cbd oil dosage for seizures in adults

A Quick Guide to CBD Oil Dosage for Seizures

Although cannabis products have been seen as taboo for many years, the science doesn’t lie. A study conducted by Johns Hopkins revealed that CBD products can actually help people with their anti-seizure medications as well.

Have you ever thought about using CBD oil to help manage your seizures? Here is a handy CBD oil guide to finding the best CBD oil dosage and choosing a product that works for your needs.

Talk to Your Doctor First

No matter what, you should always talk to your medical team before starting any new regimen, including CBD oil. This is because you do not know how your body will react to the ingredients, or how they can interact with your other medications.

These interactions could cause potentially drastic side effects. Your doctor may also give you advice for how to start with CBD oil dosage or recommendations for reputable CBD companies.

Start With a Low Dose

When starting any new medicine, it is always best that you begin with the smallest dose and work your way up. This way, you can avoid complications like the side effects of accidental overdose.

Many users find substantial relief even from using the lowest dose of CBD. Unless your doctor or another professional recommends otherwise, you can feel comfortable taking between two and five milligrams of CBD. For children, you may want to start with an even lower dose.

Calculate Dosage Based on Weight

Another way to calculate CBD dosage is by using your weight. This will help you to prevent overdosing because your weight helps determine how your body responds to cannabis products. Click here for CBD oils and other products that can get you started.

Once you find your baseline dose, you can use a chart to determine how much you need based on the desired effect and your weight. For example, if you have severe seizures, you may require a high amount of CBD, and you can combine that with your weight for the correct number.

Look Out for Side Effects

Whenever you find a new CBD product, you should always monitor for side effects. One of the best ways to treat seizures is with CBD oil. CBD oil dosage can be tricky, so be sure to use the correct amount. If not, you can have side effects such as tremors and lightheadedness.

If you see any unpleasant side effects, scale back or stop your usage of CBD immediately. You may even want to discuss this with your doctor before continuing.

Find the Correct CBD Oil Dosage for Seizures

If you or a loved one suffers from epilepsy, you may be able to use CBD oil to lessen your symptoms. With this guide to CBD oil dosage for seizures, you can find the perfect amount that will help you to manage your seizures in a more natural way.

Would you like to learn more about how you can use natural ingredients to improve your health, rather than relying on pharmaceuticals? Check out our site for more tips and tricks on combatting illness with homeopathic ingredients.

A Study to Investigate the Efficacy and Safety of Cannabidiol (GWP42003-P; CBD) as Adjunctive Treatment for Seizures Associated With Lennox-Gastaut Syndrome in Children and Adults (GWPCARE4)

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information

Ages Eligible for Study: 2 Years to 55 Years (Child, Adult)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No

Key Inclusion Criteria:

  • Participant must have been male or female aged between 2 and 55 years (inclusive).
  • Participant must have had a documented history of Lennox-Gastaut syndrome. This included written documentation of having met electroencephalogram (EEG) diagnostic criteria during the participant’s history and evidence of at least 1 type of generalized seizure, including drop seizures (atonic, tonic, tonic-clonic or myoclonic) for at least 6 months.
  • Participants had a history of slow (<3.0 Hertz) spike-and-wave pattern in an EEG prior to the enrollment into the baseline period.
  • Participants were refractory; that is having documented failures on more than one antiepileptic drug (AED).
  • Participant must have been taking 1 or more AEDs at a dose which has been stable for at least 4 weeks prior to screening.
  • All medications or interventions for epilepsy (including ketogenic diet and vagus nerve stimulation [VNS]) must have been stable for 4 weeks prior to screening and participant is willing to maintain a stable regimen throughout the study. The ketogenic diet and VNS treatments are not accounted as an AED.

Key Exclusion Criteria:

  • Etiology of participant’s seizures was a progressive neurologic disease. Participants with tuberous sclerosis were not excluded from study participation, unless there was a progressive tumor.
  • Participant had an anoxic episode requiring resuscitation within 6 months of screening.
  • Participant had clinically significant unstable medical conditions other than epilepsy.
  • Participant had clinically relevant symptoms or a clinically significant illness in the 4 weeks prior to screening or randomization, other than epilepsy.
  • Participant was currently using or has in the past used recreational or medicinal cannabis, or synthetic cannabinoid based medications (including Sativex®) within the 3 months prior to study entry and was unwilling to abstain for the duration of the study.
  • Participant had any known or suspected hypersensitivity to cannabinoids or any of the excipients of the Investigational Medicinal Product (IMP), such as sesame oil.
  • Participant had been part of a clinical trial involving another IMP in the previous 6 months.
  • Participant had significantly impaired hepatic function at screening or randomization (Alanine aminotransferase [ALT] >5 x upper limit of normal [ULN] or total bilirubin [TBL] >2 x ULN) OR the ALT or Aspartate aminotransferase (AST) >3 x ULN and (TBL >2 x ULN or international normalized ratio >1.5). This criterion can only be confirmed once the laboratory results are available; Participants randomized into the study who are later found not to meet this criterion should be withdrawn from the study.
  • Any history of suicidal behavior or any suicidal ideation of type 4 or 5 on the Columbia Suicide Severity Rating Scale in the last month or at screening.
  • Participant was taking more than 4 concurrent AEDs.
  • Participant was taking corticotropins in the 6 months prior to screening.
  • Participant was taking long-term systemic steroids (excluding inhaled medication for asthma treatment) or any other daily medication known to exacerbate epilepsy. An exception was made of prophylactic medication, for example, idiopathic nephrotic syndrome or asthma.
  • Participant was taking felbamate, and they had been taking it for less than 1 year prior to screening.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Valproic acid – Brand names: Belvo, Depakote, Dyzantil, Convulex, Syonell

Valproic acid is used to treat bipolar disorder.

