benefits of cbd oil for bipolar disorder dosage

CBD for Bipolar Disorder: Does Cannabidiol Benefit Bipolar Disorder?

CBD for Bipolar Disorder: Medical Cannabidiol Health Research + Treatment Guide

Bipolar disorder, sometimes known as manic depression, is a mental health condition in which diagnosed individuals experience periods of elevated or depressive moods. Individuals diagnosed with bipolar disorder commonly suffer from impulsive actions and abnormal mood swings, and are typically treated with a range of powerful antipsychotic medications.

Recent research into the health benefits of CBD, however, reveals that cannabidiol extracted from the hemp plant could potentially replace the powerful side effect inducing medications used to treat bipolar disorder and provide individuals diagnosed with the condition with a completely natural alternative.

The causes of bipolar disorder are poorly understood, but are largely influenced by genetics. The condition is generally classified as bipolar I disorder in the case of a single manic episode, and bipolar II disorder if the diagnosed individual has experienced both a manic and a depressive episode.

Treating bipolar disorder can be difficult. Some treatment methods include psychotherapy, but a large portion of the treatment methodology currently used to target bipolar disorder involves the use of mood stabilizers, antidepressants, and antipsychotics.

These powerful drugs, such as olanzapine, quetiapine, and clozapine can help to minimize the impact of bipolar disorder, but are known to cause a wide range of unwanted side effects. These side effects can include stiffness, shakiness, weight gain, sleepiness, constipation, sexual problems, hormone changes, and even suicidal thoughts.

CBD for bipolar disorder has been proven to function as a surprisingly effective alternative to these medications, and has been demonstrated in a wide range of different clinical investigations to provide relief from the symptoms of the condition without causing any unwanted side effects or health issues.

In this article, we’ll take a close look at the different ways in which CBD can help individuals diagnosed with bipolar disorder to improve their health. We’ll assess the interactions between cannabidiol and the brain in order to understand the science that drives CBD for bipolar research and examine the clinical trials that have revealed it to be a powerful therapeutic bipolar disorder treatment.

What is CBD?

CBD, also known as cannabidiol, is a cannabinoid compound that is found in the hemp, or cannabis sativa plant. There are many different active natural compounds in the hemp plant, including THC, which is the psychoactive compound associated with recreational marijuana use.

Cannabidiol, however, is a remarkable cannabinoid compound that possesses properties that make it very dissimilar to THC. Cannabidiol is not psychoactive. CBD is extracted from the cannabis plant via a wide range of different extraction methods, and can be found in virtually every single part of the hemp plant.

Research into the health benefits of cannabidiol has been underway since the early 1990’s, but a new wave of renewed scientific research catalyzed by a loosening of medical marijuana laws in the United States has revealed a broad spectrum of health benefits that this unique natural compound can provide.

CBD has been demonstrated to deliver a wide range of benefits that include decreased inflammation, increased immune system function, protection from a number of different cancers, and has even been demonstrated to function as a powerful antibiotic, or prevent the onset of seizures in individuals diagnosed with epilepsy.

The neurochemical impact of cannabidiol, however, is what makes it highly interesting to individuals diagnosed with bipolar disorder. One of the biggest advantages cannabidiol offer bipolar-affected individuals is that it is non-habit forming, causes no side effects, and, most importantly, can be purchased without a prescription in most states of the US.

CBD is legal in most states primarily because it does not contain any THC. There are a number of states that do make it possible for suppliers to sell products that contain a combination of THC and CBD, known as tinctures, but these solutions do not offer any specific advantages to individuals diagnosed with bipolar disorder over pure CBD products.

Another major feature of CBD for bipolar is the ease of use it offers. CBD can be administered as a simple CBD sublingual drop beneath the tongue, but is also available in edible and topical form. Individuals interested in the health benefits of CBD are able to select from a wide range of CBD gummies, CBD soaps CBD vape pens, CBD bath bombs, and even CBD cooking oil, all of which have been proven to minimize the impact of bipolar disorder.

CBD has been demonstrated to be able to assist with a wide range of mental health conditions, including PTSD, schizophrenia, depression, anxiety, and bipolar, but is also even able to help with neurodegenerative conditions such as dementia, Parkinson’s, and Alzheimer’s.

How Does CBD Work?

Every living vertebrate organism on the planet possesses an endocannabinoid system — including humans. This endocannabinoid system is responsible for a wide range of functions, and is able to interact with the immune system, the gastrointestinal system, the endocrine system and, importantly, the brain.

The human body produces “endocannabinoids,” which are cannabinoids created within the human body. Because of this, there are specific receptors in the human body to which these endocannabinoids bind as part of normal bodily function.

