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Cushing’s Disease In Dogs: What You Should Know

Many are aware that Cushing’s Disease in humans is a relatively well-known thing. However, some may wonder what Cushing’s Disease in dogs is. Unfortunately, in many cases, it can go unnoticed, which is why it’s important to be aware of this illness!

Typically, Cushing’s Disease for dogs is recognized by adrenal glands that have become hyperactive. Consequently, it can have some nasty effects for your pooch. Having an understanding of what Cushing’s in dogs is, what symptoms to look for and the potential treatments can give your pet a better chance of living a happy, healthy life.


What Is Cushing’s Disease?

To put it simply, Cushing’s Disease occurs when the dog’s body begins to create levels of cortisol that are higher than the body can handle. Typically, the hormone cortisol is made by the adrenal glands, which is why the illness can often be called hyperadrenocorticism.

When there is too much cortisol in the body, issues can show up. When the adrenal glands are working normally, they do a number of things like handling stress, regulating metabolism, blood glucose, and blood pressure. As you can imagine, when these things lose their balance, a lot can go wrong in the body very quickly. Some may also refer to it as Cushing Syndrome in dogs.

The Role Of ACTH

Typically, when the cortisol hormone is released, it’s in response to another hormone known as ACTH. ACTH is created by the pituitary gland and releases when blood sugar is low or when other external stressors take place. As a result, more cortisol is created, which heightens the blood sugar levels by changing proteins and fat into glucose. Consequently, issues with the pituitary glands can also effect the adrenal glands and their creation of cortisol.

ACTH tests can help vets to diagnose issues with the adrenal glands. If the ACTH is added, and the cortisol response is much higher or lower than normal, it can signify problems with the glands. Essentially, the test requires an ACTH injection followed by taking blood.

Understanding Pituitary Adenoma

Adenomas are tumors that can form on the pituitary glands. They are typically benign, but they can have an effect on how functional those glands are. When adenomas are functioning, they are able to still create ACTH. When they are non-functioning, that hormone isn’t created.

However, the non-functioning adenoma can cause a build-up of pressure in the surrounding area. It’s also important to remember that there can be heightened levels of ACTH in the body when the adenoma is functioning and the glands are creating the hormone as well.

As a result, there’s a lot of extra cortisol floating around, which is often the primary cause of Cushing’s Disease in dogs.

Important Things To Know

There are a few things worth keeping in mind when it comes to Cushing’s Disease in dogs. The first is that it’s highly treatable once your vet has diagnosed the issue. Furthermore, keep in mind that canines with Cushing’s Disease can still have a decent lift expectancy.

Furthermore, there are a lot of symptoms that can come with this disease, so anything that seems odd should warrant a trip to the vet. It’s also typically an issue that occurs in older dogs rather than younger ones.

While it can be mixed up with Addison’s Disease because these are diseases that can mimic Cushing’s signs, Cushing’s is actually on the opposite end of the spectrum.

Finally, breeds that are more susceptible to this issue are:

  • Boston terriers
  • Labrador retrievers

Keep in mind that dogs of any breed, size, gender, or age can develop Cushing’s Disease. Make sure that you keep an eye out for the signs and contact your vet if you notice your dog behaving abnormally. That way, any issues can be resolved quickly.

Cushing’s Disease Causes

When it comes to what causes Cushing’s Disease, there are two situations that unfold with this illness. The most common is a type considered to be pituitary-dependent.

As we’ve discussed, this includes the presence of a pituitary adenoma. This type of Cushing’s disease usually makes up around 80% of all cases. On the other hand, the remaining 20% often results from tumors that have occurred in the adrenal gland.

In most cases, medication can keep pituitary adenomas under control pretty well. However, in some cases, they can become macroadenomas, which are those that have grown larger than 1cm in size. Because of this growth, they can place a lot of pressure on the surrounding tissues.

About 15% of pituitary adenomas become macroadenomas, which can add other neurological symptoms due to the size on top of the Cushing’s symptoms. In these cases, the prognosis can become much less bright. It’s in these most extreme cases that you’ll want to work with your vet to keep your dog happy and comfortable for as long as possible and knowing when you might need to put a dog down with Cushing’s Disease. Luckily, those are very uncommon circumstances.

The good news is that benign macroadenomas can be removed through surgical means, which can provide a great solution. Malignant tumors can also be removed, but tend to have a lot more complications.

For the most part, handling dogs and Cushing’s Disease can be quite manageable with the use of surgery and medication.

