cbd oil for dogs dermatitis

Is CBD effective against dermatitis in dogs?

Mammals are a class of vertebrate living beings. The dog is an integral part of this class. It is one of the closest animals to man. They live together and benefit from each other. This is why man must take care of the dog of all the affections it can suffer. One of them is dermatitis. Is CBD an effective treatment for this canine disease? Yes, it is because it has anti-inflammatory properties. We will discuss the subject further in the rest of this essay.

What is canine dermatitis?

Commonly known as “atopic dermatitis,” this condition belongs to the category of inflammatory skin diseases. This one causes dogs to be very itchy. In veterinary jargon, experts refer to it as “pruritus”. Dermatitis is also known to cause redness in the dermis, rendering the impression that the dog is suffering from eczema.

Note that this infection usually develops on the ears, eyes, and the pet’s belly. Sometimes, atopic dermatitis does not spare its victim’s eyes either. Despite the fact that it is a widespread disease that only affects dogs, it is not as dangerous as it seems. However, for the dog to live in good conditions, it is necessary for the dog to undergo long-term veterinary treatment. Moreover, CBD is also known to overcome this chronic disease.

Dermatitis is a condition known to develop very early in dogs. Thus, it is possible that your pet may suffer from it if they are between six months and three years old. Since it is a chronic condition, your dog will never suffer from it again once it is cured.

What causes dermatitis in dogs?

The main cause of dermatitis is relative to the genetics of the dog suffering from it. In fact, you should know that certain breeds of dogs naturally have a certain predisposition to this disease. Bulldogs, Labradors, Boxers, and Beaucerons are the main breeds affected. When genetics are involved, dermatitis damages the protective barrier of the dog’s skin. Once it is weakened, the skin no longer plays its role. As a result, the animal’s skin becomes highly sensitive to allergens that swarm in the immediate environment.

In the dog, two types of dermatitis have been discovered. The first variant is known as “moderate dermatitis”. The latter is characterized by the occurrence of certain infrequent attacks. In most cases, it requires occasional treatment. The second type of dermatitis is the most severe form of dermatitis since it causes the animal to have very severe attacks. Unlike the first variant, severe dermatitis requires special attention as well as more than permanent treatment.

In addition to genetics, a disruption of the animal’s immune system can also cause the disease. Here, this disruption of the dog’s natural defenses is the basis for intrinsic dermatitis. It is so-called because its triggering factor is internal. Most of the time, the derangement we are talking about comes from food poisoning or the use of certain medications.

What are the symptoms of dermatitis in dogs?

The dog suffering from dermatitis becomes exposed to a multitude of allergens. Among these, it can be put forward dust mites, small insect bites without forgetting certain plants. Allergens contained in certain foods can also cause an attack. As soon as the animal comes into contact with the above-mentioned elements, an unprecedented itching reaction ensues. This leads to strong skin lesions. These are the typical symptoms of canine dermatitis.

However, the animal is also likely to develop non-typical symptoms. In this particular case, it is observable on its skin pimples as well as heavy bleeding. Sometimes, the lips and eyes are swollen. In terms of atypical symptoms, remember that the dog may engage in self-mutilation to relieve the itching caused by the disease. In this particular case, you will definitely notice the self-injurious markings involved.

Use CBD to treat dermatitis in dogs.

One of the most effective remedies for dermatitis turns out to be cannabidiol. In fact, the CBD oil for dogs marketed on our platform contains cannabidiol as well as CBDA. These are the two constituents that have shown great success in treating this infection in canines. This was demonstrated in a recent study. During this one, scientists were able to observe the reduction of itching provoked by the disease. Also, almost all owners reported no side effects following the treatment of the disease with CBD. Although steroids prescribed by veterinarians seem to work, they are not as effective as CBD. Therefore, CBD oil for dogs should not be overlooked in the fight against the development of dermatitis in the animal.

Is CBD oil the only effective form of cannabidiol?

It is possible that CBD could be used in any form to treat dermatitis in dogs. However, it is difficult to easily use the other forms of cannabidiol on the dog except for this oil. What makes this one practical is that it can be applied directly to the animal’s skin.

Should a veterinarian be consulted before any use of CBD oil on the dog?

It is vital to take professional advice before using CBD on the dog. This is to avoid possible overdose.

CBD Substantially Improves Atopic Dermatitis Symptoms in Dogs

SYDNEY , July 21, 2020 /PRNewswire/ –Animal health company CannPal Animal Therapeutics Limited (ASX:CP1) ("CannPal" or "the Company") has released results from its safety and efficacy study for DermaCann®, an oral nutraceutical developed for healthy skin and immune function for dogs.

Treatment with 2 similar DermaCann® formulations resulted in a substantial improvement in CADESI-4 scores, with an average reduction of 51% for dogs on treatment, compared to a slight increase observed in the placebo group between days 0 and 56.