It’s occasionally used to prevent migraine and can also be used to treat epilepsy.

This medicine is only available on prescription. It comes as capsules or tablets.

If taken during pregnancy, valproic acid can cause problems for a baby’s development, including birth defects and long term learning difficulties. For this reason, valproic acid is not recommended if there’s a chance that you could become pregnant.

For women and girls of childbearing age, if you do need to take valproic acid then your doctor will put you on Prevent, the valproate pregnancy prevention programme.

Valproate pregnancy prevention programme

The valproate pregnancy prevention programme is very important and is still running during the coronavirus (COVID-19) pandemic.

You should be reviewed every year by your doctor or nurse who will talk to you by video or phone call if you cannot attend your surgery in person. They will assess whether you need to continue taking valproic acid or whether it is possible to change your medicine.

If you do need to continue taking valproic acid then you must be using reliable contraception, even if you are not currently sexually active. Your doctor or nurse can advise you about reliable contraception. You will be asked to sign a form to say that you are using contraception and understand the risks of becoming pregnant while taking valproic acid.

It's important to get advice as soon as possible if you think you are pregnant or might become pregnant while taking valproic acid. However, do not stop taking your medicine suddenly without talking to your doctor first.

Updated: 3 September 2021

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2. Key facts

  • You’ll usually take valproic acid 2 or 3 times a day. You can take it with or without food.
  • You’ll usually start on a low dose. Your dose will gradually increase over a few days or weeks. and semisodium valproate are similar to valproic acid and work in the same way. However, these medicines are used to treat different conditions and doses will vary.
  • There are also brands such as Epilim Chrono, Epilim Chronosphere and Dyzantil which contain mostly sodium valproate, with some valproic acid.
  • If you’re pregnant, or there’s a chance you could become pregnant, valproic acid is not recommended for treating migraine. For epilepsy and bipolar disorder, your doctor will only prescribe valproic acid for you if there are no other suitable treatments.

3. Who can and cannot take valproic acid

Adults and children can take valproic acid to treat bipolar disorder or epilepsy.

Adults, aged 18 and above, can take it to prevent migraine.

Valproic acid is not suitable for girls or women who could become pregnant. However, in some cases it may be the only treatment option available, for example, for epilepsy where other treatments have not worked. Girls and women who need to take valproic acid must be on Prevent, the valproate pregnancy prevention programme.

To make sure valproic acid is safe for you, tell your doctor if you:

  • have ever had an allergic reaction to valproic acid or any other medicine
  • have liver problems
  • have a rare metabolic or genetic condition such as porphyria, urea cycle disorder or mitochondrial disorder

4. How and when to take valproic acid

Valproic acid is a prescription medicine. It’s important to take it as your doctor tells you.

Dosage

The usual dose for treating bipolar disorder for:

  • adults – 750mg to 2,000mg a day, split into 2 or 3 doses
  • children – the doctor will work out the right dose for your child

The usual dose for preventing migraine for:

  • adults – 500mg to 1,000mg a day, split into 2 or 3 doses

The usual dose for treating epilepsy for:

  • adults and older children (aged 12 years and over) – 600mg to 2,000mg a day, split into 2 to 4 doses
  • younger children (weighing more than 20kg) – the doctor will use your child’s weight to work out the right dose for them

If you need to take your medicine more than once a day, you’ll take equal doses that add up to your daily total. Ask your doctor or a pharmacist if you’re unsure how much to take each time.

If you’re taking valproic acid and have kidney problems, your doctor may prescribe a lower dose.

How and when take it

Valproic acid comes as gastro resistant tablets and capsules. These release the valproic acid into your body as soon as they pass through your stomach.

Swallow the tablets or capsules whole with a drink of water or juice. Do not chew them.

You can take valproic acid with or without food, but it’s best to do the same each time.

If you’re taking valproic acid twice a day, try to leave a gap of 10 to 12 hours between doses. For example you could take your first dose in the morning (between 7am and 8am) and your second dose in the evening (between 7pm and 8pm).

If you take it 3 to 4 times a day, try to space your doses evenly throughout the day. If you need to take 3 doses, for example, you could take a dose first thing in the morning, early afternoon and bedtime.

Will my dose go up or down?

To reduce the chance of side effects, your doctor will start you off on a low dose of valproic acid. They will increase it gradually over a few days or weeks.

Once you find a dose that suits you, it will usually stay the same, unless your condition changes, or your doctor starts you on a new medicine that may interfere with valproic acid.

What if I forget to take it?

If you forget a dose, take it as soon as you remember, unless it’s less than 2 hours to your next dose. In this case, skip the missed dose and take your next one at the usual time.

Never take 2 doses at the same time. Never take an extra dose to make up for a forgotten one.

If you have epilepsy, it’s important to take this medicine regularly. Missing doses can trigger a seizure.

If you often forget doses, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to help you remember to take your medicine.