Exogenous cannabinoids, or cannabinoids from outside the human body — such as cannabidiol — are able to interact with these same endocannabinoid receptors, with interesting results. Phytocannabinoids extracted from the hemp plant have been observed, for example, to interact with the cannabinoid receptors in the digestive system of the human body and dramatically lower inflammation, making CBD an ideal treatment for individuals suffering from inflammatory disorders such as irritable bowel syndrome.

The ability of CBD to pass through the blood/brain barrier, however, is what makes it so important to individuals diagnosed with bipolar disorder.

When cannabidiol reaches the human brain, and interesting interaction occurs. The human brain produces a hormone called serotonin, which is intrinsically linked to a wide range of mental functions and mood states.

Individuals diagnosed with bipolar disorder are commonly prescribed with SSRIs, or selective serotonin reuptake inhibitors, which interact with the way the brain uses serotonin. These pharmaceutical chemicals prevent the reabsorption of serotonin in the brain to prolong its usefulness, which has a positive impact on mood balance.

The exact mechanism through which serotonin balances mood and emotion is poorly understood by modern science, but clinical evidence shows that extending the functional lifespan of serotonin in the brain is able to minimize the impact of bipolar disorders. SSRIs achieve this by interacting with receptors in the brain in order to prevent serotonin reuptake.

Cannabidiol works in a similar manner. There are a number of cannabinoid receptors in the human brain that, when modulated by cannabidiol, can attenuate serotonin production and release, delivering a profound positive effect on the cognitive state of individuals diagnosed with bipolar disorder.

The advantages CBD offers over traditional antipsychotics and SSRIs are compelling — CBD is able to promote mood stability and assist individuals diagnosed with bipolar disorder in living a fulfilling life with a stable mental state without causing any deleterious side effects or inducing dependency on any drugs.

To many individuals that have shifted from SSRIs and antipsychotics to CBD for bipolar disorder management, cannabinoid is a highly effective solution that has completely changed the way they interact in daily life.

Can CBD Help With Bipolar Disorder?

The endocannabinoid system is extremely important to the function of the human brain in general. Endocannabinoids are used by the body to regulate a wide range of cognitive and bodily functions, include stress responses and anxiety, moods and emotional responses, sleep cycles, memory retention and learning, metabolic functions, and many more.

When exogenous cannabinoids such as cannabidiol enter the human body, they mimic the function of these endogenous cannabinoids. Importantly, exogenous cannabinoids are far stronger and longer lasting than the endogenous cannabinoid so the human body, and can even help to make endogenous cannabinoids more effective.

There are a range of health benefits provided by CBD to individuals with bipolar disorder

  • Elevated mood
  • Balanced mood
  • Enhanced mood control
  • Emotional stability
  • Decreased stress
  • Elimination of bipolar disorder drug side effects
  • Improved energy levels
  • Minimized oxidative stress and inflammation in the brain
  • Improved cognitive ability and memory
  • Improved verbal fluency

CBD helps to minimize the impact of bipolar disorders in three different ways.

Firstly, cannabidiol is able to function as a potent antipsychotic, antidepressant, and anti-anxiety solution. CBD achieves this by modulating specific receptors in the human brain that are responsible for the distribution of the serotonin hormone.

By increasing serotonin levels, CBD is able to deliver mood balance and prevent bipolar episodes. The science behind the way CBD and bipolar disorder works is a little more complex, but the basic way in which it works is primarily concerned with serotonin.

Secondly, CBD is a powerful neuroprotective agent. The human brain can be affected by inflammation in the human body through a process called neuroinflammation. This process is partially responsible for mood disorders and, if left unchecked, can progress into serious neurodegenerative disorders such as Alzheimer’s, Huntington’s, or Parkinson’s,

Lastly, cannabidiol is able to promote growth in the hippocampus region of the human brain. The hippocampus is closely linked to a wide range of cognitive functions and is associated with mood balance, emotional control, and memory recall.

Clinical investigations have demonstrated that individuals that have been diagnosed with mental health disorders such as depression, anxiety, bipolar, and schizophrenia all possess smaller hippocampi than normal.

CBD has been proven to promote neurogenesis, or the growth of new neuron cells, in these regions.

The Science Behind CBD and Bipolar Disorder

Current clinical science investigating the impact of CBD on the brain reveals that cannabinoids are able to activate a number of receptors that are responsible for serotonin. At medium-level doses, cannabinoids such as cannabidiol are able to activate the 5-HT1A hydroxytryptamine serotonin receptor.

The 5-HT1A receptor is part of a family of receptors that are activated by serotonin. This critical neurotransmitter receptor is found in the brain and both the central and peripheral nervous systems. When CBD passes through the blood/brain barrier, it activates these receptors, catalyzing a cascade of chemical messages between the cells of the human body.

Cannabidiol binds to these receptors but also shows an affinity for other receptors, including the receptors that make up the endocannabinoid system. Overall, CBD functions as a CBD agonist, and is able to modulate the parts of the brain that are responsible for anxiety, sleep, pain, mood, emotional, and addition.

