best cbd oil for liver damage

CBD For Liver Disease (NAFLD & AFLD): What the Research Says

Studies have shown that people who regularly use cannabis have fewer incidences of fatty liver disease.

How does this work?

Can CBD oil support people with liver disease?

Article By

Fatty liver disease is a serious, but common medical condition.

Some studies have shown it to be present in about 16% of the population [1].

It’s a problem that tends to get worse until, eventually, it results in liver failure.

There are currently no known cures for the disease, however, recent evidence has suggested that CBD can be extremely beneficial for the condition.

Here, we investigate these claims, how they may work, and how CBD oil can be used to support fatty liver disease.

MEDICALLY REVIEWED BY

Updated on June 05, 2021

Table of Contents
Recommended products
$49 – $229
Royal CBD
Royal CBD Oil 30 mL

5 / 5

Total CBD: 500 – 2500 mg
Potency: 16.6 – 83.3 mg/mL
Cost per mg CBD: $0.12 – $0.18
Extract Type: Full-spectrum
THC Content: <0.3%

The Benefits of CBD Oil For Fatty Liver Disease

CBD oil has indirect benefits for fatty liver disease. Research has shown CBD protects the liver by preventing overreaction of the endocannabinoid system (ECS). When the liver becomes stressed (due to poor diet or exposure to toxic compounds), the endocannabinoid system becomes highly active in the liver.

It’s this activation of the ECS leads to a buildup of fatty acid particles in the liver. CBD may prevent this from happening and may help slow the progression of the disease.

The only way to effectively treat fatty liver disease is through diet and lifestyle modifications. CBD oil can help support the condition, but won’t offer a cure.

The Best CBD Oils For Fatty Liver Disease

Guide to Using CBD Oil For Fatty Liver Disease

In recent years, there’s been a lot of reports that marijuana users suffered less frequently from obesity, diabetes, and metabolic syndrome [3-5], all of which are key drivers of fatty liver disease.

This is even more interesting when these researchers began looking at the diets of cannabis users and non-users.

On average, cannabis users ate more junk foods, soda, and alcohol than non-users [6], yet still had lower incidences of metabolic disease.

So this had researchers wondering;

“Could marijuana and CBD oil be used to prevent or treat fatty liver disease?”

A large research study analyzed the effects of CBD on 22,366 patients, many of which had active fatty liver disease or earlier stages of metabolic syndrome. Researchers in this study confirmed that the chances of developing fatty liver disease were much lower in those who were active cannabis users, though they were unable to suggest a mechanism for these effects [7].

Other studies have since been published that shed some light on how this works.

In order to get into the details of how this works, let’s discuss the role of the endocannabinoid system in the liver, and how this plays an important role in fatty liver disease.

What’s The Dose of CBD Oil For Fatty Liver Disease?

Dosing CBD for fatty liver disease is very similar to dosing it for other conditions.

Because the cannabinoids affect everybody so differently, it’s recommended that you always start with a lower dose (around 1 mg per day) and increase gradually from there.

Some people will stay at this 1 mg dose, while others may need substantially more, perhaps around the 30 mg mark,

The best way to find out the dose for you is to take 1 mg, then increase by 4 mg each day.

If side effects are noted (such as drowsiness, nausea, or poor appetite) simply reduce the dose to the last one that produced no side effects and stay there.

Fatty liver disease is a long-term, chronic condition, and will, therefore, need to be taken over a long period of time.

We recommend taking a high-quality CBD oil for 6 or 12 months, with regular follow-ups with your doctor to see any progression.

CBD Oil Dosage Calculator

Embed this map on your site

Copy and paste the code below

What is Fatty Liver Disease?

Fatty liver disease is exactly what it sounds like: fat deposits in the liver.

When this happens, the fat deposits will start to interfere with the liver’s ability to function. If left unchecked, it will eventually lead to much more serious health problems.

There are two types of fatty liver disease:

1. Non Alcoholic Fatty Liver Disease (NAFLD)

Non-alcoholic fatty liver disease is caused by metabolic dysfunctions in the body.

Our liver plays a major role in the regulation of both sugar and fat metabolism.

The liver teams up with the pancreas and adrenal glands to control our blood sugar levels and fat burning or storage.

When we eat too much sugar or refined carbohydrates like chips, white bread, or candy, and don’t exercise enough, our body stops listening to one of the hormones secreted by the pancreas — insulin.

This is the starting point for fatty liver disease.

As soon as insulin stops working, the body no longer uses sugar the way it’s supposed to, causing it to build up to dangerous levels in the blood.

The liver needs to work much harder to stop the build-up of sugar from causing damage to the body. It does this by converting the sugar into stored fat.

When this happens, fat droplets accumulate inside the liver cells themselves.

Over time, these fat droplets will grow and take up more and more space inside the liver.

This causes damage to the liver cells, making them less effective at doing the job they’re meant to do. As the liver cells die, they trigger inflammation in the area, causing the liver to swell and become even less effective.

With long-term inflammation, the liver will begin to fill up with scar tissue, known as fibrosis.

These scars cause permanent changes to the liver, making it ineffective, and eventually leading to more serious symptoms.

NAFLD is driven by poor diet and lack of exercise.

2. Alcoholic Fatty Liver Disease (AFLD)

Alcoholic fatty liver is caused by long-term alcoholism.

The body can generally tolerate small amounts of alcohol relatively well, however, large amounts are problematic to the body.

There are 3 different ways the liver can metabolize alcohol, the main one being a pathway called alcohol dehydrogenase. There are many steps to this process, but the most important thing to know is that it requires a lot of energy to function.

This energy comes in the form of something called NAD+.

NAD+ can be thought of as a cellular currency for energy.

In order for the liver to get access to enough NAD+ to fuel alcohol metabolism, it needs to build a lot of fat. This is because NAD+ is a byproduct of building fat.

This leads to a buildup of fatty acids in the liver.

Over long periods of time, this fat can build-up to the point where it starts to get in the way, no matter where the liver tries to put it. There is simply too much.

