cbd oil for histamine

CBD Oil for Allergies

Allergy season will soon be upon us again. Here comes the not-so-fun part of Spring being right around the corner.

If you’re familiar with seasonal allergies, then you definitely know what I’m talking about. The weather is warming up, “spring is in the air”, the birds are chirping. but you can’t quite enjoy it because you’re constantly sneezing and itching your eyes!

10-30% of the global population is affected by seasonal allergies. This means that tens of millions across the globe experience allergies in one sort or another. Physicians, pulmonologists, clinicians, and specialists are just some of the few that are concerned with the increasing percentages of individuals who experience allergies today.

Standard decongestants, nasal sprays, and over-the-counter medications not working for you? Well, don’t lose hope just yet! There’s a natural, holistic alternative that may help those seasonal allergies, and who, nonetheless, then the lovely cannabis plant. Studies are showing that cannabis can help lessen the effects.

In today’s article, we’ll discuss some of the conventional and natural approaches to alleviating allergies as well as what the research is saying about the effects of cannabis on allergic reactions.


The endocannabinoid system (ECS ) is involved in numerous pathologies within the body. Receptors in the ECS, also known as endocannabinoid receptors, are located in the pain and inflammatory processing areas of the brain. Phytocannabinoids, for instance, modulate inflammatory responses within the body by regulating the production of cytokines (aka phytocannabinoids may help reduce inflammation).

Several recent studies point to the importance of modulating the ECS and the use of CBD oil as a potential therapy for allergies. So why haven’t we heard about this yet? Can CBD really reduce allergies? First, let’s talk about conventional allergy medications and their adverse effects.


By definition, an allergy is a misguided reaction to a foreign substance by the immune system . Allergies are the body’s way of protecting itself from invaders. However, allergic reactions can often be caused by harmless substances. Whether it’s a tiny piece of dust or pollen or something larger, like mold or grass, the body reacts – producing specialized antibodies to attack the “invader”. When antibodies are attacking the “invader”, this is when you may develop sneezing, watery eyes, inflammation, wheezing, or itchiness.

So when do you become allergic? According to John Hopkins Medicine , a person becomes allergic to something once their body has developed antigens against that substance. These allergic reactions begin in your immune system. The immune system consists of complex networks of cells and organs that work to protect the body from infection. You can think of your immune system as your own personal team of bodyguards, keeping you safe and away from harm.

This isn’t a small issue or one that should be overlooked. It is estimated that 40% of the world’s population has allergic responses to foreign substances in their everyday environment.


The allergies kick in not of nowhere and you’re not prepared. So you head to your local market for some allergy medication to help ease the sneezing and wheezing (hopefully). There are numerous over-the-counter (OTC) medications and prescriptions available to treat allergy symptoms. These allergy drugs include antihistamines, decongestants, and others to just name a few.


When you’re exposed to an “invader” or allergen, for instance, it triggers your immune system into a defense survival mode. The immune system consists of mast cells that release histamine. Histamine attaches to receptors in the blood vessels, resulting in larger blood vessels. These histamines can attach to other receptors causing itching, redness, and swelling.

However, by blocking these histamines from attaching onto nearby receptors, antihistamines can help prevent these symptoms from occurring or worsening. Commonly used OTC antihistamines are as follows:

  • Zyrtec
  • Allegra
  • Xyzal
  • Claritin
  • Alavert
  • Benadryl


These OTC antihistamines may help alleviate some of your symptoms over time, but there are some serious side effects associated.

  • Drowsiness
  • Dizziness
  • Nausea
  • Vomiting
  • Restlessness
  • Moodiness
  • Blurred vision
  • Confusion
  • Dry mouth


Decongestants may help relieve congestion caused by allergies. There are often prescribed as antihistamines. You can find decongestants in multiple forms: eye drops, nasal sprays, liquids, or pill forms. Common OTC decongestants are:

  • Sudafed
  • Afrin
  • Privine
  • Visine eye drops
  • Neo-Synephrine


Nasal decongestants may lead to a slew of potential adverse effects.

  • Stinging
  • Burning
  • Sneezing
  • Dryness
  • Irritation
  • High blood pressure
  • Rapid heartbeat
  • Anxiety
  • Dizziness


Some researchers may say “yes”. Cannabis may be helpful when it comes to reducing allergy symptoms. So what does the scientific research tell us about CBD and allergies? Unfortunately, there aren’t enough studies to say confidently that CBD can help with your allergies (yet). However, there are studies that support the idea and notion that cannabinoids can help play a role in reducing your allergies. Here are the cold, hard research facts:


One of the many ways that cannabis can help your allergies is through a reduction of the histamine released into your blood vessels. Histamine, as we discussed above, is released and triggered by your antibodies. So if we prevent or reduce the histamine from being released, this can make a huge difference! CBD oil can help in reducing the antibodies that trigger the histamine response.

