cbd oil for dementia & alzheimers

Alzheimer’s Disease

The most common form of dementia, Alzheimer’s disease, is a neurodegenerative disorder named for Dr. Alois Alzheimer who first diagnosed it in 1906 after performing an autopsy on the brain of a woman who died of an unfamiliar mental illness.

Although the exact cause of the disorder is not known, the disorder damages and eventually destroys brain cells, leading to memory loss and changes in thinking and other brain functions. Alzheimer’s usually develops slowly and gradually gets worse as brain function declines and brain cells eventually wither and die.

Symptoms of Alzheimer’s include:

  • Difficulty remembering newly learned information
  • Disorientation
  • Mood and behavior changes
  • Deepening confusion about events, time and place
  • Unfounded suspicions about family, friends and professional caregivers
  • Serious memory loss and behavior changes
  • Difficulty speaking, swallowing and walking

The most recent research, however, shows medical cannabis to be a viable treatment option for those suffering from Alzheimer’s and other neurological disorders.

How Can Cannabis Help?

The human brain is lined with endocannabinoid receptors that are responsible for regulating many body systems including mood, memory, pain, and appetite. When these communication pathways become clogged, as seen with amyloid plaques and tangles in Alzheimer’s patients, the ability to regulate these systems deteriorates, resulting in symptoms like memory loss and mood instability. Medical cannabis binds to the same receptors that the endocannabinoids do, some as perfectly as a key fits a lock, working to fill in the missing pieces of the healthy brain puzzle.

As pointed out by Dr. Sanjay Gupta’s “It’s time for a medical marijuana revolution” report, medical cannabis could significantly reduce the demand for pharmaceutical therapies, which often just add to the confusion and irritability of Alzheimer’s patients. Medical cannabinoids help to remove excess amyloid plaques from the brain by escorting them through the blood-brain barrier, thereby reducing the progression of Alzheimer’s and significantly reducing the severity of symptoms.

Medical cannabis research studies are returning hope to those suffering from Alzheimer’s and other neurological disorders and their loved-ones or caretakers with recent findings and conclusions that the benefits of medical cannabis treatments far outweigh any risks. It has been revealed that cannabinoids can slow or even halt the progression of Alzheimer’s disease by improving the condition of communication pathways in the brain. THC, the best-known psychoactive cannabinoid, prevents brain-clogging plaques from growing larger or from even forming in the brain altogether.

What Does The Research Say?

In a 2006 study by Kim Janda, Ph.D., Janda stated that the study shows “that there is a previously unrecognized molecular mechanism through which THC may directly affect the progression of Alzheimer’s disease.” Janda’s team found that THC limits the progression of the disease by blocking an enzyme called acetylcholinesterase. This enzyme speeds the formation of amyloid plaque in the brains of people with Alzheimer’s disease.

In March of 2014, research experts concluded that CBD, the best-known non-psychoactive cannabinoid in medical cannabis, can actually improve the memory loss and mood instability symptoms experienced by those suffering from Alzheimer’s disease. CBD works to reverse the neurological damage in the brain caused by Alzheimer’s by establishing new neurons, in a process called neurogenesis. At the same time, CBD helps to strengthen the body’s natural defenses, allowing the immune system to work smarter in the battle against Alzheimer’s disease.

Links to Research

Neuroprotective effect of cannabidiol.

A Molecular Link Between the Active Component of Marijuana and Alzheimer’s Disease Pathology

Cannabinoids for treatment of Alzheimer’s disease: moving toward the clinic.

Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress.

While research has shown cannabis to be effective in providing palliative and therapeutic effects for some patients, always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition and before starting any new treatment utilizing medical cannabis or discontinuing an existing treatment. The content on this site is not intended to be a substitute for professional medical advice, diagnosis or treatment.

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More Arizona Caregivers Looking To CBD, THC To Help Dementia Patients

Alzheimer’s disease and other dementias can take a toll on both caregivers and the person living with the disease. As it advances, those living with the disease can develop behaviors like anxiety, restlessness and even aggression. Antipsychotics are often prescribed, but there are side-effects. Some providers and caregivers are looking at medical cannabis as an alternative.

“I know exactly when the red flag went up,” said Sandy Mercer.

Mercer is talking about the first time she noticed something was really wrong with her mother, Irene.

“Prior to that I thought it was old age. She was 89,” said Mercer.