By the time fatty liver disease symptoms show up in an alcoholic, there’s already a great deal of damage done, and it’s very difficult to repair, even with CBD oil.

CBD oil is best used for people with non-alcoholic fatty liver disease, so this is going to be the main focus of this article.

Diet & Lifestyle Modifications

As you can see, both alcoholic and non-alcoholic fatty liver disease is caused primarily by lifestyle and diet factors.

Diets with too much sugar or refined carbohydrates, poor exercise, and excessive alcohol intake are all key drivers in the condition.

Therefore, anything you take to help the condition is going to come secondary to changing the causes. This means visiting a holistic nutritionist, or dietitian, and working on changing your habits around food and alcohol.

CBD oil can go a long way if used in combination with these changes but will do very little on its own.

The Endocannabinoid System & Fatty Liver Disease

The endocannabinoid system is found in all mammals.

It’s a system of receptors (CB1 and CB2 receptors) and endogenous cannabinoids that are responsible for regulating many of our homeostatic control mechanisms.

In simple English, this means that the endocannabinoid system controls the balance of various systems in the body.

When our organs become damaged, inflamed, or dysfunctional, we find a noticeable increase in the endocannabinoid activity in the area, as it tries to bring us back to normal levels.

In a healthy liver, the endocannabinoid system only has a modest presence. In fact, it doesn’t appear to do much at all in this particular organ.

However, when the liver becomes damaged and inflamed, the endocannabinoid system wakes up and starts to be very active in the area.

Too active, perhaps…

When fatty liver starts and the liver function begins to suffer, the endocannabinoid system steps up to try and make things normal again, unfortunately, it only appears to make things worse, and CB1 and CB2 endocannabinoid receptors play a role in the development of fatty liver disease [8].

Supporting Liver Function With CBD

This is going to get real confusing, so let me get this out of the way.

CBD is a CB1 and CB2 receptor agonist-antagonist.

What does this mean, you ask?

In this case, it means that CBD stops the compounds that are making the endocannabinoid receptors (CB1 and CB2) in the liver go haywire.

It stops the endocannabinoid system from going crazy, establishing balance to the endocannabinoid system itself.

It’s the equalizer for the system that balances us.

This effectively protects the body from things like fatty liver disease and makes it easier for us to resist and recover from this condition more effectively.

It’s important to note that this action alone isn’t going to prevent fatty liver disease, but will make it more difficult for the condition to occur, giving us more time to change our lifestyle habits and diet before any permanent consequences set in.

Key Takeaways: Can CBD Oil Help With Fatty Liver Disease?

The best way to prevent or treat fatty liver disease is through diet modification.

CBD and other cannabinoids are going to go a long way in slowing the progression of the disease, and may even help to reverse it, but they aren’t going to work very well if the causes are still going on.

The primary cause of fatty liver disease is poor diet and lifestyle habits.

Heavy drinking, high junk food diets, and lack of exercise are the main causes of the condition. If they aren’t removed, the problem will persist and eventually get worse.

Combining CBD oil with diet changes – like eliminating processed and refined carbohydrates -, quitting alcohol or cigarette consumption, and spending at least 30 minutes per day on a mild-moderate level of exercise are going to go a long way in addressing the actual cause for the condition.

Best CBD Oil for Liver Damage – March 2022

Liver damage treatment depends on the underlying condition. Some liver problems can be remedied with lifestyle modifications, such as losing weight or stopping alcohol. Some may require treatment or surgery (5) . Diuretics and lactulose are the most common treatments for advanced liver disease, called cirrhosis.

Medication for autoimmune liver damage often involves corticosteroids. Treatments, such as prednisone, may cause side effects, such as glaucoma, weight gain, high blood pressure, and mood swings (6) .

Moreover, surgery or a liver transplant may result in several complications, such as infection, bleeding, seizures, failure, or rejection of the donated liver (7) . However, the benefits of a liver transplant are generally greater than the risks and it is potentially lifesaving.

The side effects of these treatments have caused individuals to look for a supplemental approach to treating their livers.

Moreover, some individuals with liver conditions that cannot be treated with pharmaceutical drugs are also on the lookout to reclaim their health.

CBD is becoming a popular alternative for many health problems. However, there are still many questions about whether CBD can help with liver damage or not.

While some studies have acknowledged CBD’s potential ability to stimulate liver regeneration through in vitro and vivo experiments, there are studies that link CBD to liver damage in animal subjects.

CBD vs. Hepatitis C

Hepatitis C is a liver condition caused by the hepatitis C virus (HCV). There is currently no vaccine for this infection. Infected individuals may experience fever, fatigue, loss of appetite, joint pain, and jaundice.

In 2019, the World Health Organization (WHO) estimated that there were new 1.25 million HCV infections worldwide (8) .

An in vitro study found that CBD might have bioactivities against HCV. The study added that CBD’s direct antiviral activity indicated that it might be effective against viral and nonviral hepatitis (autoimmune hepatitis) (9) .

Although the study showed promising results of CBD against HCV, it was also noted that CBD did not affect the hepatitis B virus (10) .

Individuals must consult a physician before considering the use of CBD for hepatitis C. Untreated hepatitis C may lead to long-term infection known as chronic hepatitis C, which may result in severe liver damage (11) . Also, now there are other safe, effective treatments for Hepatitis C available.

CBD vs. Alcoholic Liver Disease

Alcoholism can induce hepatosteatosis (fatty liver disease), commonly known as alcoholic liver disease (ALD).

With early detection and lifestyle change, ALD is reversible. If left untreated, however, this can later progress to severe liver problems, such as cirrhosis and hepatitis.

Researchers found that oxidative stress is one of the primary factors in inducing steatosis. A study demonstrated that CBD reduced ethanol-induced liver injury on animal subjects by reducing oxidative stress (12) .

Moreover, the study observed how CBD stimulated autophagy (removal of damaged liver cells) during in vitro and vivo experiments.

