cbd oil for health and wellness

For Your Health & Wellness: CBD oil, miracle cure or snake oil?

The cannabis plant, Cannabis sativa, contains a number of active ingredients, including THC and CBD. THC (tetrahydrocannabinol), the most active ingredient of marijuana, is the component that makes a person high when either smoked or ingested. Cannabidiol (CBD), on the other hand, is not psychoactive: it doesn’t induce a mind-altering effect.

CBD oil is a way of delivering CBD. This chemical is first extracted from the plant and then diluted with a carrier oil like hemp seed. It can then be consumed as either the oil itself or within drinks or confectionary. In the UK, it can be found in health shops.

How does CBD work?

The human body has two currently-known types of points where cannabinoids can bind, called CB1 and CB2 receptors. Cannabinoids can attach to the CB1 and CB2 docking points since they have a similar structure to the body’s naturally-occurring endocannabinoids. From here, CBD can impact movement, pain, emotions, mood and other functions regulated by endocannabinoids. This is still an area of active research and much of how it all works is still being explored.

Is CBD oil effective?

Many users of CBD oil claim it helps to relieve pain and inflammation, reduce anxiety and make them calm. Currently, scientific studies cannot say whether the small CBD quantities available in CBD products have any effect at all, but that hasn’t held back use. This is an area of ongoing research – we just haven’t reached a point where we have all the answers. Science is working to catch up with the demand.

CBD products available in health food shops and on the internet are not controlled or regulated as medicines, other than the legal limit on THC content. As doctors, we are advised to tell patients that ‘over-the-counter or internet’ CBD products lack quality assurance and should not be treated as medicines. There’s no way to be sure of what’s in the products you buy.

CBD products available in health food shops and on the internet are not controlled or regulated as medicines, other than the legal limit on THC content. As doctors, we are advised to tell patients that ‘over-the-counter or internet’ CBD products lack quality assurance and should not be treated as medicines. There’s no way to be sure of what’s in the products you buy.

What conditions can CBD oil help?

The list of things we’re told CBD oil can do for us is long, but there is still only preliminary evidence.

There is some belief that CBD is a natural painkiller. It’s also thought to have anti-inflammatory properties, and so it may help as a treatment for inflammatory diseases like Crohn’s disease. Indeed, some small studies in mice have supported this claim by showing that CBD significantly reduced chronic inflammation and pain. This has led hope that it may one day help chronic pain, but we won’t know until human tests are complete.

CBD is also believed to help people who suffer from anxiety and mood-related symptoms, as well as insomnia.

The condition that brought CBD oil to prominence is epilepsy. Scientific reviews have found that CBD has anti-seizure properties and there are several clinical trials well underway, some of which use pure CBD product. Stronger forms of CBD have been found to reduce the number of epileptic seizures suffered by some patients by more than 40%.

Source: Science Focus

Treating chronic pain in the right place: Remotely

By David Yarnitsky

An estimated 20.4 percent, or 50 million, Americans live with chronic pain, leading to nearly $560 billion each year in direct medical costs, lowering productivity and increasing disability. Today, chronic pain is one of the most common reasons for adults to seek medical care and has led to opioid dependence, anxiety, depression, restrictions in mobility and daily activities and overall reduction in quality of life. While short-term pain-relieving therapies provide relatively good solutions, an effective long-term solution for chronic pain has yet to be identified.

To establish what we are missing in chronic pain treatment, we first need to understand how the body perceives and responds to pain. Throughout the body we have pain-receptive neurons, known as nociceptors, which respond to damaging or potentially damaging stimuli by sending a “possible threat” signal. The signal travels through the nerves to the spinal cord, which processes the pain message and carries it up to the brain, where it is further processed by the thalamus and then sent to the cerebral cortex, where we perceive it.

Upon receiving a nociceptive pain message, the brain’s pain regulation network can either inhibit or enhance the pain experience according to the context. Typically, an acute pain message is often considered a “good” signal since it alerts the body to potential damage, allowing protective action that can thereafter be inhibited. Chronic pain, however, is usually a “bad” signal, reflecting some dysfunction of the system that fails to inhibit the pain and allows it to go on.

A common question that pain researchers face is why similar diseases or injuries cause varying pain levels in different people. We have come to understand that those living with a balanced pain regulation system are able to better inhibit unnecessary or non-threatening pain messages, while those with an imbalanced system lack this inhibitory capacity and are more susceptible to acute and chronic pains. Research has shown that patients with pain disorders such as migraine, tension-type headache, fibromyalgia, irritable bowel syndrome (IBS), temporomandibular joint disorder (TMD) and osteoarthritis usually have lower ability to inhibit pain.