CADESI-4 (Canine Atopic Dermatitis Extent and Severity Index) is a gold standard method used to grade skin lesions in clinical trials to assess the impact of treatments in dogs with Atopic Dermatitis.

Dosing for the safety and efficacy study commenced in Q4 2019 with 30 dogs expected to participate in the trial, however due to the social distancing measures implemented by the Australian Government in response to COVID-19, CannPal made the decision to finalise the study with 13 dogs having successfully completed treatment.

The study design was a randomised, double-blind, placebo-controlled clinical trial to assess the safety and efficacy of two similar DermaCann® formulations in dogs with dermatological skin conditions, using different sources of cannabidiol extracted from the hemp plant.

Dogs were dosed twice daily over a period of 56 days, with veterinary and owner assessments conducted on all dogs on (or around) Day 0, Day 28 and day 56.

Clinical assessments were completed by Dermatology Specialist Veterinarians using the validated CADESI-4 model to assess skin lesions in multiple areas classically affected by canine Atopic Dermatitis. Assessments of skin and coat health were also completed by the Dermatologists and dog owners.

There were no significant adverse events reported throughout and DermaCann® was well tolerated, with no dogs being withdrawn from the study.

CannPal will use the positive results from the trial as supportive efficacy data for the registration of DermaCann® in multiple markets as a nutraceutical for healthy skin and immune support for dogs.

The data has also been used to strengthen CannPals Intellectual Property portfolio, with the filing of the Company’s second PCT international ("PCT") patent application. This application is expected to establish an exclusivity period for the Company’s proprietary DermaCann® formulation extending to mid-2040.

CannPal has also advanced discussions with various animal health partners to progress the commercialisation of DermaCann® in markets that may not require product registration due to the relaxing of regulations for hemp-derived CBD.

CannPal Managing Director, Layton Mills

"We have had DermaCann® in development for close to 3 years now, and the result of that work is a safe and differentiated CBD product for dogs with a compelling dataset and strong Intellectual Property. To our knowledge, this will be the only clinically validated oral CBD pet nutraceutical for supporting skin health in dogs, and we look forward to furthering our commercialisation discussions for this exciting new product."

Use of Prednisolone, CBD and Behavior Modification as a Treatment for Atopic Dermatitis in a Canine: A Case Report

1 Department Of Animal Health Technology, Yamazaki University Of Animal Health Technology, Tokyo, Japan 2 Tokyo Animal Allergy Center, Tokyo, Japan 3 Nagoya Animal Allergy Center, Aichi, Japan 4 Department Of Gastroenterology And Gastroenterological Oncology, Fujita Health University, Aichi, Japan

* Corresponding Author(s):

Abstract

Introduction: Canine Atopic Dermatitis (CAD) is a chronic, pruritic skin disease. Although Cannabidiol (CBD) has neuroprotective, analgesic, anxiolytic, and anti-inflammatory effects, few studies have examined its use in dogs with CAD. This study aimed to evaluate the efficacy of CBD-containing hemp oil in combination with behavior modification therapy in the treatment of CAD.

Case presentation: A 48-month-old castrated male Maltese dog with a history of Canine Atopic Dermatitis (CAD) and adverse food reaction presented with genital licking behaviors that began approximately two years prior to presentation. The patient had received dermatological treatment two years prior to presentation, but the licking behavior continued. During the visit, the patient was diagnosed with stereotypical genital licking. The behavior was temporarily interrupted when the dog’s owner intervened verbally but would continue shortly thereafter. A diagnosis of obsessive compulsive disorder was made and behavior modification therapy was initiated. An elimination diet was prescribed and topical steroids were administered. These treatments alleviated the pruritis in the extremities but did not alter the frequency of genital licking. Therefore, Cannabidiol (CBD) was administered for 21 days after the initiation of the behavior modification therapy. Twenty-seven days later, the genital licking behavior decreased and could be stopped via verbal intervention from the dog’s owner.

Conclusion: In this patient, the stereotypical behavior was treated with CBD. Factors that contribute to stereotypic behavior are frustration and conflict. It is likely that the behavior began due to lack of care and unsatisfied motor drive. To date, potential efficacy has been reported in human dermatology; however, there have been no reports of CBD being used to treat CAD in dogs. These results highlight the importance of careful medical evaluations and treatment of a primary illness even when behavioral issues are prominent, as well as the potential use of CBD to treat stereotypical behaviors.

Keywords

Atopic dermatitis; Behavior therapy; Cannabidiol; Canine; Steroids

Introduction

Canine Atopic Dermatitis (CAD) is a chronic, pruritic skin disease that is seen with high frequency in veterinary clinics [1]. In atopic dermatitis, there is an excessive immune response in the skin, abnormalities in epidermal barrier function and scratching behavior [2]. Generalized pruritis is present in more than 40% of cases. Behaviors such as scratching, rubbing, and excessive grooming are seen due to the intense pruritis [3]. Acral lick dermatitis is a common skin disease in dogs caused by stereotypical licking of localized areas of the skin, such as the lower legs and armpits, and is believed to be caused by inadequate housing conditions and lack of social interaction and care. This behavior can be treated with serotonin modulators, suggesting an association with serotonin dysregulation [4].