One of the most unique applications of CBD, however, is also what makes it so effective in assisting with the management of bipolar disorders. In addition to modulating the 5-HT1A receptor, CBD is also able to interact with the 5H3TA receptor.

This receptor is closely linked to the nausea response in the brain, making CBD a highly effective anti-nausea solution. For this reason, CBD is often used to treat motion sickness and even assist individuals that are suffering from nausea as a side effect of cancer treatments such as chemotherapy.

Regulating the nausea response in the body is not the only job of the 5H3TA receptor, however. The 5H3TA receptor is also responsible to a large degree for regulating mood response. Clinical research indicates that cannabidiol compounds are negative allosteric modulators of the 5H3TA receptor.

While this may sound complex, it means that CBD makes the receptor less likely to bind with serotonin. This property means that CBD functions in a very similar manner to traditional antipsychotic medications and SSRIs without causing any of the side effects, dependency, and unwanted health consequences they are associated with.

Clinical Evidence

The use of CBD for bipolar is backed up by an extremely large body of clinical evidence, which includes extensive in vitro and in vivo, with several notable human trials that delivered impressive results.

A clinical investigation published in the British Journal of Pharmacology in 2008 examined the way in which cannabinoids interact with the 5-HT1A receptors. This trial used an animal model in which male rodents were injected with an injection of CBD in varying doses ranging from 1 to 20mg per kg, with all subjects subsequently subjected to a restraint test that observed their cardiovascular responses.

The results discovered by the clinical investigation revealed that CBD is able to delay high-level emotional responses by modulating the 5-HT1A receptors.

The evidence gathered in this clinical trials supports previous evidence published in an earlier clinical investigation into the efficacy with which CBD can be used to treat bipolar disorder. Published in 1998, the study reveals that cannabinoids can be used as an alternative to lithium, a commonly prescribed antipsychotic medication.

The most widely-cited clinical investigation into the potential benefits of cannabidiol in treating bipolar disorder was published in 2005, identifying cannabidiol as a potential alternative therapy for individuals diagnosed with the condition due to the wide range of sedative, antidepressant, and anxiolytic benefits the compound offers.

Another clinical trial published more recently in 2019 provides concrete evidence that CBD is able to modulate the serotonin pathways of the human brain. In the trial, participants were administered with varying doses of CBD ranging from 0.1 to 10 mg per kg, revealing that CBD is conclusively able to minimize anxiety by activating the 5-HT1A receptor.

CBD Dosage for Bipolar Disorder

The best dosage of CBD for various health conditions can vary greatly depending on a wide range of different factors that include the weight of an individual, their individual metabolic rate, and the benefits they aim to achieve.

Before beginning any CBD dosing routing, it’s essential to first consult with a qualified medical practitioner or doctor. A doctor will be able to tell you whether or not taking up a course of CBD dosing is the best action for your health condition and will advise of any potential interactions between CBD and existing pharmaceutical drug regimes.

To date, there are not any conclusive clinical trials assessing the effectiveness of specific doses of CBD in treating bipolar disorder. Many clinical trials for other mental health conditions have been performed, however, and typically use very high doses of up to 600mg.

It should be noted, however, that many individuals using CBD for various health conditions don’t use such high doses. CBD use for anxiety, for example, is commonly dosed at as little at 5mg per day.

A 25mg per day starting point spread over several sublingual drops is a common starting point for many individuals seeking to determine whether CBD is the right choice for them in managing their bipolar disorder.

When beginning a CBD dosing routine, it’s best to begin with a regular low dose and keep a journal of the health impact of the dose. Increasing the dose incrementally until health benefits are achieved allows individuals to determine the best dosage for them.

As a whole, dosing is extremely subjective, and can depend on the efficacy and strength of the CBD product used, the delivery method, and the health benefit the user is trying to achieve.

Best CBD Products for Bipolar Disorder

As bipolar disorder is a mental health condition, there are many different administration methods that can be used. The mental health benefits of CBD can be achieved by sublingual dosage, via edibles, or transdermal patches.

As a general rule, topical CBD solutions and other CBD products that are applied to the skin are less effective in treating mental health with CBD, as the cannabidiol must travel further to pass through the blood/brain barrier.

Sublingual application of CBD oil for bipolar disorder is arguably the most effective method, as it bypasses the digestive system entirely and allows CBD to enter the bloodstream directly to the brain, where it delivers the best health benefits.

Best CBD Products for Bipolar Disorder

  • CBD oil
  • CBD drops
  • CBD paste
  • CBD gum
  • CBD gummies
  • CBD edibles

CBD Safety

CBD is one of the safest natural health substances available on the market today. Clinical research indicates that there is no upper toxicity limit to CBD dosage, with an extremely high dose of 1500mg demonstrated to be well-tolerated in multiple investigations.