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Individuals living with these chronic pain conditions often rely on over-the-counter (OTC) medications or stronger pharmacological solutions to block unnecessary pain signals. In fact, the global opioid market was sized at $25.4 billion in 2018. However, neither OTCs nor prescription pain medication are ideal for long-term use. Instead of developing more medication combinations for long-term pain management, it is time to rethink how we approach pain modulation altogether. With the advancement of technology in the medical device space, recent technologies are making it possible to treat pain conditions non-invasively.

Treating pain where it doesn’t hurt

“Pain inhibits pain” is a time-honored medical observation, where pain in one body site will be perceived as less intensive upon the introduction of another pain at a remote site. The underlying mechanism is the activation of internal inhibitory circuits evoked by the new remote pain that inhibit the original pain. When studying this mechanism in humans, we call this phenomenon “conditioned pain modulation” (CPM), a term that is often used to describe the process of endogenous pain inhibition.

In recent years, consistent data have accumulated demonstrating that CPM is less efficient in patients suffering from chronic pain, especially for those living with an idiopathic pain syndrome. That is, their ability to inhibit the perception of one pain by another is reduced—either as a cause or as a consequence of their chronic pain.

CBD Oil

The fastest and most effective delivery of CBD, our CBD Oil is meticulously formulated to deliver a high concentration of broad-spectrum CBD. Each bottle contains 30ml of rich phytocannabinoid oil, extracted with an e thanol extraction process from organic hemp plants, and blended with organic coconut oil as a carrier. To use, add to drinks, food, or take orally under the tongue. Organic, Zero THC, 100% vegan, gluten-free, non-GMO hemp, sugar-free, and cruelty-free.

Shake well before use. Take half to a full dropper as needed, directly under the tongue or in a beverage.

To start, shake the bottle well. For dosing, we recommend starting low and increasing dosing slow. Fill the tincture to the appropriate graduated markings and squeeze under the tongue to let the oil absorb for 30 seconds. Tinctures can also be mixed with food or drink as desired.

Take note of how your body has adapted to the cannabinoids on a daily and weekly basis and adjust your dosage based on your desired effect. For best results, we encourage you to stick with the same CBD routine for 30 days.

Mint – Organic MCT oil (coconut), Organic Peppermint, Organically grown hemp-derived Cannabidiol

Citrus – Organic MCT oil (coconut), Organic Citrus, Organically grown hemp-derived Cannabidiol

5 Hemp Oil Benefits For Health and Wellness

After almost a century of being outlawed, hemp—a form of cannabis with extremely low levels of psychoactive THC—is now legal in the United States. This is big news for people interested in the therapeutic effects of cannabidiol (or CBD) because—while hemp doesn’t contain enough THC, the compound that provides the “high” of cannabis, or any other psychoactive compounds—it does contain cannabidiol (CBD).

For years, all anyone talked about when they talked about cannabis was the THC content. Breeders focused on driving THC levels as high as possible and ignored the other compounds. Even pharmaceutical companies interested in the medical applications of cannabis focused on the THC, producing synthetic THC-only drugs that performed poorly compared to the real thing. It turns out that all the other components of cannabis matter, too, and foremost among them is CBD.

CBD doesn’t get you high, but it does have big physiological impacts. These days, researchers are exploring CBD as a treatment for epilepsy, anxiety, and insomnia. They’ve uncovered potential anti-inflammatory, anxiolytic, and immunomodulatory properties. And now that it’s quasi legal, hundreds of CBD-rich hemp oil products are appearing on the market.

What are the purported benefits of using CBD-rich hemp oil, and what does the evidence say?

Although CBD research is growing, it’s still understudied and I expect I’ll have to update this post in the near future with more information. But for now, here’s a rundown of what the research says.

1) Hemp Oil For Anxiety Reduction

Anxiety can be crippling. I don’t have generalized social anxiety, but I, like anyone else, know what it feels like to be anxious about something. It happens to everyone. Now imagine feeling that all the time, particularly when it matters most—around other people. The average person doesn’t consider the import and impact of anxiety on a person’s well-being. If CBD can reduce anxiety, that might just be its most important feature. Does it?

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Before a simulated public speaking event, people with generalized social anxiety disorder were either given 600 mg of CBD or a placebo. Those who received CBD reported less anxiety, reduced cognitive impairment, and more comfort while giving the speech. Seeing as how people without social anxiety disorder claim public speaking as their biggest fear, that CBD helped people with social anxiety disorder give a speech is a huge effect.