Symptoms Of Cushing’s Disease In Dogs

Ultimately, tests will need to be performed in order to determine if your dog has Cushing’s disease, but there are some symptoms that can help to signify what might be going on.

Cushing Disease in dogs symptoms can include:

  • Heightened thirst
  • High amounts of urination
  • An appearance of being pot-bellied
  • Skin-thinning
  • Dry skin
  • Heightened appetite
  • Compromised immune system
  • Urinary accidents
  • Obesity
  • Frequent bruising
  • Scaly patches on various areas

In some cases, you may notice many symptoms, while in others you may only see one or two. Keeping an eye out for them is key! Even if they don’t signify the presence of Cushing’s in dogs, they can be signs of other issues going on that likely need to be addressed. You really can’t go wrong with getting your pet checked out when you notice signs like excessive thirst in dogs or urinary accidents.

How Vets Diagnose Cushing’s Disease

When you notice any of the signs of Cushing’s in dogs mentioned earlier and get your dog to the vet, they will then need to check your pet out and run some tests to get to the root of the issue. Here, we’ll discuss some of those tests.

Tests Included

For the Cushing’s Syndrome diagnosis, the tests your vet will conduct can be incredibly helpful because the symptoms can be very similar to other diseases, such as Addison’s disease and diabetes. However, Cushing’s and Addison’s effect on the body quite differently. Consequently, it’s important that tests for serum biochemistry, cell counts, and others are extremely helpful.

When the situation is narrowed down, a low-dose dexamethasone suppression test can be key for diagnosing Cushing’s Syndrome in dogs. Like the ATCH test, this test will show differences in the cortisol levels found in your dog’s blood. A normal response includes a decrease in cortisol, while a test positive for Cushing’s will show no difference.

In some cases, sinus sampling can also be a method used for diagnosing Cushing’s in dogs. However, this is a more invasive option. Both of the tests listed here are quite reliable, so you’ll be able to trust that a diagnosis of Cushing’s is very accurate.

Cushing’s Disease Treatment

One of the first things pet owners are likely to wonder is how long their dog can live with Cushing’s Disease, or whether or not their dog is in pain.

While there are no cures for Cushing’s Disease in canines, there are management options that can help your dog to live a long, happy life. After your furry friend has been diagnosed, your vet can help you find the best path!

If you want to cover all your bases, it can also be very helpful to ask your vet about the recommended diet for canines with Cushing’s Disease.

Medications commonly used for Cushing’s Disease are:
  • Nizoral
  • Selegiline
  • Carbex
  • Anipryl
  • Lysodren

Typical Prognosis Information

Generally speaking, your dog can absolutely still live a long, happy life with this illness. This prognosis only really changes when there is a large tumor present or a malignant one. Neither of these illnesses is a very common occurrence.

Looking After Dogs With Cushing’s

Canine Cushing’s Disease isn’t something that can typically be prevented, so don’t beat yourself up if you discover your dog has it. Furthermore, in most cases it doesn’t cause any major problems with regard to the quality of life your dog has. In most situations, medications that include trilostane vetoryl are used for this disease, and assist in regulating the illness. You may want to take a look at vetoryl side effects, to gain a deeper understanding of this medication.

The sooner you catch the signs and get your canine companion to the vet, the better off they’ll be. With early medications and treatment, it shouldn’t cause your dog too many issues. With the right care, your dog will be back to romping around happily before you know it.

It’s not worthwhile to allow a dog with Cushing’s Disease to go untreated. As you can imagine, the Cushing Symptoms in your dog can become a lot worse, and result in a lower life expectancy.

Are There Cures For Cushing’s?

Currently, there are no known cures for Cushing’s Disease in dogs, but it can be managed through the use of medication, and in some cases surgery. The sooner you catch the symptoms of Cushing’s in dogs and have your dog diagnosed, the easier it will be to get your dog back into decent health. As with any other illness, it’s important to have a good understanding of how your dog behaves normally, so that you can catch any small changes that may indicate the beginning of Cushing’s Syndrome.

How Can CBD Help?

While CBD may not be a cure-all for diseases like Cushing’s, it can be an option to help with soothing pain and assisting your dog’s health overall. It’s a fantastic supplement that you can use whether your dog is healthy or needs a little help. It’s also a fully natural option.

If you’d like to use CBD to help your dog, it can be a good idea to check with your vet, just to make sure it’s okay. Although it doesn’t tend to have any side effects for you to worry about, it’s always a good idea to check, because every dog is a little bit different.