The study noted how all these mechanisms might be essential for alleviating steatosis.

CBD vs. Non-alcoholic Fatty Liver Disease

As the name implies, non-alcoholic fatty liver disease (NALD) is a condition concerning individuals who consume little to no alcohol. It is caused by excess fat accumulation in the liver.

  • Overweight or obesity
  • Insulin resistance
  • High levels of triglycerides (fat) in the body
  • High blood sugar

Management of NAFLD may be challenging since no prescription treatment has been approved for the condition (13) . Health experts will recommend a change in lifestyle and diet habits to lose weight and reverse the fat deposition.

A study posted on Hepatology mentioned that high-fat diets might result in elevated leptin levels and plasma insulin.

The increase in glucose levels is often accompanied by hyperglycemia, indicating that the body is insulin resistant (14) .

Many scientists have tested CBD’s efficacy for weight loss. A recent study posted in the Frontiers in Endocrinology mentioned the positive influence of CBD on the liver.

The administration of CBD reduced intracellular lipid (fat) content in an in vitro hepatosteatosis model. The review also acknowledged the antioxidant and anti-inflammatory properties of CBD (15) .

Moreover, a 2017 study published by Plos One conducted a study on cannabis users and found a strong relationship between cannabis use and reduced prevalence of NAFLD (16) .

More clinical studies are needed to verify CBD’s efficacy in reducing lipid content in the liver and its anti-obesity properties.

How CBD Oil Works to Help With Liver Damage

The human endocannabinoid system (ECS) is composed of G-protein-coupled receptors, such as the cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2).

CB1 receptors are located throughout the body. The majority of them are located in the central nervous system. CB2 receptors can be found primarily in the immune system (17) .

The endocannabinoid system has been studied for decades for its role in modulating various physiological functions and peripheral organs.

Modulating the ECS activity might have several therapeutic responses to health conditions and diseases (18) .

A study released in Pharmacological Reviews mentioned evidence indicating the role of the ECS in the control of gastrointestinal motility and secretion.

The authors in the study further expounded how the ECS can influence appetite, energy, weight balance, and metabolism. They f ound that administering a CB1 antagonist reduced food intake and body weight among animal test subjects.

The study also mentioned that CB1 receptor knockout mice treated with CB1 antagonists were resistant to diet-induced obesity (DIO) (19) .

Another study posted in the International Journal of Molecular Sciences discussed how CB1 antagonists reduced obesity in DIO mice (20) .

The role of the CB2 receptor was discussed by a study published in Hepatology . This study tested how the CB2 receptor agonist improved fibrogenesis and accelerated liver regeneration (21) .

The British Journal of Pharmacology posted a study that explained how CBD might have the ability to behave as a CB2 receptor inverse agonist, which may contribute to anti-inflammatory properties (22) .

The British Journal of Pharmacology also published a study that explained how CBD might work as both cannabinoid receptor agonists and antagonists. The study mentioned how CBD, in low doses, might act as CB1 antagonist (23) .

This is supported by an independent 2019 study published in the Canadian Journal of Kidney Health and Disease. In the study, the scientists used CBD to block CB1 receptors of insulin-resistant rats, preventing proteinuria and renal function decline. This study has shown that CBD can act as a CB1 antagonist (24) .

The study from the British Journal of Pharmacology further explained that CBD might behave as a CB2 receptor antagonist and inhibit immune cell migration and reduce signs of inflammation (25) .

Moreover, CBD has been shown to stimulate CB2 receptors during an in vitro study. This interaction resulted in the proliferation of T-cells and macrophages responsible for the release of inflammatory cytokines that cause autoimmune hepatitis (26) .

Pros and Cons of CBD Oil for Liver Damage

The Pros
  • CBD might improve symptoms of acute liver failure, thus serving as a potential therapeutic agent for treating human hepatic encephalopathy (27) .
  • During an in vitro study, CBD displayed bioactivities against the hepatitis C virus. CBD’s direct antiviral activity indicated that it might be useful against viral and nonviral hepatitis (28) .
  • A study has shown that CBD might be useful in reducing alcohol liver injury by reducing oxidative stress (29) .
  • An in vitro study demonstrated how CBD reduced intracellular lipid content in the fatty liver model (30) .
  • CBD might have antioxidant and anti-inflammatory properties that could help maintain homeostasis in the liver (31) . However, very high doses could cause liver damage.
  • Liver damage caused by high-dose CBD is generally reversible when CBD or other medications are reduced or stopped altogether according to the FDA studies on Epidiolex.
  • Many distinguished health agencies, including the World Health Organization (WHO), stated that CBD is generally well-tolerated and safe (32) .
  • Prescriptions are not needed when buying CBD oil.
The Cons
  • According to the U.S. Food and Drug Administration (FDA), CBD in high doses can lead to liver injury (33) .
  • The CBD industry remains unregulated. Individuals should research product specifications, third-party laboratory tests, testimonials, and reviews.
  • CBD might have several drug interactions with other medications. Always consult a physician before taking CBD. Liver disease is serious and treatment should always be medically supervised.
  • CBD cannot treat, prevent, cure, diagnose, or mitigate any disease other than certain rare childhood seizures.

How Does CBD Compare to Other Alternative Treatments?

There are several herbal treatments available for individuals who want to treat their liver conditions naturally. However, health experts have discovered that these may also cause harm if caution is not exercised (34) .

Sho-saiko-to is an herbal medicine used for chronic hepatitis in China and Japan. Its use as an oriental classical medicine was first introduced 1500 years ago.

Various clinical studies suggested t hat Sho-saiko-to might help protect against the development of hepatocellular carcinoma among individuals with cirrhosis. However, the mechanism for this remains unclear (35) .

The Ministry of Health and Welfare in Japan, who had approved Sho-saiko-to as a treatment for liver disease, had to revisit the efficacy of the herb as it caused adverse respiratory effects among patients, resulting in 10 deaths (36) .