This appears to be legit. A placebo-controlled trial is nothing to sniff at.

2) Hemp Oil For Sleep

A 2017 review provides a nice summary of the effects of CBD on sleep:

In insomnia patients, 160 mg/day of CBD increased sleep time and reduced the number of arousals (not that kind) during the night.

Lower doses are linked to increased arousals and greater wakefulness.

High dose CBD improved sleep; adding THC reduced slow wave sleep.

In preliminary research with Parkinson’s patients, CBD reduced REM-related behavioral disorder—which is when you basically act out your dreams as they’re happening.

More recently, a large case series (big bunch of case studies done at once) was performed giving CBD to anxiety patients who had trouble sleeping. Almost 80% had improvements in anxiety and 66% had improvements in sleep (although the sleep improvements fluctuated over time).

3) Hemp Oil For Mental Health

While its psychoactive counterpart THC has been embroiled in controversial links with psychosis and schizophrenia for decades, CBD may be an effective counterbalancing force for mental health.

In patients with schizophrenia, six weeks of adjunct treatment with cannabidiol resulted in lower rates of psychotic symptoms and made clinicians more likely to rate them as “improved” and made researchers more likely to rate them as “improved” and not “severely unwell.” There were also improvements in cognitive performance and overall function. It seems the “adjunct” part of this study was key, as other studies using cannabidiol as the only treatment mostly failed to note improvements.

This was placebo controlled, so it makes a good case for CBD hemp oil as adjunct treatment (in addition to regular therapy) in people with schizophrenia.

Among 11 PTSD patients who took an average of 50 mg of CBD per day for 8 weeks, 10 (90%) experienced a 28% improvement in symptoms. No one dropped out or complained about side effects. CBD seemed to particularly benefit those patients who had issues with nightmares.

This is promising but preliminary. This was an 11-person case study, not a placebo-controlled trial.

4) Hemp Oil For Epilepsy

A recent review of four human trials lays out the evidence: More than a third of all epilepsy patients experienced 50% or greater seizure reductions with just 20 mg of CBD. The effect of CBD on seizure activity is so widely acknowledged and understood that the only FDA-approved CBD-based product is Epidiolex, a plant-based CBD extract used to treat seizures in patients with Dravet syndrome and Lennox-Gastaut syndrome.

CBD for epilepsy is legit. Side note: I wonder how CBD would combine with ketogenic dieting for epilepsy control.

5) Hemp Oil For Pain

By far the biggest draw for medical consumers of CBD is its supposed ability to nullify pain.

In one study, researchers induced arthritis in rats with intra-articular injections, then gave them CBD. Rats given CBD were able to put more weight on their joints and handle a heavier load before withdrawing. Local CBD reduced nerve damage.

That’s great for pet rats. What about people?

There actually isn’t a lot of strong data on pain management using CBD by itself. Far more robust is the evidence for using CBD with THC for pain. According to this group of researchers, the two compounds exert “constituent synergy” against neuropathic pain. One study found that low doses of each were more effective combined than high doses of either alone in neuropathic cancer-related pain. Another gave a THC/CBD oromucosal spray to otherwise treatment-resistant neuropathy patients, finding that the spray reduced pain, improved sleep, and lessened the severity of symptoms.

Anything Else?

Anecdotal evidence for pain relief and other benefits with CBD is vast. Chris Kresser, a practitioner and researcher I trust, swears by it. I have employees who use it quite frequently, reporting that it improves their sleep, hones their focus, reduces pain, speeds recovery, and reduces anxiety. These things are always hard to evaluate, but I can say that my people do great work, and I have zero reason to distrust them.

In later posts, I’ll probably revisit some of these other, more theoretical or anecdotal potential benefits to see if there’s any evidence in support.

Other Considerations…

Safety

A recent study gave up to 6000 mg of CBD to healthy subjects, finding it well tolerated and the side effects mild and limited to gastrointestinal distress, nausea, somnolence, headaches, and diarrhea. For comparison’s sake, keep in mind that a typical dose of CBD is 20 mg.

Mouse research indicate that extended high-dose CBD (15-30 mg/kg of bodyweight, or 1200-2400 mg per day for an 80 kg man) might impair fertility. Male mice who took high-dose CBD for 34 days straight experienced a 76% reduction in testosterone, reduced sperm production, and had dysfunctional weird-looking sperm. In the 30 mg/kg group, the number of Sertoli cells—testicular cells where sperm production takes place and sperm is incubated—actually dropped. Male mice taking CBD also were worse at mounting females and had fewer litters.