It’s extremely important that you consult with a medical professional or a doctor before beginning a CBD dosing routine. There are a number of mild side effects associated with the use of CBD, which include the following:

  • Mild sedation
  • Sleepiness
  • Dry mouth
  • Reduction of T and B cells
  • Reduced activity of cytochrome cells
  • Decreased fertilization capability
  • Mild low blood pressure

Current clinical science proves that CBD, overall, is generally harmless. There are, however, a number of medications that CBD is known to interfere with. These drugs all rely on the CYP450 enzyme, which is made in the liver. This enzyme is important to the metabolism of the following drugs:

If you are taking any of the above drugs it is essential to consult with a doctor before taking CBD products.

Q: What is CBD?

A: CBD is a naturally occurring plant compound that is extracted from the hemp, or cannabis plant. Unlike THC, CBD is not psychoactive. CBD interacts with the existing endocannabinoid system found within the human body to modulate a wide range of biological functions, thereby providing a broad spectrum of different health benefits.

Q: Is CBD legal?

A: CBD is not psychoactive and has been approved for sale under strict guidelines in 50 US states as well as a number of international countries. CBD products generally contain less than 0.3% THC, which makes them non-psychoactive and legal for purchase and use.

Q: Is CBD better than other bipolar disorder medications?

A: CBD has been demonstrated to function as an effective antipsychotic and anti-anxiety therapeutic treatment and is used as a replacement for traditional psychiatric medications by hundreds of thousands of people around the world.

Q: Is CBD able to cure bipolar syndrome?

A: Bipolar disorder is a complex mental health condition that requires careful management. The use of CBD for bipolar syndrome, however, is an extremely promising alternative therapy.

Q: Is CBD safe?

A: CBD is one of the safest natural compounds available and does not cause any unwanted or dangerous side effects.

CBD (Cannabidiol)

In addition to the items below, for more information on CBD you should check out Project CBD.

Page last updated by Dec. 16, 2020 by Doug McVay, Editor.

“Since several years, other pharmacologically relevant constituents of the Cannabis plant, apart from Δ9-THC, have come into the focus of research and legislation. The most prominent of those is cannabidiol (CBD). In contrast to Δ9-THC, it is nonintoxicating, but exerts a number of beneficial pharmacological effects. For instance, it is anxiolytic, anti-inflammatory, antiemetic, and antipsychotic. Moreover, neuroprotective properties have been shown.1,2 Consequently, it could be used at high doses for the treatment of a variety of conditions ranging in psychiatric disorders such as schizophrenia and dementia, as well as diabetes and nausea.1,2

“At lower doses, it has physiological effects that promote and maintain health, including antioxidative, anti-inflammatory, and neuroprotection effects. For instance, CBD is more effective than vitamin C and E as a neuroprotective antioxidant and can ameliorate skin conditions such as acne.3,4

“The comprehensive review of 132 original studies by Bergamaschi et al. describes the safety profile of CBD, mentioning several properties: catalepsy is not induced and physiological parameters are not altered (heart rate, blood pressure, and body temperature). Moreover, psychological and psychomotor functions are not adversely affected. The same holds true for gastrointestinal transit, food intake, and absence of toxicity for nontransformed cells. Chronic use and high doses of up to 1500 mg per day have been repeatedly shown to be well tolerated by humans.1

“Nonetheless, some side effects have been reported for CBD, but mainly in vitro or in animal studies. They include alterations of cell viability, reduced fertilization capacity, and inhibition of hepatic drug metabolism and drug transporters (e.g., p-glycoprotein).1 Consequently, more human studies have to be conducted to see if these effects also occur in humans. In these studies, a large enough number of subjects have to be enrolled to analyze long-term safety aspects and CBD possible interactions with other substances.”

Iffland, Kerstin, and Franjo Grotenhermen. “An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies.” Cannabis and cannabinoid research vol. 2,1 139-154. 1 Jun. 2017, doi:10.1089/can.2016.0034
https://www.ncbi.nlm.nih.gov/p.

“Cannabidiol (CBD) oil is essentially a concentrated solvent extract made from cannabis flowers or leaves that is dissolved in an edible oil such as sunflower, hemp, or olive oil. Solvents used can vary from relatively innocuous organic solvents (ethanol, isopropyl alcohol) to more harmful ones (petroleum-ether, naphtha), or even supercritical fluids (butane, CO2). The exact conditions and solvents applied have a great impact on, for example, the taste, color, and viscosity of the final product. Because many other plant components are co-extracted with the desired cannabinoids present in the herbal material, these are sometimes removed by a treatment known as “winterization.” By placing the extract in a freezer (–20 to –80°C) for 24–48 h, components with a higher melting point such as waxes and triglycerides, as well as chlorophyll will precipitate, so they can be removed by filtration or centrifugation [1]. This treatment can significantly improve the taste and color of the final product.