Silymarin (milk thistle) is another natural herb that is used to treat liver and biliary disorders. The oldest reported use of Silymarin dates back to the ancient Greeks and Roman period when people used the plant to treat snake bites and liver conditions (37) .

Holy basil is another plant that is believed to have hepatoprotective properties. The plant contains phytochemicals that have analgesic and anti-inflammation properties (38) .

Like most of the herbal treatments mentioned, CBD is also a natural compound derived from Cannabis sativa (hemp). The use of cannabis sativa started during the medieval Islamic period when physicians used the plant to treat various conditions (39) .

A study has shown how CBD restored liver and brain function among animal subjects with induced-hepatic failure. The study also acknowledged the anti-inflammation and antioxidant properties of CBD, which could help in maintaining homeostasis in the liver (40) .

How to Choose the Right CBD Oil for Liver Damage

CBD oil comes in three types of concentrations.

Full-spectrum CBD oil contains all the cannabinoids present in hemp , such as cannabidiol (CBD), cannabigerol (CBG), cannabinol (CBN), and tetrahydrocannabinol (THC).

THC is the cannabinoid known for producing psychoactive effects. In a full-spectrum CBD concentrate, THC levels cannot exceed the U.S. legal limit of 0.3%.

Many studies have shown that THC may also have some hepatoprotection properties.

A study published in Hepatology found that THC attenuated the progression of autoimmune hepatitis in animal subjects. Results indicated the decreased plasma levels of liver enzymes, inflammatory cytokines, and reduced tissue injury (41) .

For individuals who want the benefits of all the cannabinoids present in hemp, full-spectrum CBD oil is the best option.

Although the full-spectrum concentrate has very low THC, some individuals prefer not to have THC in their system due to work and other personal reasons. Therefore, their next option can be broad-spectrum.

Broad-spectrum CBD oil contains all the cannabinoids present in hemp, except for THC.

Lastly, CBD isolate is a concentrate made especially for individuals who want to take CBD into their system. CBD isolates may be good for people who want CBD without the presence of carrier oils and other cannabinoids.

Since individuals with liver problems may be vulnerable to many substances and compounds, it is advisable to do extensive research before choosing a CBD brand.

The certificate of analysis (COA) is a third-party lab result presented by legitimate CBD brands who want to assure their customers that their concentrations are the same as what they advertise.

The COA also indicates that the extract is free from harmful chemicals, such as heavy metals, pesticides, and other contaminants. Moreover, the COA specifies the extraction process used for the CBD oil concentration.

For individuals with liver problems, it is recommended that they choose CBD oil with CO2-extraction. This is a method that does not use any solvents.

  • Vaping enthusiasts should choose a CBD brand that does not use fillers and other toxic substances, like propylene glycol and polyethylene glycol. CBD vapes that contain nicotine are also harmful.
  • The carrier oil may be an essential factor to consider due to allergy, intolerance, and liver safety issues. Carrier oils can be hempseed oil, MCT (unrefined coconut oil), grapeseed oil, sunflower oil, or avocado oil.
  • Choose non-GMO organic hemp. This is usually specified by the brand.
  • Do some additional research by reading testimonials and recommendations from other customers.
  • Remember that CBD can cause liver damage in very high doses

It is strongly recommended that individuals suffering from mild to severe liver damage consult a hepatologist before adding CBD to their daily regimen.

Discussing the formulation and ingredients used with your physician may be crucial for one’s liver health. Never attempt to diagnose or treat yourself.

CBD Dosage for Liver Damage

There is currently no universal dosage recommended for CBD users. However, it is recommended that one starts with a low dose.

A 2019 study released in the British Journal of Pharmacology recommended that CBD be taken from less than 1 to 50 milligram per kilogram a day (42) . Once the system gets used to CBD, the dosage may be increased.

One must also use discretion when using CBD and always discuss their dosage with physicians. CBD may cause liver injury when used in high dosages (43) .

How to Take CBD Oil for Liver Damage

The most recommended approach to taking CBD for liver damage is through CBD tinctures. One can use a dropper to put CBD oil under the tongue.

CBD vape is another option to consider for individuals who do not want to take CBD oil orally. Some experts consider vaping to be a more effective and faster mode of delivery (44) .

However, one must make sure that the CBD oil or cartridge does not contain harmful chemicals that can further damage the liver (45) .

Can CBD Oil Cause Liver Damage?

Epidiolex is the first FDA-approved medication that contains CBD oil. It is primarily used for children with rare forms of epilepsy. However, Epidiolex in doses higher than the recommended 10-20 milligram per kilogram per day may cause liver injury (46) .

The University of Arkansas for Medical Sciences posted a review in 2019 that showed how higher doses of CBD oil on 8-week old mice models led to liver toxicity (47) . Molecules published this study, followed by Forbes and other media entities.

The dosage amounts used in the study were 246mg/kg, 738mg/kg, and 2460mg/kg. The study later observed that a single dose of 2460 mg/kg exhibited hepatotoxicity and increased bilirubin. They also added that a similar response was observed among monkeys injected with lethal CBD doses.

The authors explained that the purpose of this experiment was to study the potential effects of lethal doses of CBD among living organisms. They added that the dosage that produced fatal results in the study does not apply to real-life scenarios (48) .

The authors also mentioned that more studies are needed to determine the consequences of prolonged use of CBD.

Another thing to note in the study is that scientists used hexane as the extraction solvent for their CBD concentrate. Hexane is a chemical made from crude oil and is a potentially toxic compound when used on animals and humans (49) .

Most CBD oil manufacturers use three extraction methods, such as hydrocarbon extraction, ethanol extraction, and CO2-extraction. The extraction method should be indicated in the certificate of analysis (COA).

Individuals are advised to always research the brand properly before purchasing. The COA is crucial in determining if the CBD concentrate is safe and free from harmful chemicals.

Conclusion

Studies have shown that CBD might have hepatoprotection properties. It has been indicated that CBD can reduce lipid content and reduce oxidative stress in alcoholic liver injury (50) .