A 2005 anti-inflammatory and cannabis study suggested that cannabis can help prevent an increased histamine response. Researchers found that exposure to tetrahydrocannabinol, THC, the psychoactive component of cannabis, could reduce mast cell activation. By reducing mast cell activation, there is less release of histamine to trigger allergic reactions.

This 2005 study concluded that THC may lead to reduced mast cell activation, leading to a reduction in the release of histamine, leading to possible prevention or reduction in the severity of your allergies.

For instance, a study published in the Journal of Leukocyte Biology suggested that cannabinoids impaired the activation of T-cells, a type of white blood cells. Since T-cells increase antibody activation and response, this leads to an increase in histamine, thus, leading to allergic reactions.

But, by impairing this activation, cannabinoids were able to reduce the antibody response and helped reduce allergy symptoms.

The terpenes present in cannabis have been shown to help too! A 2014 allergy study concluded that alpha-pinene, a terpene found in cannabis, can help reduce antibody levels. The animal study consisted of mice who were treated with terpenes and mice who were treated with a vehicle. Mice who were terpene-treated showed a decrease in clinical allergy symptoms as well as significantly lower levels of nasal antibodies that trigger histamine.

Mice treated with cannabinoids with terpenes showed decreased allergy symptoms.


While conventional allergy medications are commonly recommended or prescribed, all-natural, holistic alternatives aren’t quite there yet. Over the last 20 years, cannabinoid research and its effects on allergic reactions are making headway. CBD has been suggested to impair antibody responses and decrease allergy symptoms.

Until more research emerges and brings forth further findings of CBD oil and its allergy-reducing benefits, allergy sufferers will have to hold promise to the current research findings.

Curious about what Nanocraft Sciences has to offer? Keep reading!


Cannabinoid Options of Application:

Transdermal (Skin)- Topical Salve : This application is typically used for acute and direct application. Such as an ankle sprain, arthritis, tendonitis, plantar fasciitis, carpal tunnel, tennis elbow, fibromyalgia, and migraines. Full-spectrum salves provide a whole panel of cannabinoids for increased potency.

Edible CBD Applications:

CBD Oil Tinctures:

Tincture oils are utilized in full-spectrum form (whole plant derived) and Isolated forms (Pure CBD) that are applied directly under the tongue or mixed in water. This form is typically used for direct application to the central nervous system and the entire body for ailments like anxiety, stress, epilepsy, insomnia, sleep disorders, depression, PTSD, autoimmune responses, ADHD, cancer, systemic inflammatory disease such as cardiovascular disease, diabetes and metabolic syndrome. All applications are available as CBD isolate, broad spectrum and full spectrum.

CBD Soft Gel Capsules:

Full-spectrum soft gels essentially have the same application as tincture oils. The difference is that each soft gel is measured to a specific milligram to provide a consumer with a perfectly measured dose of CBD. This would be used for any ailments one might use CBD for, including all the ones listed above.

Check out our other posts for more information!

  • Using CBD Oil For Memory

* DISCLAIMER: The information in this article is for educational purposes only. It does not exploit or provide medical advice of any kind. Therefore, any reliance you place on the information below is strictly at your own risk. Please check with your medical provider before starting or changing a CBD routine.

CBD, Women, and Histamines – Nothing to Sneeze At!

Those are the common ones but there’s a host of symptoms that can result from the driver of an allergic reaction.

Okay….they sound an awful like PMS symptoms:

  • Headaches
  • Anxiety
  • Insomnia
  • Irritability
  • Brain fog

Maybe, more importantly, 65% of people who suffer from allergies are women!

Approximately 80% of people with histamine intolerance (the more severe end) are women and most of them over age 40!

Why is this and what does the type of CBD we use matter?

Let’s get into it!

You have may have an entirely different take on hormones after this.

You may also see your nose clear right up!

Histamine and Estrogen

First, let’s get to the bottom of that runny nose.

What’s causing all the commotion in the body when we come in contact with pollen, dander, or peanuts!

It’s part of our body’s immune response system to anything “foreign”.

We need it to protect us but occasionally, it might get “overprotective”.

If the immune system is on high alert, it can respond to things that aren’t dangerous to us.