For those who are interested in ease of use, Innovet Pet’s CBD Oil is a great option. This fully organic option is tested and proven to be safe for your pet. It’s made to provide them with the benefits they need, without any negative effects. It doesn’t contain any THC, so there won’t be any “high” that your dog experiences.

Instead, they’ll receive benefits that can assist them with joint and digestion help as well as help with anxiety and stress. Furthermore, it’s a supplement, meaning that you’ll be able to provide it to your dog even if they are completely healthy. Through the use of the dropper, you’ll also be able to have complete control over the doses.

CBD treats are also a fantastic choice that can make your life, and your dog’s, a whole lot easier. As far as they know, they’re getting a delicious treat and you get the peace of mind in knowing that they’re getting some health benefits from it. Just like the CBD oil, these treats are natural, organic, and free from THC, so they’re perfectly safe for your dog.

Cushing’s Disease In Dogs: A Final Thought

When you want to make giving a supplement to your dog even easier, these soft chews are delicious, safe, and easy to dose out however you’d like. Keep in mind that with any new CBD product, it’s best to start with a very small amount and gradually increase the dose to whatever is recommended for your dog. That way, they don’t overdo it when they’re suddenly feeling great!

Now, you have a better idea of what Cushing’s is, and how to pick out the Cushing’s Disease Symptoms in dogs when they show up.

It’s not always easy to tell when your dog isn’t feeling well. Sometimes, an illness can become quite bad before you realize something is wrong.

In most cases, this is because our pets are fantastic at hiding pain. Unlike humans, they can’t really tell us when something is uncomfortable. Because of this, it’s so important to make sure you can tell when they’re behaving a little bit differently.

On top of that, getting your dog to the vet as soon as you notice any abnormalities is going to allow the vet to make a diagnosis a lot sooner, typically resulting in a much better prognosis for your furry family member. Don’t forget that in the majority of cases, Cushing’s Disease is very manageable.

We know how hard it can be to receive a diagnosis like Cushing’s for your pet. However, they still have a good chance of living a happy, long life as long as the disease is managed well. For dogs, Cushing’s Disease is certainly not a death sentence in the vast majority of cases, and you have options for helping your dog to keep living happily!

CBD for Cushing’s Disease in Dogs

Cushing’s Disease in Dogs: Are there natural alternatives? If your pet has been diagnosed with Cushing’s Disease, or if you think that your pet may have Cushing’s, you’re in the right place.

When something is going on with your pet, it can be overwhelming to figure out the issue and get a diagnosis. It can be even more confusing to know how to treat it and keep your pet feeling their best. We’re here to help.

Table of Contents

What is Cushing’s Disease in Dogs?

Cushing’s Disease is an endocrine disorder, and is also known as hypercortisolism or hyperadrenocorticism. It causes your dog’s body to make too much of a hormone called cortisol. Cortisol is a hormone that helps control stress, weight, infections, and blood sugar. Too much cortisol, or too little, can wreak havoc on your pet’s overall wellbeing.

Cushing’s Disease in dogs usually occurs in middle-aged or older dogs. There are three types of Cushing’s Disease in dogs:

  • Pituitary Dependent Cushing’s – Caused by a tumor on the pituitary gland, and is the most common type, occurring in 80-90% of animals with Cushing’s Disease.
  • Adrenal Dependent Cushing’s – Caused by a tumor on the adrenal glands, and is the second most common, occurring in about 15% of animals with Cushing’s.
  • Iatrogenic Cushing’s Syndrome – Caused by over-prescription of steroids, and is the least common type of Cushing’s.

What are the Symptoms of Cushing’s Disease in Dogs?

Many of the symptoms of Cushing’s Disease in dogs mimic the signs of aging, making them harder to identify. Symptoms of Cushing’s Disease in dogs include:

  • Being thirstier than usual
  • Excessive hunger
  • Excessive urination and more indoor accidents
  • Thinning skin
  • Excessive panting
  • Hair loss or hair growing more slowly
  • Gaining a pot belly
  • Seeming more tired or inactive
  • Getting skin infections or skin growths often

Is Cushing’s Disease in Dogs Common?

Cushing’s Disease in dogs is fairly common, particularly in older dogs.

Cushing’s is more common in certain breeds of dog . Dog breeds prone to Cushing’s Disease include: Beagles, Boston Terriers, Boxers, Dachshunds, German Shepherds, Golden Retrievers, Labrador Retrievers, Poodles, and Terriers in general.