It has also been shown that CBD might have bioactivities against the hepatitis C virus (51) . Lastly, a study has shown that CBD might potentially restore liver function during hepatic encephalopathy (52) .

Best CBD Oil for Liver Disease

Although some liver conditions may be managed with lifestyle modifications, more severe conditions may need a different remedy. If you are considering using cannabidiol ( CBD ), CBD Clinicals may help you find the right product you need to help maintain a healthier liver.

Spruce 750mg Lab Grade CBD Oil
  1. Peppermint flavor masks any unpleasant taste
  2. Contains 25mg of CBD per dropper full
  3. Bottle includes a graduated dropper for correct serving measurement

View Latest Prices

Best CBD Purity

NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
  1. Natural remedy for various illnesses
  2. Product is full-spectrum whole-plant extract
  3. Contains naturally occurring synergistic cannabinoids and terpenes

View Latest Prices

Best High Potency

Spruce 2400mg Lab Grade CBD Oil
  1. Maximum possible potency
  2. Each dropper full contains 80mg of CBD
  3. Conveniently fits in a 30mL bottle

View Latest Prices

Avida Full Spectrum CBD Oil Tincture 500mg
  1. Proprietary full-spectrum
  2. Developed using advanced AVIDA CORE Spectrum Technology
  3. Highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3)

View Latest Prices

cbdMD CBD Oil Tincture Natural 1500mg
  1. made using only CBD sourced from medical hemp
  2. available in many flavours
  3. safe for daily use

View Latest Prices

CBDistillery THC Free CBD Oil Tinctures
  1. Do not contain THC
  2. Available in different potencies and sizes
  3. Brand has special deals and offers

View Latest Prices

Best Customer Rated

cbdMD CBD Oil Tincture Natural 750mg
  1. THC-free
  2. Has plenty of flavours to choose from
  3. Totally vegan

View Latest Prices

Best For Beginners

NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
  1. Lowest concentration for CBD beginners
  2. Fully organic and lab-tested
  3. Full-spectrum

View Latest Prices

Best Flavor Range

Hemp Bombs 750mg CBD Oil
  1. Has a wide range of flavours
  2. Safe to intake
  3. Get 20% off when you avail of their subscription

View Latest Prices

Best CBD Oil for Liver Disease 2022

    Editor’s Pick Best Organic Editor’s Pick Best Seller Best Natural Alternative Best THC-Free Best Customer Rated Best Starter Best Flavor Range

Compare the Best CBD Oil for Liver Disease in 2021

Best CBD Oil for Liver Disease

1. Spruce 750mg Lab Grade CBD Oil
cbdc overall score
CBDC Evaluation Table/Score
Overview

Each bottle of the 750mg CBD oil tincture contains 25mg of CBD per dropper full. The oil is peppermint flavor to mask any unpleasant tastes related to CBD.

2. NuLeaf Naturals 900mg Full Spectrum Hemp CBD Oil
cbdc overall score
CBDC Evaluation Table/Score
Overview

Natural remedy for various illnesses. NuLeaf Naturals’ CBD oil is a whole-plant extract containing a full spectrum of naturally occurring synergistic cannabinoids and terpenes.

3. Spruce 2400mg Lab Grade CBD Oil
cbdc overall score
CBDC Evaluation Table/Score
Overview

The largest bottle of CBD oil that Spruce offers contains 2,400mg of CBD. This is full-spectrum CBD oil, which is the maximum possible potency. Each high potency dropper full contains 80mg of CBD. There are no flavorings in it, which allows for the most CBD to fit in the 30ml bottle.

4. Avida Full Spectrum CBD Oil Tincture 500mg
cbdc overall score
CBDC Evaluation Table/Score
Overview

Avida Extracts Full Spectrum CBD oil is the latest iteration of the brand’s advanced Avida CORE Spectrum technology. They use a proprietary full spectrum blend, resulting in the highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3) to support your health.

5. cbdMD CBD Oil Tincture Natural 1500mg
cbdc overall score
CBDC Evaluation Table/Score
Overview

cbdMD’s CBD oil tinctures are made using only CBD sourced from medical hemp and MCT oil as a carrier oil. Tinctures are offered in orange, mint, natural, and berry flavors. Safe for daily use, the oil tinctures are packaged with a built-in rubber dropper to adjust CBD dosage easily. The packaging is made to be easy to transport and discreet to use.

6. CBDistillery THC Free CBD Oil Tinctures
cbdc overall score
CBDC Evaluation Table/Score
Overview

CBDistillery’s Isolate CBD Oil Tinctures harness the power of pure CBD. CBD Isolate Oil Tinctures include 0.0% THC. When you use CBDistillery CBD Isolate Oil Tinctures, you can be assured you’re using the highest quality CBD on the market.

7. NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
cbdc overall score
CBDC Evaluation Table/Score
Overview

This is one of several concentrations from NuLeaf Naturals. As the lowest concentration, it is the company’s best option for those new to CBD oil. The product is lab-tested and fully organic. It is full-spectrum, so it contains THC in small quantities.

8. cbdMD CBD Oil Tincture Natural 750mg
cbdc overall score
CBDC Evaluation Table/Score
Overview

A 750mg bottle of cbdMD’s Broad Spectrum Oil Tincture does not contain THC. It also has a fairly wide flavor range which is perfect for those who prefer other taste. Vegan consumers are considered since cbdMD offers Vegan products. Aside from all of that, another reason why people love cbdMD is because it’s free from harmful chemicals.

9. Hemp Bombs 750mg CBD Oil
cbdc overall score
CBDC Evaluation Table/Score
Overview

Hemp Bombs offer CBD Oil Tinctures that come in a 30ml bottle containing 750mg of CBD. They provide a wide range of flavors perfect for those that have a knack for sweets. Consumers can safely intake this because it’s free of chemicals and pesticides. Hemp Bombs also offer a 20% off on products upon subscription.

How We Rank
Our Ratings

How Do We Rank Our Reviews?