Doug the Pug for example.

So why are women hit harder by allergies?

Ever notice how your allergies seem to change with your cycle?

There’s a direct connection between Estrogen levels and Histamine levels.

If estrogen goes up, histamine goes up.

When estrogen drops after a woman’s egg is released, histamine drops.

Interestingly, the body appears to lower its defenses in case there is a viable egg and placenta.

Maybe to protect a potential placental sac from being attacked by the woman’s body.

The sac is actually created by the man’s DNA and a woman’s body is itching to attack it!

We digress (but it’s weirdly interesting, right??)

All that matters for our discussion is that Histamine and Estrogen are intimately tied.

There’s a great resource regarding this for women who want to delve deeper:

This is SOO important for women and important for choosing CBD!

CBD Full Spectrum versus Isolate

There are lots of options but CBD currently comes in two distinct types.

Full Spectrum and Isolate.

Isolate generally starts from extracting just CBD as a crystal and then infusing it into a base oil (such as olive oil or MCT – a part of coconut oil).

Full-spectrum is more of the original hemp plant with dozens of other substances:

  • Other cannabinoids like CBG, CBC, CBN, etc
  • Terpenes
  • Flavonoids
  • Other plant materials

Everyone and their mother sells the “entourage effect” of having the whole plant together.

We generally run for doors when someone touts “synergistic” but more importantly, we’re not finding great research that this even exists.

In fact, the original root of the “entourage effect” related to how CBD offset some of the negative effects of THC.

The vast majority of the research is on isolated CBD and THC separately (which we don’t include since it’s psychoactive).

This makes sense since these two components generally make up 95% of the cannabinoids in the plant.

The issue is that all that “plant material” can cause adverse reactions in people with histamine issues!

No one’s talking about that.

We know that CBD by itself is showing promise regarding histamines in research.

CBD has even been shown to prevent mast cells from releasing histamines!

Again, this is CBD by itself that is being researched.

We’re not saying that the other substance in hemp oil doesn’t have benefits. it’s just not researched yet.

More importantly for the 30-40% (we think it’s higher) and probably 40-60% of women that have histamine issues…

One person’s superfood is another person’s poison!

Here’s an awesome resource on histamines themselves:

We know that CBD helps to calm the immune system and histamine is an actor in that system!

We see its positive effect in everything from itching (a direct result of histamine in the skin) to relaxing blood vessels (the opposite effect of histamine).

Check out the powerful connection between CBD and histamine for anxiety as an example.

Histamine is excitatory in the brain!

It eats up GABA which is the primary lever of benzos for anxiety.

Check out Can CBD boost GABA or CBD versus benzos for a complete rundown.

So CBD helps with allergic reactions but what about hemp oil (full spectrum essentially) and histamines?

Not much research there but lots of anecdotal results. from women!

Best CBD for Women with Allergies

Here’s my personal example…

I first tried the full-spectrum CBD from a major brand.

Organically grown. 3rd party tested. CBD levels verified.

I immediately felt anxious and had a fever-like response.

Yes, I’m one of the lucky women with allergy and histamines issues.

There are millions of us out there!

You can read all about similar results from women to full-spectrum.

I then tried a CBD isolate with MCT oil and loved it!

In fact, that’s what got me excited about finding the best CBD oil in its cleanest form for women like me – and voila! Indigo Naturals.

Let everyone sneeze their way through the day but I wanted to feel good.

Wasn’t that the point of CBD to begin with?

Here’s our recommendation if you really want to try full-spectrum hemp oil but have histamine issues.

Try the CBD isolate first.

Test it or 30 days which is about a 30ml bottle anyway depending on the dosage.

You can then try full-spectrum and see if you have a reaction to it.

Our concern is that a lot of women are going to try full-spectrum first since it’s pushed EVERYWHERE and not feel great on it.

They’ll stop using it and totally miss out on the benefits of CBD for women.

CBD is almost made for women in our modern world!

You can check out more on why CBD is so fitted for a women’s body (and brain!)

In the meantime, no more sneezing or itchy eyes.

Please. PLEASE let us know your results below.

Let’s help each other!

Always work with a doctor or naturopath with any supplement!

The information provided here is not intended to treat an illness or substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider.


We found out the hard way in the beginning after running through about 3-4 of the biggest brands of CBD. Total histamine response. We have a massive review on gut inflammation coming out shortly (search up top on site). Really fascinating and gut inflammation is the thermostat for the rest of the body (and brain). A few points. CBD isolate has been shown to calm histamine response (see CBD and mast cell activation). There are other tools we’ve found along the way for dysbiosis.