Cannabidiol (CBD) is a non-psychoactive component of cannabis that has many beneficial effects on the body. CBD does not have a direct effect on the CB1 and CB2 receptors of the endogenous cannabinoid system, but has been reported to have neuroprotective, analgesic, anxiolytic, and anti-inflammatory effects. CBD and other hemp-derived natural constituents are expected to improve atopic dermatitis due to their involvement in the regulation of the endogenous cannabinoid system [5].

However, few studies have been conducted on the use of CBD in dogs with CAD [6]. The purpose of this study was to evaluate the efficacy of CBD-containing hemp oil in combination with behavior modification therapy in the treatment of CAD.

Case Presentation

A 48-month-old castrated male Maltese (2.5 kg) dog with a history of atopic dermatitis presented with stereotypical genital licking. The patient was obtained from a pet shop at the age of 2 months. From that time, frequent vomiting and diarrhea occurred and were effectively treated using an antidiarrheal drug. The patient was also noted to frequently have a decreased appetite. While the patient was walked outdoors for approximately 20 minutes per day, he did not urinate or defecate as he was focused on smelling the surroundings and scavenging for food. He swallowed anything he could put in his mouth. The patient played with toys with his owner twice a day and did not bark to make demands. The patient was kept within an enclosed area of the home with a place to urinate and defecate and an area to sleep when his owners were not home and overnight. Throughout the day, he independently went to his bed to lick his genitals or sleep.

At the age of 24 months, the patient’s hair began to change color as a result of licking his hind legs. He was treated with steroids, though the licking behavior would restart once the medication was discontinued. At 44 months of age, allergen identification and a lymphocyte reaction test were performed. The patient was identified as reactive to beef, pork, chicken, eggs, sheep, horse, turkey, duck, and salmon. He was diagnosed with Canine Atopic Dermatitis (CAD) and Adverse Food Reaction (AFR). A wheat-based diet resulted in normalized stools and appetite.

The patient also had a history of growling and was diagnosed with a learned behavior of defensive aggression for self-protection. Growling was observed during the consultation when the veterinarian attempted to palpate the patient and was reported to occur when the owners attempted to remove items from the patient’s mouth, stop the patient from licking his genitals, or take away toys or snacks. The patient was also diagnosed with pica based on reports of his behaviors during outdoor walks. The owner stated that the patient would put garbage and stones into his mouth that the owner was unable to remove.

The patient was treated with prednisolone (1.25 mg every 3 days), oclacitinib (0.9 mg/ day on days he did not take prednisolone), paracasei (lactic acid bacterium Lactobacillus paracasei: approximately 20 billion (live bacteria)/capsule, one capsule per day), and kestose (400 mg/day). On treatment day 35, CBD treatments were initiated. The patient was administered Sweet Potato Soft Chewables (3 mg CBD) (Treatibles; AD Remedies, Inc., TN, USA) three times daily. On treatment day 91, the CBD chewables were decreased to twice daily. On treatment day 94, the oclacitinib was discontinued. On treatment day 150, the prednisolone was adjusted to 1.25 mg every four days.

The patient was maintained on a wheat-based food (pure protein wheat), allergen-restricted diet with gluten-free quinoa biscuits as needed. Erythritol mist, an epithelial moisturizing bacteriostatic mist, was sprayed on the locations that the patient licked. On treatment day 53, the patient’s diet was changed from pure protein wheat to cod (Figures 1 & 2).

Figure 1: Schematic diagram of the treatment process. Changes in PVAS and the drug and CBD doses during treatment and at follow-up.BW, body weight; CBD, Cannabidiol; PVAS, Pruritus Visual Analog Score.

Figure 2: The axilla and forelimb after treatment. Discoloration of the coat has faded. The arrows show the lesion sites before and after treatment. The number of days corresponds to the time that has elapsed since the behavioral treatment was initiated.

Behavior modification methods

The patient’s strict diet was increased as needed when the patient’s desire to eat increased. The owner was instructed to make the patient walk faster so that he could not put foreign objects in his mouth while walking. When the dog tried to sniff the ground during the walk, she gave him a cue to “sit” and rewarded him if he sat down without sniffing. The owner was also instructed to hold the patient during outdoor walks, as needed. Due to the increased walking speed, the patient was allowed additional sleep time throughout the day.

To inhibit genital licking behavior, the patient was trained to obey the commands “sit,” “down,” and “wait” using positive reinforcement methods by rewarding with highly palatable, hypoallergenic treats. Treats were also used for counter conditioning to the licking behavior. In other words, the owner cued him to “come” when he tried to lick and rewarded him if he approached the owner without licking. During the follow-up period after behavioral modification began, aggressive growling and biting behaviors were no longer observed when the owner reached out while the patient was licking.