“Cannabis oils may contain various concentrations of CBD, tetrahydrocannabinol (THC), and minor cannabinoids, mainly depending on the cannabis variety used for extraction. The most popular product currently is CBD oil, but for example cannabigerol (CBG)-rich oil has been spotted as well [2], and others will very likely follow soon. The THC-rich type of cannabis oil has already been known for some years, and is generally known under the name “Simpson oil” [3]. Terpenes may or may not be present in these products, depending on the preparation method used [4]. Because they are highly volatile, elevated temperatures (such as those applied during drying of plant materials, or during the evaporation of solvents) may result in a significant loss of terpene components [5]. However, it is possible to capture evaporated terpenes by condensation, and reintroduce them back into the final oil. Additional ingredients may be added to further adjust properties such as color, viscosity, taste, or shelf-life stability.”

Hazekamp A: The Trouble with CBD Oil. Med Cannabis Cannabinoids 2018;1:65-72. doi: 10.1159/000489287
https://www.karger.com/Article.

“Recent developments suggest that non-psychotropic phytocannabinoids exert a wide range of pharmacological effects (Figure 1), many of which are of potential therapeutic interest. The most studied among these compounds is CBD, the pharmacological effects of which might be explained, at least in part, by a combination of mechanisms of action (Table 1, Figure 1). CBD has an extremely safe profile in humans, and it has been clinically evaluated (albeit in a preliminary fashion) for the treatment of anxiety, psychosis, and movement disorders. There is good pre-clinical evidence to warrant clinical studies into its use for the treatment of diabetes, ischemia and cancer. The design of further clinical trials should: i) consider the bell-shaped pattern of the dose–response curve that has been observed in pre-clinical pharmacology, and ii) establish if CBD is more effective or has fewer unwanted effects than other medicines. A sublingual spray that is a standardized Cannabis extract containing approximately equal quantities of CBD and D9-THC (Sativex ® ), has been shown to be effective in treating neuropathic pain in multiple sclerosis patients [76].
“The pharmacology of D9-THCV (i.e. CB1 antagonism associated with CB2 agonist effects) is also intriguing because it has the potential of application in diseases such as chronic liver disease or obesity—when it is associated with inflammation—in which CB1 blockade together with some CB2 activation is beneficial.
“The plant Cannabis is a source of several other neglected phytocannabinoids such as CBC and CBG. Although the spectrum of pharmacological effects of these compounds is largely unexplored, their potent action at TRPA1 and TRPM8 might make these compounds new and attractive tools for pain management.”

Izzo, Angelo A.; Borrelli, Francesca; Capasso, Raffaele; Di Marzo, Vincenzo; and Mechoulam, Raphael, “Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb,” Trends in Pharmacological Sciences (London, United Kingdom: October 2009) Vol. 30, Issue 10, pp. 525-526.
http://www.ncbi.nlm.nih.gov/pu.
http://cannabisinternational.o.

“We synthesised available evidence on the safety and efficacy of cannabinoids as an adjunctive treatment to conventional AEDs [Antiepileptic Drugs] in treating drug-resistant epilepsy. In many cases, there was qualitative evidence that cannabinoids reduced seizure frequency in some patients, improved other aspects of the patients’ quality of life and were generally well tolerated with mild-to-moderate AEs [Adverse Events]. We can be much more confident about this statement in the case of children than adults, because the recent, larger, well-conducted RCTs [Randomized Controlled Trials] were performed in children and adolescents.

“In studies where there was greater experimental control over the type and dosage of cannabinoid used, there was evidence that adjuvant use of CBD reduced the frequency of seizures, particularly in treatment-resistant children and adolescents, and that patients were more likely to achieve complete seizure freedom. There was a suggestion that the benefits of adding CBD may be greater when patients were also using clobazam. 11 12 However because clobazam and CBD are both metabolised in the cytochrome P450 pathway, the pharmacokinetic interactions of these two drugs still need to be fully determined 56 Further randomised, double-blind studies with a placebo or active control are needed to strengthen this conclusion.

“Non-RCT evidence was consistent with RCT evidence that suggested cannabinoids may reduce the frequency of seizures. In most of these studies, cannabinoid products and dosages were less well-controlled, and outcomes were based on self-report (often by parents). These studies provide lower quality evidence compared with RCTs due to the potential for selection bias in the study populations, and other weaknesses in study design. There was also some evidence that studies at very high risk of bias had higher reported proportions of participants reporting reductions in seizures and lower proportions reporting AEs. In RCTs, and most of the non-RCTs, cannabinoids were used as an adjunctive therapy rather than as a standalone intervention, so at present there is little evidence to support any recommendation that cannabinoids can be recommended as a replacement for current standard AEDs.”