Mercer and her mother had taken a trip back to the East Coast, where they were from.

“And on Saturday morning, I got up and she was putting her eyebrows on with a ball point pen,” she said.

Like Mercer said, there were signs. Irene was eventually diagnosed with Alzheimer’s disease. Mercer tried to care for her mother for about a year without any support, but like a lot of people with Alzheimer’s, Irene developed behaviors.

“She would be walking around the house looking for her mother, who died when she was in her 20s, you know, and saying, ‘I need to go home, where’s my home?'”

Irene was sundowning. Sundowning is a symptom of Alzheimer’s disease. It typically occurs later in the afternoon or early evening and it’s an especially difficult behavior to manage — it can trigger restlessness, confusion and agitation.

At that point, Mercer had joined an online support community.

“And in that online support group is where I started seeing mentioning of medical marijuana to help out with the sundowning,” said Mercer.

Although medical marijuana is still illegal at the federal level, most states have legalized its use, including Arizona. Still, using medical cannabis to treat dementia patients isn’t typical among providers.

As for the dispensaries, Mercer said “they were always nice but they didn’t have that education on using marijuana for an Alzheimer’s patient.”

So Mercer did her own research. She also obtained medical marijuana cards for both herself and her mother.

“It was more or less trial and error,” she said.

She said she used herself as the guinea pig.

It took her a while to find the right combination of THC, the psychoactive compound in cannabis, and CBD, a non-intoxicating cannabinoid found in hemp (which is legal, as long as it doesn’t contain more than 0.3 percent THC).

“And what I would see is that she wouldn’t go into that acute afternoon sundowning, which was the most important, where she was like pacing back and forth and wanting to leave the house,” said Mercer.

Mercer’s mother could have been the exception, or maybe she was the rule. But more and more caregivers, even some providers, are considering alternatives like CBD and THC.

In June, the community group Dementia Friendly Tempe hosted a talk about medical marijuana and dementia. It was a packed house.

Jan Dougherty is the special projects coordinator with the Banner Alzheimer’s Institute. She helped facilitate the meeting.

“And so caregivers are saying, “hey, I heard marijuana is being used or somebody is using gummies,” and we just felt it was time to have an informed talk by a physician to really help caregivers and the general community understand what marijuana may do or may not do and the reality is, we don’t really know,” said Dougherty.

So Dementia Friendly invited Dr. Walter Nieri, a geriatrician with the University of Arizona College of Medicine, to talk about medical cannabis.

Nieri, a dementia specialist, is in the early stages of a small study — so far, only 10 to 15 participants — that will look at the effects of medical cannabis in patients who have dementia with behavioral problems. But because cannabis is still illegal at the federal level, he has to conduct his study at a long term care facility that does not receive federal dollars.

“To be quite frank with you, I’m kind of desperate because all of the medicines we traditionally use all have side effects,” said Nieri.

Like Seroquel, Zyprexa and Risperdal, which are all antipsychotics and mood stabilizers such as Depakote, and the risks associated with those drugs, he says, often outweigh the benefits.

“So, I’m looking for another alternative and if that would be marijuana that would be good,” said Nieri.

Nieri says some preliminary studies have already shown some promise.

“But I have to do it very carefully on our dementia patients, because they’re also on other medicines and I don’t know the drug-drug interaction,” said Nieri.

‘Reefer Madness’

Even if Dr. Nieri proves that medical cannabis can help curb behaviors and improve quality of life, will those with the disease and their caregivers seek it out?

According to the Arizona Department of Health Services, as of June 2019, only 105 people listed Alzheimer’s as the reason why they obtained a medical marijuana card — there are currently more than 200,000 card holders in the state.

” This current group of older adults remember they grew up a in a time where marijuana was very much frowned upon,” said Dougherty.

“Reefer Madness” was a 1936 film that depicted the downward spiral of two teenagers who tried marijuana. While the film might have scared an entire generation, it may not be the same for Baby Boomers.

“The discussion in the Boomer group will be a bit different, because this is a group where it was readily available,” said Dougherty. Many of them did experiment or have continued to use marijuana throughout their lives, obviously under the radar, if you will.”

For Dougherty and others, one big take away from Dr. Nieri’s talk is that, besides studies, conversations need to happen between patients, families, providers, social workers and even those who work in the cannabis industry. Because in order to do no harm, everyone has to be part of this important conversation.