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Cras molestie elementum elit, et tincidunt nulla luctus malesuada. Pellentesque quis purus a ipsum congue varius semper id lectus. Fusce tempor lacinia egestas. Fusce sit amet lectus molestie magna suscipit porta. Pellentesque magna leo, condimentum ut felis in, feugiat congue ligula. Aliquam nibh dui, venenatis sed nibh id, dictum viverra diam. Morbi ac tristique neque.

Value

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Cras molestie elementum elit, et tincidunt nulla luctus malesuada. Pellentesque quis purus a ipsum congue varius semper id lectus. Fusce tempor lacinia egestas. Fusce sit amet lectus molestie magna suscipit porta. Pellentesque magna leo, condimentum ut felis in, feugiat congue ligula. Aliquam nibh dui, venenatis sed nibh id, dictum viverra diam. Morbi ac tristique neque.

Core Technology

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Cras molestie elementum elit, et tincidunt nulla luctus malesuada. Pellentesque quis purus a ipsum congue varius semper id lectus. Fusce tempor lacinia egestas. Fusce sit amet lectus molestie magna suscipit porta. Pellentesque magna leo, condimentum ut felis in, feugiat congue ligula. Aliquam nibh dui, venenatis sed nibh id, dictum viverra diam. Morbi ac tristique neque.

Expandable Packages

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Cras molestie elementum elit, et tincidunt nulla luctus malesuada. Pellentesque quis purus a ipsum congue varius semper id lectus. Fusce tempor lacinia egestas. Fusce sit amet lectus molestie magna suscipit porta. Pellentesque magna leo, condimentum ut felis in, feugiat congue ligula. Aliquam nibh dui, venenatis sed nibh id, dictum viverra diam. Morbi ac tristique neque.

Installation & Set-Up

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Cras molestie elementum elit, et tincidunt nulla luctus malesuada. Pellentesque quis purus a ipsum congue varius semper id lectus. Fusce tempor lacinia egestas. Fusce sit amet lectus molestie magna suscipit porta. Pellentesque magna leo, condimentum ut felis in, feugiat congue ligula. Aliquam nibh dui, venenatis sed nibh id, dictum viverra diam. Morbi ac tristique neque.

Trial Period & Flexible Contracts

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Cras molestie elementum elit, et tincidunt nulla luctus malesuada. Pellentesque quis purus a ipsum congue varius semper id lectus. Fusce tempor lacinia egestas. Fusce sit amet lectus molestie magna suscipit porta. Pellentesque magna leo, condimentum ut felis in, feugiat congue ligula. Aliquam nibh dui, venenatis sed nibh id, dictum viverra diam. Morbi ac tristique neque.

Brand Recognition & Reputation

Lorem ipsum dolor sit amet, consectetur adipiscing elit. Cras molestie elementum elit, et tincidunt nulla luctus malesuada. Pellentesque quis purus a ipsum congue varius semper id lectus. Fusce tempor lacinia egestas. Fusce sit amet lectus molestie magna suscipit porta. Pellentesque magna leo, condimentum ut felis in, feugiat congue ligula. Aliquam nibh dui, venenatis sed nibh id, dictum viverra diam. Morbi ac tristique neque.

How CBD Helps With Liver Disease

There are several types of liver diseases caused by viruses, genes, and substance abuse. The most common liver diseases include cirrhosis , fatty liver disease , hepatitis, and hemochromatosis, a genetic condition that may be inherited (1) .

Although some liver problems may be remedied with lifestyle modifications, some conditions may require treatment or surgery (2) .

Treatment for autoimmune liver damage often includes corticosteroids or steroid hormones. Another medication for liver damage is prednisone, which may cause side effects , such as weight gain, high blood pressure, glaucoma, and mood swings (3) .

A liver transplant is a treatment option for more serious liver diseases . However, a liver transplant also comes with several complications, such as internal bleeding, infection, seizures, liver failure, or rejection of the donated organ (4) .

The drawbacks of these liver damage treatments may cause some individuals to search for more natural approach es to treating their livers. Some patients with liver conditions cannot be treated with pharmaceutical drugs, encouraging them to look for other remedies.

CBD has gained popularity because of the cannabinoid ’s potential health benefits. Cannabinoids are chemical compounds found in the cannabis plant.

However, there are still questions about whether CBD may help with liver damage or not.

Although some studies have acknowledged the cannabinoid ’s potential ability to stimulate liver regeneration, some studies link CBD to liver damage in animal subjects.

The human endocannabinoid system (ECS) is made up of G-protein-coupled receptors: the cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2).

G-protein-coupled receptors are receptors in the body that link and transmit signals from compounds to a molecule called a G-protein (5) .

You may find CB1 receptors throughout the body. However, the majority of them are in the central nervous system. Meanwhile, CB2 receptors may be found primarily in the immune system (6) .

Medical researchers have been studying the ECS for decades to manage various physiological functions and peripheral organs.

According to a 2006 study, modulating ECS activity may have several therapeutic responses to various health conditions and diseases (7) .

The researchers of the 2006 study observed how the ECS may affect weight balance, appetite, energy, and metabolism. They noted that administering a CB1 antagonist decreased food intake and body weight among animal test subjects.

Receptor agonists are medications that bind to receptors and activate them . Meanwhile, antagonists reduce the receptor’s ability to be activated (8) .

Another study found in the International Journal of Molecular Sciences noted how CB1 antagonists reduced obesity in mice with diet-induced obesity (9) .

Meanwhile, a Hepatology study observed how a CB2 receptor agonist improved fibrogenesis and accelerated liver regeneration (10) .

Findings from the British Journal of Pharmacology discussed how CBD may function as a CB2 receptor inverse agonist , producing anti-inflammatory effects (11) .

A 2008 study noted that CBD may work as both a cannabinoid receptor agonis t and antagonis t . The authors stated that CBD in low doses may act as a CB1 antagonist (12) .