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Those are really high doses. For epilepsy, a common dose is 600 mg/day, and that’s for a severe condition. Most other CBD therapies use much smaller doses in the range of 20-50 mg/day. Long term safety may still be an issue at these lower doses, but we don’t have any good evidence that this is the case.

There’s some evidence that the dosages of CBD required to achieve anti-inflammatory effects are also high enough to induce cytotoxicity in healthy cells, though that’s preliminary in vitro (petri dish) research and as of yet not applicable to real world applications. Time will tell, though, as the legal environment opens up and we accumulate more research.

Is Isolated CBD the Same As Whole Plant Extracts?

As we’ve learned over the past dozen years of reading about nutrition and human health, whole foods tend to be more effective than isolated components. Whole foods have several advantages:

  • They contain all the components related to the compound, especially the ones we haven’t discovered and isolated. Supplements only contain the isolated compounds we’ve been able to quantify.
  • They capture all the synergistic effects of the multiple components working together. Isolated supplements miss that synergy unless they specifically add it back in, and even then they’ll probably miss something.

It’s likely that whole plant hemp extracts high in CBD are superior to isolated synthetic CBD for the same reason. Is there any evidence of that?

A high-CBD cannabis whole plant extract reduces gut inflammation and damage in a mouse model of inflammatory bowel disease. Purified CBD does not.

Even at a 2:1 CBD:THC ratio, co-ingesting isolated CBD with isolated THC using a vaporizer fails to reduce the psychotic and memory-impairing effects of THC. In another study, however, smoking cannabis naturally rich in both CBD and THC completely prevented the memory impairment.

And as we saw in the pain section above, THC combined with CBD seems more effective against pain than either alone.

That’s not to say isolated (even synthetic in some cases—see note below) CBD isn’t helpful. We saw it improve joint pain and reduce nerve damage in arthritic rats. It’s just that full-spectrum hemp oil containing multiple naturally-occurring compounds is probably ideal for general health applications. Specific conditions requiring high doses may be another question entirely. Again, we’ll find out as more research comes out.

A word about synthetics: this is fodder for a follow-up, but it appears there may be additional concerns with synthetic CBD, and even supposedly “natural” CBD companies have in some cases allegedly added ingredients to their formulas without letting consumers know.

Is It Legal?

CBD-rich hemp oil lies in a legal grey area. The recently passed Farm Bill allows people to grow and make products from industrial hemp, as long as it contains less than 0.3% THC. That means CBD derived from industrial hemp is legal at a federal level. But because the Farm Bill has provisions that allow states to set their own rules, legality at a state level is more complicated.

States where hemp is still illegal—South Dakota, Idaho, and Nebraska—do not permit the sale or use of hemp-derived CBD oil.

In states that permit recreational cannabis—California, Vermont, Massachusetts, Maine, Oregon, Colorado, Washington, Nevada, Michigan, and Alaska—CBD derived from both hemp and psychoactive cannabis is legal.

In all other states, hemp-derived CBD is legal.

The FDA has yet to approve of CBD, so most of the big online retailers like Amazon and Walmart don’t allow CBD products to be advertised. However, Amazon sells a ton of “hemp extract” tinctures and oils with “hemp extract content” listed in milligram dosages—a workaround for listing the CBD content.

If you’re looking for CBD-rich hemp oil, watch out for culinary hemp oil, which comes in larger quantities and has no discernible CBD content. CBD-rich hemp oil will come in dropper bottles, not liters.

You can also buy directly from manufacturers online who proudly advertise their CBD content. I’ve heard good things about Ojai Energetics and Sabaidee, though I haven’t used either.

Many health food stores sell it. Surprisingly, I’ve seen it in every pet store I’ve entered in the last half year.

Word of Caution: Because it isn’t regulated by the FDA yet, there’s no telling exactly what you’re getting. Choose a product with verifiable lab tests. Many CBD hemp oil products have far less CBD than advertised. In addition to CBD content, the most reputable manufacturers also test for pesticides, heavy metals, mycotoxins, and bacteria and advertise their results.

CBD-rich hemp oil is a hot topic these days, and it’s only going to get hotter. I think the compound shows great promise in promoting health and wellness, and I’ll look forward to doing more research as it unfolds.

For now, what about you? Do you use CBD? Have you noticed any benefits? Any downsides? Share your questions and feedback down below.