Vitamin D – critical player in immune response and gut barrier. Many people are deficient. I would put my money on this being the issue for immune hyperactivation and gut issues
Berberine – great tool for supporting microbiome and gut barrier (similar to metformin)
Oregano Oil – a powerful tool for dealing with pathogenic bacteria and overgrowth

Of course, we look at CBD and gut barriers in depth. There’s even new research on acetylcholine (can supplement choline) and the gut/brain axis via the vagus nerve. We’ll do a deep dive on that soon but check out review on acetylcholine. CBD isolate is a great tool for microbiome and gut health. It’s important to bring this under control as it’s the trojan horse for autoimmune and brain inflammation.

You’re not alone! Roughly 25-33% of people have an allergy to THC and all the plant material. CBD may help to counter that effect but really, it’s about calming your histamine response. You can test CBD prior to cannabis and see if there’s an impact. Let us know! Also, magnesium glycinate might help calm histamine response.

i seem to be allergic to weed can you stop that?

I’m a 33 year old male with hist issues due to dysbiosis, among a lot of other issues.

I just got restocked with full spectrum hemp cbd after 2.5 not being able to get it. First day I took a massive amount because I haven’t felt any major issues with it in the past, in fact over the course of 30 days it always fixes my gut. But because my histamine bucket was already filled… my left arm went numb, extreme pain in entire back and left arm. I thought I was having a stroke or something.

I then realized it was histamine as it calmed down at 2am, which the circadian rhythm tend to do as histamine slows down then. Now I found this article and it makes sense.

Thank you for sharing this! I feel more sane now, even though I’m having a major flare. Guess I gotta go a lot slower and with lower doses until gut clears up. Stay safe!

I love your website…..I am learning a lot from your articles. Yes, I have high histamine and have been using
a full spectrum CBD for a year. I’ve had itchy eyes, puffy eyes and tired more. Thank you so much. I’m going to
continue reading all your good information and try CBD Isolate. One question, does isolate have a positive affect
against diseases and they say full sprectrum does?

Cbd oil for histamine

To understand how Medical Cannabis works in the body as a mast cell stabilizer we must first understand how our Endocannabinoid system works.

What is the Endocannabinoid system (ECS)?

The endocannabinoid system (ECS) refers to a collection of cell receptors and corresponding molecules. You can think of cell receptors like little locks on the surface of your cells. The keys to these locks are chemical molecules called agonists. Each time an agonist binds to a cell it relays a message, causing a cascade of chemical effects.

The endocannabinoid system is the name for a series of cell receptors that respond to certain kinds of agonists. Two primary cell receptors make up the ECS, Cannabinoid Receptor 1 (CB1) and Cannabinoid Receptor 2 (CB2). The keys to these receptors are called endocannabinoids.

Endocannabinoids are like the body’s natural THC. In fact, endocannabinoids got their name from cannabis. Plant cannabinoids were discovered first. Endo means within, and cannabinoid referring to a compound that fits into cannabinoid receptors.

Cannabinoid Receptors

The cannabinoid receptors are found on the surface of the cells. Think of these receptors like a keyhole that will only function if the right key is inserted into it.

There are many types of cannabinoid receptors but only two of them have been widely studied and researched. They are CB1 and CB2.

Each receptor responds to different kinds of cannabinoids, but there are some cannabinoids that don’t distinguish between the two and can interact with both.

The distribution of these receptors within the body system explains why cannabinoids have certain profound effects on us.

CB1 receptors are abundantly present in the brain and spinal cord. They are found in exceedingly high concentration in the parts of the brain that are associated with the behaviors they influence.

Most importantly, they are found in the hypothalamus and the amygdala, which are responsible for appetite regulation, control of stress and anxiety, reducing nausea as well as for memory and emotional processing.

CB1 receptors are also present in nerve endings where they act to reduce sensations of pain (one major reason why cannabis is used as a pain killer).

CB2 receptors are usually located in the immune cells of the peripheral nervous system. Once activated, they trigger an immune response to reduce inflammation, a role that is important in treating many chronic diseases.

The presence of CB2 (and CB1) in immune system cells strongly suggests that endocannabinoids are immunomodulators.

CB1 and CB2 Suppress Mast Cells

Mast cells contain CB1 and CB2 receptors, which when activated inhibit mast cell release (R).

Research shows that cannabinoids can suppress mast cell degranulation.