Diagnosing Cushing’s Disease in dogs can be a struggle and dogs are often misdiagnosed. If you suspect your dog has Cushing’s Disease, your veterinarian can do a blood test, an ACTH Stimulation Test, or a Cortisol-Creatinine Ratio Test. These tests will look for cortisol levels in the blood and urine, and are often used in conjunction with an ultrasound to make the final diagnosis.

CBD for Cushing’s Disease in Dogs

The traditional treatment for Cushing’s Disease in dogs are certain hormone-regulating medications such as trilostane or mitotane. In certain cases, veterinarians may elect to go the route of surgery, which can be invasive and dangerous, especially in older dogs.

Instead, natural alternatives can help your pet without the stress of surgery or liver-damaging medications.

Full spectrum CBD oil can help treat Cushing’s Disease in dogs by modulating the hormonal imbalance, as well as shrinking, or even eliminating, the tumors causing the issue.

Primary potential benefits of using CBD for Cushing’s Disease in dogs:

  • Targeting the tumors: Cancer cells do not die on their own; continuously spreading unless we do something to stop them. CBD was found to trigger apoptosis (natural cell death) in cancer cells. CBD also reduces the growth of tumors by preventing the formation of blood vessels that feed the tumor.
  • Repairing hormonal imbalances: CBD works with the body’s endocannabinoid system to bring the body back to balance. This includes hormonal imbalances like the cortisol imbalance from the adrenal or pituitary glands.
  • Relieving the symptoms: As CBD works with the endocannabinoid system to bring the body back to a balanced state, symptoms will naturally improve.

Administering CBD for Cushing’s Disease in Dogs

The most effective way to administer a full-spectrum CBD oil for Cushing’s Disease in dogs is through an oral tincture. Look for a Full-spectrum hemp extract with a high number of cannabinoids and active CBD. We recommend our HEAL: CBD Oil for dogs , which is an 1100mg Full Spectrum Hemp Extract.

Despite common misconceptions, dosing has very little to do with your pet’s size or weight. Finding the right dosage depends on your pet’s age and metabolism, their specific ailment, and other individual health factors.

Based on research and our experience, we recommend starting with 35-50 mg daily to treat Cushing’s Disease in dogs. Within that range we recommend you start low and adjust based on your pet’s response to determine your optimal dose. You may also find that your pet needs less as they recover over time.

For the fastest and best absorption, lift the lip and apply the dosage directly onto the gums. This is the most direct way into the bloodstream. You can also add it to food, but it can take significantly longer (30-45 minutes) to reach the bloodstream, as it works its way through the gastrointestinal system.

If Cushing’s Disease in your dog has also caused skin growths, you can also apply a topical Full-Spectrum Hemp CBD salve directly to the growth. Because dogs have endocannabinoid receptors in all three layers of their skin, topical CBD salves are extremely effective. We recommend REMEDY, our 300mg Full-Spectrum Hemp CBD Salve, to be applied twice a day until the growth is gone.

Research on CBD for Cushing’s Disease in Dogs

In a research study conducted by the A.B. Hancock Jr. Memorial Laboratory for Cancer Research, Vanderbilt Institute of Chemical Biology, Vanderbilt Ingram Comprehensive Cancer Center, and Vanderbilt University School of Medicine. In the study, researchers concluded that the effects of CBD are promising in the treatment of cancer and tumors.

Another recent study found that CBD inhibited the growth of cancerous cells in mice, as well as preventing future tumors. The conclusion of this study noted that CBD could be a viable option to treat tumors in both humans and animals.

Yet another research study conducted by the Department of Physiology, School of Medicine, at Southern Illinois University. There researchers found that CBD could have profound effects on the release of hormones, including cortisol.

Case Study: CBD for Cushing’s Disease in Dogs

Meet Potato! Potato is a 15-year-old Shih Tzu who came to Fire Flake Farm with many medical issues, including Cushing’s Disease. Potato’s owner was overwhelmed and unsure of how to best help Potato.

Potato was having mobility issues, joint pain, and more. When we groomed her, we found wart-like growths all over her body. We gave her a full-dose of HEAL – CBD Oil in the morning and evening. We also applied our R EMEDY salve on her growths each day. Now, she is doing well, running around, upbeat, and acting younger than ever.

About Angela Ardolino

Angela Ardolino is a holistic pet expert who has been caring for animals for over 20 years. She operates a rescue farm, Fire Flake Farm, in Florida. She is also the owner of Beautify the Beast, a natural pet salon and shop. After getting her certificate in Medical Cannabis Biology and Therapeutic use from the University of Vermont School of Medicine, she founded CBD Dog Health . Her mission is to provide high quality, all-natural medical cannabis products designed specifically for pets.