an individual´s genetically determined mix of m-receptors and the subunit MOR-1 is suspected to be responsible.

Whereas both cannabinoids used for this patient presumably exert their action on the same receptors (CB-1 und CB-2), rotation proved very successful for the reduction of side effects. The analgesic effect was improved. Thus, the effect between the two substances was quantitatively and qualitatively different.

We can only speculate if the success of this cannabinoid rotation is caused by individual genetic differences at the receptor level or different affinities of the two substances to the receptors. However, we can state that, similar to opioid rotation, rotation of cannabinoids is a promising therapeutic option.” — Study

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Cannabis Research Library

Over 1000 studies covering over 130 topics compiled for easy browsing.