“Cannabinoids are broadly immunosuppressive, and anti-inflammatory properties have been reported for certain marijuana constituents and endogenously produced cannabinoids. The CB2 cannabinoid receptor is an established constituent of immune system cells, and we have recently established that the CB1 cannabinoid receptor is expressed in mast cells. In the present study, we sought to define a role for CB1 in mast cells and to identify the signalling pathways that may mediate the suppressive effects of CB1 ligation on mast cell activation. Our results show that CB1 and CB2 mediate diametrically opposed effects on cAMP levels in mast cells. The observed long-term stimulation of cAMP levels by the Gαi/o-coupled CB1 is paradoxical, and our results indicate that it may be attributed to CB1-mediated transcriptional regulation of specific adenylate cyclase isoenzymes that exhibit superactivatable kinetics. Taken together, these results reveal the complexity in signalling of natively co-expressed cannabinoid receptors and suggest that some anti-inflammatory effects of CB1 ligands may be attributable to sustained cAMP elevation that, in turn, causes suppression of mast cell degranulation.“

A leading Mast Cell Activation Syndrome expert Dr. Afrin shares his experience with patients who use Medical Cannabis to help with their mast cell disease symptoms in his book Never Bet Against Occam.

“The mast cell surface features (inhibitory) cannabinoid receptors, making me wonder whether at least some of the chronically ill patients out there who claim that the only thing that makes them feel better is marijuana might be unrecognized MCAS patients in whom THC’s binding with the cannabinoid receptors on their dysfunctional mast cells leads to a quieting of the activity of those cells and thus a lessening of symptoms.“

*CBD alone without THC maybe ineffective at treating dysfunctional mast cells because THC has a strong binding affinity for both CB1 and CB2 receptors, cannabidiol (CBD) has no particular binding affinity. Instead, many of the therapeutic benefits of CBD are created through indirect actions.

In another research article,
“Cannabinomimetic Control of Mast Cell Mediator Release: New Perspective in Chronic Inflammation” published in the Journal of Neuroendocrinology provides detailed evidence backing up the fact that Medical Cannabis can suppress mast cell degranulation and help alleviate pain and inflammation in patients.

What Is the Best Way to Use Cannabis When You Have MCAS?

*Consult your doctor before making any change in your medical care. When trying Medical Cannabis remember that there are different strains of medical cannabis, one strain may give you great relief vs another may not.

If you’re considering using Medical Cannabis for Mast Cell Activation Syndrome you’re probably wondering how to take it. There are many Medical Cannabis treatment options available such as: Cannabis Edibles, Topical Ointments, Cannabis Oil, Smoking the Cannabis flower. However, when it comes to MCAS patients who are more severe, they tend to not tolerate ingesting the Medical Cannabis oil or edibles but may can inhale the actual Organic Medical Cannabis Flower and find great relief from MCAS symptoms.

“In the context of smoked marijuana, cannabinoids gain access to the systemic circulation within minutes of inhalation. However, airways and the gastrointestinal tract are immediate points of contact for cannabinoids constituents, and the resident mast cells in these areas will be impacted by marijuana smoke. Mast cells express CB2 cannabinoid receptors and a variety of responses to cannabinoid application have been described in these cells. In vitro, suppression of mast cell proinflammatory mediator release by both marijuana constituents and endocannabinoids has been described. The marijuana constituent tetrahydrocannabinol (THC) is highly suppressive in in vivo models of mast cell proinflammatory function.

It is recommended that MCAS patients only try organic medical cannabis as different pesticides and fertilizers can cause an allergic response. As with any medication there is a risk of an allergic reaction, so we encourage you to speak with your doctor.

Hemp Oil VS Medical Cannabis Oil

When trying Medical Cannabis Oil it is recommended to only use CBD/THC oils made strictly from medical marijuana for MCAS patients because of safety and superior medicinal benefits vs hemp.

CBD products made from hemp potentially have several problems:

Hemp contains less cannabidiol than CBD-rich cannabis strains so it takes a large amount of industrial hemp to extract a small amount of CBD. Hemp is also a “bio-accumulator” meaning the plant naturally drawns toxins from the soil which can cause issues in a MCAS patient.

Hemp-derived CBD and refined CBD powder lack critical medicinal terpenes and secondary cannabinoids found in cannabis oil. These compounds interact with CBD and THC to enhance their medicinal benefits.

MCAS patients want to make sure that the Medical Cannabis oil is CO2 derived as the other extraction process uses Ethanol (High-grade grain alcohol) and will likely cause anaphylaxis in Mast Cell Patients because Ethanol/Alcohol is known to cause mast cell degranalation.