The 2009 study was supported by a more recent independent study published in the Canadian Journal of Kidney Health and Disease . In the study, the medical researchers used the cannabinoid to block CB1 receptors of insulin-resistant rats, preventing proteinuria (increased protein in the urine) and renal function decline (13) .

A recent study highlighted that CBD may function as a CB1 antagonist (14) .

Benefits of Using CBD for Liver Disease

According to a 2011 animal study, CBD may restore liver function , normalize 5-HT levels, and improve brain pathology. The researchers observed that the effects of the cannabinoid may be from a combination of CBD ’s activities in the liver and brain (15) .

Meanwhile, a 2017 study demonstrated that CBD treatment significantly reduced alcohol-induced liver damage in a mouse model. The medical researchers noted that CBD may have therapeutic potential in liver disease linked with inflammation, metabolic dysregulation, oxidative stress , and steatosis (fatty change) (16) .

Below are some of the published studies about the effect s of CBD on liver diseases .

Hepatitis C

Hepatitis C is a condition caused by the hepatitis C virus (HCV). Symptoms include tiredness, fever, joint pain, loss of appetite, and jaundice (whites of the eyes turning yellow).

According to the World Health Organization (WHO), there were new 1.25 million HCV infections worldwide in 2019 (17) .

A 2017 study stated that CBD may have bioactivities against HCV. The study noted that CBD ’s direct antiviral activity may be effective against non-viral and viral hepatitis ( autoimmune hepatitis) (18) .

Although the 2017 study highlighted CBD ’s potential benefits against HCV, medical researchers also noted that the cannabinoid did not affect the hepatitis B virus.

You must consult a physician before using CBD for hepatitis C . According to Mayo Clinic, untreated hepatitis C may cause a long-term infection, such as chronic hepatitis C , resulting in severe liver damage (19) .

Alcoholic Liver Disease

Alcoholism may result in hepatosteatosis (fatty liver disease ), also known as alcoholic liver disease (ALD).

With early detection and lifestyle modifications, ALD may be treated and reversed . However, if left untreated, ALD may progress to severe liver problems, such as hepatitis and cirrhosis .

Researchers noted that oxidative stress is one of the main factors in inducing steatosis . In a 2014 animal study published in Free Radical Biology and Medicine , medical researchers reported that CBD reduced toxicity and oxidative stress , resulting in reduced ethanol-induced liver injury (20) .

In a Frontiers of Pharmacology study, animal studies showed that CBD may reduce liver steatosis and fibrosis caused by chronic and binge ethanol administrations (21) .

Non-Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NA F LD) is a medical condition caused by excess fat accumulated in the liver.

The causes of NAFLD may be obesity , insulin resistance, high levels of fat in the body, or high blood sugar.

There has been no prescription treatment approved to manage NAFLD (22) . If you have NAFLD , your doctor may recommend a change in lifestyle and diet habits to help you lose weight naturally and reverse the fat deposition.

Several medical researchers have studied CBD ’s efficacy in weight loss. A 2020 study posted in the Frontiers in Endocrinology observed the positive effects of CBD on the liver (23) .

According to the 2020 study, CBD helped reduce intracellular lipid (fat) content in an in vitro (outside a living organism) hepatosteatosis model. The study also noted that CBD had antioxidant and anti-inflammatory effects (24) .

Meanwhile, in a 2017 study published by PLOS One, medical researchers observed a strong connection between cannabis use and reduced NAFLD prevalence (25) .

However, further clinical studies are needed to verify the cannabinoid ’s efficacy in reducing lipid content in the liver and CBD ’s anti- obesity properties.

Other Benefits of CBD for Liver Disease

According to a 2011 study, CBD may help manage acute liver failure symptoms, thus serving as a potential therapeutic compound for treating human hepatic encephalopathy (brain function decline caused by severe liver disease ) (26) .

Many health agencies, including the WHO, stated that the non-psychoactive cannabinoid is safe and generally well-tolerated (27) .

P rescription is required when buying medications for liver disease . In contrast, some US states allow individuals to purchase hemp-derived CBD products even without a prescription.

Risks of Using CBD for Liver Disease

The production of CBD remains unregulated. The US Food and Drug Administration ( FDA ) has only approved Epidiolex , a CBD -derived drug for seizures associated with Lennox-Gastaut Syndrome and Dravet Syndrome (28) .

If you plan on buying CBD products , you must research product specifications, testimonials, reviews, and third-party laboratory tests. According to the FDA , high doses of CBD may lead to liver injury (29) .

Meanwhile, in a recent study, medical researchers observed that CBD use may affect liver wellness and result in dose-related liver damage (30) .

The study also noted that the use of CBD may increase the risk of liver damage when use d with other drugs , such as leflunomide (analgesic), mipomersen (medication for high cholesterol), pexidartinib (giant cell tumor drug), teriflunomide (multiple sclerosis medication), and valproate ( epilepsy medication) (31) .

If you have severe or moderate liver damage , your doctor may advise slow dose titration, which pertains to the slow adjustment of a medication dose for the maximum benefit without adverse effects (32) .

According to Mayo Clinic, there have been no proven alternative medicine therapies for liver disease . Although some studies have indicated possible benefits, further research is still needed (33) .

  • Mistletoe
  • Skullcap, a plant from the mint family
  • Chaparral, a desert shrub
  • Comfrey, a plant used to treat inflammation and chronic pain (35)
  • Kava, a perennial herb
  • Pennyroyal oil, an oil sourced from a plant in the mint genus
  • Vitamin A
  • Ma-huang, a Chinese herb
  • Germander, a plant from the mint family
  • Valerian, a flowering perennial plant

The list above highlights the importance of seeking medical advice before trying alternative medicine, such as CBD . Consult your doctor on the potential risks of these treatments before you opt for complementary or alternative therapies.

You should also conduct thorough research about CBD . To learn more about CBD ‘s potential risks, visit the National Institutes of Health ( NIH ) website https://www. nih . gov / .