Stockings, Emily & Zagic, Dino & Campbell, Gabrielle & Weier, Megan & Hall, Wayne & Nielsen, Suzanne & K Herkes, Geoffrey & Farrell, Michael & Degenhardt, Louisa. (2018). Evidence for cannabis and cannabinoids for epilepsy: a systematic review of controlled and observational evidence. Journal of Neurology, Neurosurgery & Psychiatry. jnnp-2017. 10.1136/jnnp-2017-317168.
https://www.ncbi.nlm.nih.gov/p.
http://jnnp.bmj.com/content/ea.

“Some studies indicate that under certain circumstances, CBD acute anxiolytic effects in rats were reversed after repeated 14-day administration of CBD.2 However, this finding might depend on the used animal model of anxiety or depression. This is supported by a study, where CBD was administered in an acute and “chronic” (2 weeks) regimen, which measured anxiolytic/antidepressant effects, using behavioral and operative models (OBX=olfactory bulbectomy as model for depression).18 The only observed side effects were reduced sucrose preference, reduced food consumption and body weight in the nonoperated animals treated with CBD (50 mg/kg). Nonetheless, the behavioral tests (for OBX-induced hyperactivity and anhedonia related to depression and open field test for anxiety) in the CBD-treated OBX animals showed an improved emotional response. Using microdialysis, the researchers could also show elevated 5-HT and glutamate levels in the prefrontal cortex of OBX animals only. This area was previously described to be involved in maladaptive behavioral regulation in depressed patients and is a feature of the OBX animal model of depression. The fact that serotonin levels were only elevated in the OBX mice is similar to CBD differential action under physiological and pathological conditions.

“A similar effect was previously described in anxiety experiments, where CBD proved to be only anxiolytic in subjects where stress had been induced before CBD administration. Elevated glutamate levels have been proposed to be responsible for ketamine’s fast antidepressant function and its dysregulation has been described in OBX mice and depressed patients. Chronic CBD treatment did not elicit behavioral changes in the nonoperated mice. In contrast, CBD was able to alleviate the affected functionality of 5HT1A receptors in limbic brain areas of OBX mice.18 and references therein

“Schiavon et al. cite three studies that used chronic CBD administration to demonstrate its anxiolytic effects in chronically stressed rats, which were mostly mediated via hippocampal neurogenesis.19 and references therein For instance, animals received daily i.p. injections of 5 mg/kg CBD. Applying a 5HT1A receptor antagonist in the DPAG (dorsal periaqueductal gray area), it was implied that CBD exerts its antipanic effects via these serotonin receptors. No adverse effects were reported in this study.”

Iffland, Kerstin, and Franjo Grotenhermen. “An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies.” Cannabis and cannabinoid research vol. 2,1 139-154. 1 Jun. 2017, doi:10.1089/can.2016.0034
https://www.ncbi.nlm.nih.gov/p.

“Various studies on CBD and psychosis have been conducted. 20 For instance, an animal model of psychosis can be created in mice by using the NMDAR antagonist MK-801. The behavioral changes (tested with the prepulse inhibition [PPI] test) were concomitant with decreased mRNA expression of the NMDAR GluN1 subunit gene (GRN1) in the hippocampus, decreased parvalbumin expression (=a calcium-binding protein expressed in a subclass of GABAergic interneurons), and higher FosB/ΔFosB expression (=markers for neuronal activity). After 6 days of MK-801 treatment, various CBD doses were injected intraperitoneally (15, 30, 60 mg/kg) for 22 days. The two higher CBD doses had beneficial effects comparable to the atypical antipsychotic drug clozapine and also attenuated the MK-801 effects on the three markers mentioned above. The publication did not record any side effects. 21

“One of the theories trying to explain the etiology of bipolar disorder (BD) is that oxidative stress is crucial in its development. Valvassori et al. therefore used an animal model of amphetamine-induced hyperactivity to model one of the symptoms of mania. Rats were treated for 14 days with various CBD concentrations (15, 30, 60 mg/kg daily i.p.). Whereas CBD did not have an effect on locomotion, it did increase brain-derived neurotrophic factor (BDNF) levels and could protect against amphetamine-induced oxidative damage in proteins of the hippocampus and striatum. No adverse effects were recorded in this study. 22

“Another model for BD and schizophrenia is PPI of the startle reflex both in humans and animals, which is disrupted in these diseases. Peres et al., list five animal studies, where mostly 30 mg/kg CBD was administered and had a positive effect on PPI.20 Nonetheless, some inconsistencies in explaining CBD effects on PPI as model for BD exist. For example, CBD sometimes did not alter MK-801-induced PPI disruption, but disrupted PPI on its own. 20 If this effect can be observed in future experiments, it could be considered to be a possible side effect.”

Iffland, Kerstin, and Franjo Grotenhermen. “An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies.” Cannabis and cannabinoid research vol. 2,1 139-154. 1 Jun. 2017, doi:10.1089/can.2016.0034
https://www.ncbi.nlm.nih.gov/p.

“Today, CBD is used for the treatment of a wide range of medical conditions. This started with the somewhat serendipitous discovery (by parents experimenting with self-medication for their children) that CBD had a therapeutic effect on a serious form of epilepsy in children, called Dravet syndrome [8]. This effect is now under clinical investigation with the pharmaceutical CBD product Epidiolex®, which is currently in phase 3 trials with encouraging results [9, 10]. The media attention generated by its effect on severely ill children gave CBD the push needed to become a much desired medicine almost overnight [11]. Other medical indications that may be treated with CBD, and are supported to some extent by clinical proof, include Parkinson’s disease [12], schizophrenia [13], and anxiety disorder [14]. However, although research into the therapeutic effects of CBD is rapidly increasing, most current uses of CBD are not (yet) supported by clinical data. The popular use of these products means that physicians may be confronted with the effects of CBD oil even when they do not prescribe it themselves.

“An excellent example is the use of CBD (and also THC) products for the self-medicating of cancer, with the intention of fully curing it [15]. This is based on an increasing body of preclinical evidence showing cannabinoids to be capable, under some conditions, of inhibiting the development of cancer cells in vitro or in vivo by various mechanisms of action, including induction of apoptosis, inhibition of angiogenesis, and arresting the cell cycle [16]. This is certainly exciting news, and research is ongoing around the world, but there is no solid clinical evidence yet to support that cannabinoids – whether natural or synthetic – can effectively and safely treat cancer in actual humans [17]. In fact, there are indications that certain types of cancer may even accelerate when exposed to cannabinoids [18]. This becomes problematic when patients choose to refuse chemotherapy treatment because they firmly believe in the rumored curative properties of cannabinoids. As a result, recommendation of cannabinoids for treating cancer should be done with great care, and with distinction as to the type of cancer being treated [19].”

Hazekamp A: The Trouble with CBD Oil. Med Cannabis Cannabinoids 2018;1:65-72. doi: 10.1159/000489287
https://www.karger.com/Article.

“CBD, which is nonhedonic, can reduce heroin-seeking behavior after, for example, cue-induced reinstatement. This was shown in an animal heroin self-administration study, where mice received 5 mg/kg CBD i.p. injections. The observed effect lasted for 2 weeks after CBD administration and could normalize the changes seen after stimulus cue-induced heroin seeking (expression of AMPA, GluR1, and CB1R). In addition, the described study was able to replicate previous findings showing no CBD side effects on locomotor behavior. 23 “

Iffland, Kerstin, and Franjo Grotenhermen. “An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies.” Cannabis and cannabinoid research vol. 2,1 139-154. 1 Jun. 2017, doi:10.1089/can.2016.0034
https://www.ncbi.nlm.nih.gov/p.

“There are various mechanisms underlying neuroprotection, for example, energy metabolism (whose alteration has been implied in several psychiatric disorders) and proper mitochondrial functioning. 24 An early study from 1976 found no side effects and no effect of 0.3–300 μg/mg protein CBD after 1 h of incubation on mitochondrial monoamine oxidase activity in porcine brains. 25 In hypoischemic newborn pigs, CBD elicited a neuroprotective effect, caused no side effects, and even led to beneficial effects on ventilatory, cardiac, and hemodynamic functions. 26

“A study comparing acute and chronic CBD administration in rats suggests an additional mechanism of CBD neuroprotection: Animals received i.p. CBD (15, 30, 60 mg/kg b.w.) or vehicle daily, for 14 days. Mitochondrial activity was measured in the striatum, hippocampus, and the prefrontal cortex. 27 Acute and chronic CBD injections led to increased mitochondrial activity (complexes I-V) and creatine kinase, whereas no side effects were documented. Chronic CBD treatment and the higher CBD doses tended to affect more brain regions. The authors hypothesized that CBD changed the intracellular Ca2+ flux to cause these effects. Since the mitochondrial complexes I and II have been implied in various neurodegenerative diseases and also altered ROS (reactive oxygen species) levels, which have also been shown to be altered by CBD, this might be an additional mechanism of CBD-mediated neuroprotection. 1,27

“Interestingly, it has recently been shown that the higher ROS levels observed after CBD treatment were concomitant with higher mRNA and protein levels of heat shock proteins (HSPs). In healthy cells, this can be interpreted as a way to protect against the higher ROS levels resulting from more mitochondrial activity. In addition, it was shown that HSP inhibitors increase the CBD anticancer effect in vitro. 28 This is in line with the studies described by Bergamaschi et al., which also imply ROS in CBD effect on (cancer) cell viability in addition to, for example, proapoptotic pathways such as via caspase-8/9 and inhibition of the procarcinogenic lipoxygenase pathway. 1