CBD Dosage and Consumption Methods

Dosage

There are various factors to consider to ensure safe CBD dosing . These factors include the product’s CBD potency, CBD concentration, the user’s body weight , and the desired results.

According to a comprehensive review cited in a study from Cannabis and Cannabinoid Research, humans may tolerate a CBD dosage of up to 1,500mg per day (36) .

Administration Methods

  • Sublingual (dropping CBD oil under the tongue) method
  • Ingesting CBD tablets, capsules, or other edibles
  • Mixing CBD into food or drinks
  • Applying CBD topicals or balms directly onto the skin

One of the most common methods to take CBD is through vaping. Inhaling CBD serves as a quick way to ingest CBD since the cannabinoid enters the body through the lungs’ bloodstream without going through the digestive system.

In a 2018 study, medical researchers noted that after vaping CBD , the user may experience the cannabinoid ’s highest plasma concentrations three minutes after the dose ( 37) .

However, some studies also noted that vaping may have detrimental effects on the lungs. According to a recent study, the increased vape use in the US resulted in the rise of vaping-related pulmonary problems (38) .

Aside from pulmonary health risks, other vaping hazards include allergic reactions or irritation to the chemicals in the inhaled vapors (39) .

Meanwhile, in a 2002 study, researchers noted that sublingual administration of CBD was an efficient way of taking the cannabinoid . According to the study, CBD oil had a sublingual bioavailability of 13% to 19% (40) .

Bioavailability pertains to the extent and rate at which a medication is absorbed and becomes readily available for the body to process and break down (41) .

According to a 2015 review, researchers observed that with the sublingual route of consumption, most compounds’ peak blood levels may be reached in 10 to 15 minutes. The researchers noted that this was faster than when the same drugs are ingested through oral administration.

If you do not like the taste of hemp oil , some CBD brands provide CBD edibles, like CBD gummies, in delicious flavors. Some companies also offer unflavored options in their CBD oil product line to encourage more individuals to buy.

You may also opt to mix CBD oils into your favorite meals. According to a 2018 study, cannabinoid ’s highly lipophilic nature (lipid or oil solubility) allows the compound to dissolve in the fat content of food, which may boost the compound’s absorption and solubility (42) .

You may also apply CBD directly to your skin. CBD may be infused in transdermal products, including cream, lotion, balm, or salve.

One of the major advantages of the transdermal application of CBD is that it avoids the first-pass metabolism, which causes more constant plasma levels (43) . The first-pass effect pertains to the early metabolization of a drug, reducing drug concentration s before the s ubstance reaches its intended site of action (44) .

In a 2018 study, medical researchers noted that CBD ’s half-life is 24 hours after an intravenous administration and 31 hours after pulmonary administration (45) . Half-life is the time required for one-half of a drug’s concentration to decrease to half of its initial dose in the body (46) .

Meanwhile, researchers noted that the half-life of CBD is between 1.4 hours and 10.9 hours after an oromucosal (surface of the mouth) consumption route. The authors of the research recorded that the half-life of CBD is two to five days after an oral administration (47) .

Choosing the Right CBD Oil for Liver Disease

Regardless of the kind of CBD products you want, you must employ careful consideration when hunting for the highest-quality CBD oil for liver problems.

  • Seek medical advice before using CBD . Learn about possible drug-to-drug interactions and adverse effects of CBD use for liver disease .
  • Look for brands certified by the US Hemp Authority or other accrediting organizations.
  • Compare the information on the product label to the data from the third-party lab reports.
  • Research the state CBD laws applicable in your area.
  • Read the reviews of past buyers before purchasing a CBD product .

Legality of CBD

The then President Donald Trump legalized hemp production at the federal level in 2018 when he signed the Farm Bill into law. The Farm Bill removed hemp and hemp-derived products with less than 0.3% of tetrahydrocannabinol ( THC ) from the list of Schedule I controlled substances (48) .

Although the Farm Bill did not legalize marijuana and marijuana-derived products, state lawmakers can implement their own laws regarding medical and recreational marijuana legalization.

Although CBD is federally legal, you must first research state CBD laws before purchasing CBD products . As of December 2020, the FDA still has not regulated the production and the marketing of CBD (49) .

You should also note that state laws have varying levels of restrictions regarding CBD regulations. In some places , like South Dakota, state laws about CBD remain unclear (50) .

Product Frequently
Asked Questions

In a 2008 study, the authors suggested that CBD may work as a cannabinoid receptor agonist and antagonist (51) . Another study demonstrated that a CB2 receptor agonist may improve fibrogenesis and accelerated liver regeneration (52) .

The researchers of a study published in the British Journal of Pharmacology observed that CBD improved acute liver failure symptoms on animal subjects (53) . Another study published in Pharmacognosy Research noted that CBD may help treat HCV (54) .

According to a recent StatPearls article, CBD may cause dose-related liver damage (55) . StatPearls is a database of short review articles for health professionals in nursing, medicine, and allied health.

In a study published in the Medical Cannabis Cannabinoids journal, researchers stated that cannabinoids may affect liver activity, specifically the cytochrome P450 (CYP450) enzymes’ metabolic processes. The activation of these liver enzymes may have significant effects on other medications (56) .

Since the liver metabolizes several medications in the body, you must practice caution when taking CBD with other drugs. Instead of using CBD with other liver disease medications, you may choose to live a healthier lifestyle, which involves less alcohol intake, a more nutritious diet, and exercise.

Although ingesting trace amounts of THC may not result in a positive drug test, frequent use of CBD products may increase THC level s in the body. Drug tests can detect high concentrations of THC in the body (57) .

According to a Cannabis and Cannabinoid Research study, humans can tolerate CBD doses of up to 1 , 500mg per day (58) .

An excellent CBD product is made up of organic ingredients and hemp-derived CBD . CBD users must also look for products free from contaminants, including herbicides, additives, pesticides , residual solvents, heavy metals, and other harmful substances.

Most CBD brands have online shops where you may purchase CBD products. Customers need to provide their payment information only at the checkout page and wait for their purchase to arrive at their door.