“Another publication studied the difference of acute and chronic administration of two doses of CBD in nonstressed mice on anxiety. Already an acute i.p. administration of 3 mg/kg was anxiolytic to a degree comparable to 20 mg/kg imipramine (an selective serotonin reuptake inhibitor [SSRI] commonly prescribed for anxiety and depression). Fifteen days of repeated i.p. administration of 3 mg/kg CBD also increased cell proliferation and neurogenesis (using three different markers) in the subventricular zone and the hippocampal dentate gyrus. Interestingly, the repeated administration of 30 mg/kg also led to anxiolytic effects. However, the higher dose caused a decrease in neurogenesis and cell proliferation, indicating dissociation of behavioral and proliferative effects of chronic CBD treatment. The study does not mention adverse effects. 19 “

Iffland, Kerstin, and Franjo Grotenhermen. “An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies.” Cannabis and cannabinoid research vol. 2,1 139-154. 1 Jun. 2017, doi:10.1089/can.2016.0034
https://www.ncbi.nlm.nih.gov/p.

“Numerous studies show the CBD immunomodulatory role in various diseases such as multiple sclerosis, arthritis, and diabetes. These animal and human ex vivo studies have been reviewed extensively elsewhere, but studies with pure CBD are still lacking. Often combinations of THC and CBD were used. It would be especially interesting to study when CBD is proinflammatory and under which circumstances it is anti-inflammatory and whether this leads to side effects (Burstein, 2015: Table 1 shows a summary of its anti-inflammatory actions; McAllister et al. give an extensive overview in Table 1 of the interplay between CBD anticancer effects and inflammation signaling). 29,30

“In case of Alzheimer’s disease (AD), studies in mice and rats showed reduced amyloid beta neuroinflammation (linked to reduced interleukin [IL]-6 and microglial activation) after CBD treatment. This led to amelioration of learning effects in a pharmacological model of AD. The chronic study we want to describe in more detail here used a transgenic mouse model of AD, where 2.5-month-old mice were treated with either placebo or daily oral CBD doses of 20 mg/kg for 8 months (mice are relatively old at this point). CBD was able to prevent the development of a social recognition deficit in the AD transgenic mice.

“Moreover, the elevated IL-1 beta and TNF alpha levels observed in the transgenic mice could be reduced to WT (wild-type) levels with CBD treatment. Using statistical analysis by analysis of variance, this was shown to be only a trend. This might have been caused by the high variation in the transgenic mouse group, though. Also, CBD increased cholesterol levels in WT mice but not in CBD-treated transgenic mice. This was probably due to already elevated cholesterol in the transgenic mice. The study observed no side effects. 31 and references within

“In nonobese diabetes-prone female mice (NOD), CBD was administered i.p. for 4 weeks (5 days a week) at a dose of 5 mg/kg per day. After CBD treatment was stopped, observation continued until the mice were 24 weeks old. CBD treatment lead to considerable reduction of diabetes development (32% developed glucosuria in the CBD group compared to 100% in untreated controls) and to more intact islet of Langerhans cells. CBD increased IL-10 levels, which is thought to act as an anti-inflammatory cytokine in this context. The IL-12 production of splenocytes was reduced in the CBD group and no side effects were recorded. 32

“After inducing arthritis in rats using Freund’s adjuvant, various CBD doses (0.6, 3.1, 6.2, or 62.3 mg/day) were applied daily in a gel for transdermal administration for 4 days. CBD reduced joint swelling, immune cell infiltration. thickening of the synovial membrane, and nociceptive sensitization/spontaneous pain in a dose-dependent manner, after four consecutive days of CBD treatment. Proinflammatory biomarkers were also reduced in a dose-dependent manner in the dorsal root ganglia (TNF alpha) and spinal cord (CGRP, OX42). No side effects were evident and exploratory behavior was not altered (in contrast to Δ9-THC, which caused hypolocomotion). 33 “

Iffland, Kerstin, and Franjo Grotenhermen. “An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies.” Cannabis and cannabinoid research vol. 2,1 139-154. 1 Jun. 2017, doi:10.1089/can.2016.0034
https://www.ncbi.nlm.nih.gov/p.

“Another chemical shared by both industrial hemp and marijuana is Cannabidiol (CBD). 48 CBD is unique because it is not intoxicating and it also moderates the euphoric effect of THC. 49 Marijuana, which has disproportionately higher levels of THC than industrial hemp, also contains lower levels of CBD. 50 The higher THC and lower CBD concentration gives marijuana its psychoactive effect. 51 Conversely, industrial hemp’s low THC levels and comparatively high CBD levels produce none of the intoxicating effects of marijuana. 52 “